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Summary Expression Gene Literature (66) GO Terms (8) Nucleotides (99) Proteins (21) Interactants (436) Wiki
XB-GENEPAGE- 480716

Gene Symbol: six1

Gene Name: SIX homeobox 1

Synonyms: XSix1
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor

Protein Function:
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Required f...[+]


Interactants: YYY

OMIM Disease Associations: BRANCHIOOTIC SYNDROME 3; BOS3 [+]
1/4
 
Xenbase Gene ID XB-GENE-480717 XB-GENE-480721 XB-GENE-17345620
Gene Symbol six1 six1.L six1.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.64641 [+] Xl.683
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 74 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine six1 six1.L six1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SIX1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Six1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN six1b six1a ZFIN Ensembl
chicken
GEISHA SIX1 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. [J Biol Chem 2000]
Most recent: Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes. [Dev Biol 2017]
View All Papers 15 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 8 terms 0 term
EC
PANTHER six1
KEGG Pathways K15614 K15614
KOG [K] Transcription factor SIX and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino six1 MO1 , six1 MO2 six1 MO1 , six1 MO2 six1 MO1 , six1 MO2
Affymetrix 1.0 Xl.683.1.S1_at
Affymetrix 2.0 Xl2.683.1.S1_at

Symbol legend[+]

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