Gene Symbol: six1 Gene Name: SIX homeobox 1 Synonyms: XSix1 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: sox2(13) , eya1(11) , foxd3(10) , pax3(10) , sox3(10) , msx1(9) , snai2(9) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001100223|Xenopus (Silurana) tropicalis SIX homeobox 1 (six1), mRNA GCCAGTACTTTCCCTGCGCTCAGAGCCGTGGATATAGCGTGTGCTCCCCGTGTATGCCTTTACGTGTGCGCTGTGGGCCCCTGGCTGTGCCACACTGAGCCATGTCTATGCTGCCTTCCTTTGGCTTCACTCAGGAGCAAGTGGCCTGTGTGTGCGAGGTGCTGCAGCAGGGAGGCAACCTGGAGAGACTGGGCAGGTTCCTATGGTCCTTGCCAGCCTGTGATCACCTCCACAAGAATGAGAGTGTGCTGAAGGCAAAGGCCGTGGTGGCATTTCACAGGGGCAACTTCAGAGAACTGTATAAGATACTGGAGAGCCATCAGTTCTCCCCGCACAACCACCCCAAACTGCAGCAACTCTGGCTCAAGGCTCACTATGTGGAAGCAGAGAAACTGAGGGGGAGACCGCTGGGGGCAGTGGGCAAGTACAGGGTCAGAAGGAAATTCCCCCTGCCCAGGACAATCTGGGATGGAGAAGAGACCAGTTACTGCTTTAAGGAGAAGTCCCGAGGGGTGCTGAGAGAATGGTATGCCCATAACCCTTACCCGTCTCCCAGGGAGAAGCGGGAGCTGGCTGAGGCCACTGGACTAACCACCACCCAGGTCAGCAATTGGTTCAAGAACAGGAGGCAAAGGGACAGAGCGGCGGAAGCAAAAGAGAGGGAAAATACAGAAAACAATAACACATCTAGCAACAAACAGAATCAGCTGTCACCCCTAGATGGAGGAAAGTCGCTAATGTCCAGTTCAGAAGAGGAATTCTCCCCCCCACAGAGCCCGGATCAGAACTCTGTGCTCCTGTTGCAGGGCAGCCTCACCCACCCCGGCGGCTCCTCTTATTCCCTGAGCGCTCTCAGCGCCTCCCAGGGCGGCCATGGCCTACAGGGGCACCAGCACCAGCTGCAGGACTCTCTGCTTGGGCCCCTCACCTCCAGCCTGGTGGATCTGGGATCGTAAGAGCGACCGCCGGACTCAGCCATGGACTGCACTCTTATTGTACATAGCAAGGCACTCATCTCATGGTACTTAATGTGGAAAGGAAACTGGGACTTTTTATACTTTTCTTCGGTACAATCAATCCCACACAGCACCCCGCACCGCTGAATGCTCTTACGTTACGGCCTCCTGTGGCACTCATATACCCTCTTCCCCCAAATTGCTGTAACAAAATACTGTATAGGAGATACCACAAGGATATAACTGTGTCTTATTTATGAACACCCCTCCCCCCCAAAAAAACAATGTGGTTAAACATGGGAAATCTGGAGAGAATTGCTGTTTGCTCCCACTGTGACACCTAGAATAATTGCCCAGCTATTTGGAGGCGCTAAGTTTACATTTCCCCCCACATTTAGTGTTGAAAGAAGATTGCAAAGTAGTTTATAATAAAATACAGTATTAGAAAGTACAAACCAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088558|Xenopus laevis SIX homeobox 1 (six1), mRNA GGCACGAGTTTCCCTGCACACAGTGCCGTGGATATAGAGAGTGCGCGTGCTCCCCGTGTATGTGTTTGCGTGTGCGCTGTGGGCCCCCGGCTGTGCCACACTGAGCCATGTCTATGCTGCCTTCCTTTGGCTTCACTCAGGAGCAAGTGGCCTGTGTGTGCGAGGTGCTGCAGCAGGGAGGCAACTTGGAGAGACTGGGCAGATTCCTATGGTCCTTGCCAGCCTGCGATCACCTCCACAAGAATGAGAGCGTCCTAAAGGCAAAGGCCGTGGTGGCATTTCACAGGGGCAACTTCAGAGAACTGTACAAGATCCTGGAGAGCCACCAGTTCTCCCCGCACAACCACCCCAAACTGCAGCAACTCTGGCTCAAGGCTCATTATGTGGAGGCAGAGAAACTGAGGGGGAGACCACTGGGGGCAGTGGGCAAGTACAGGGTCAGGAGGAAATTCCCGCTGCCCAGGACCATCTGGGATGGAGAAGAGACCAGTTACTGCTTTAAGGAGAAGTCCCGAGGGGTGCTGAGAGAATGGTATGCCCATAACCCCTACCCGTCTCCCAGGGAGAAGCGGGAGTTGGCTGAGGCCACTGGACTAACCACCACCCAGGTCAGCAATTGGTTCAAGAACAGGAGGCAAAGGGACAGAGCGGCGGAGGCGAAAGAGAGGGAAAATACAGAAAACAATAACACATCTACCAACAAACAGAATCAACTGTCACCCCTAGACGGAGGGAAGTCGCTAATGTCCAGTTCAGAAGAGGAATTCTCGCCCCCACAAAGCCCTGATCAGAACTCGGTGCTCCTGTTGCAGGGCAGCCTCACCCACCCCGGGGCCACCTCTTACTCCCTGAGCGCACTTAGCGCATCGCAGGGCAGTCACGGCTTACAGGGGCACCAGCACCAGCTGCAGGACTCTCTGCTCGGGCCCCTCACCTCCAGCCTGGTGGATCTGGGATCGTAAGAGCGACCGGAACCAGCCATGGACTGCACTCTTATTGTACATAGCAAGGCACTCATCTCATCATGGTACTTAATGTGGAAACAAACTGGGACTTTTTATACTTTTCTTCGGTACAATCAATCCCACAAAGCAGCCCCCCCTGCACCGCTAAATGCTCTTACGTTACGGCCTCCTGTGGCACACACACACCCTCTCCCTCAAAATGCTCTAACAAAATACTGTATAGGAGATACCACAAGGATATAACTGTGTCTTATTTATGAACACCCCCTCCCCCCAAACAATGTGGTTAAATCTGGAGAGAATTGCTGTTTGCTCCCACTGTGACACCTAGAATAATTGCCCAGCTCGTTGGAGGCGCTAAGTTTACATTGCTCCCCCCCCCCCCACATTTAGTGTTGAAAGAAGATTGCAAAGTAGTTTATAATAAAAATACAGTATTAGAAAGCACAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001093693|SIX homeobox 1 [Xenopus (Silurana) tropicalis] MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNTSSNKQNQLSPLDGGKSLMSSSEEEFSPPQSPDQNSVLLLQGSLTHPGGSSYSLSALSASQGGHGLQGHQHQLQDSLLGPLTSSLVDLGS	Refseq >NP_001082027|SIX homeobox 1 [Xenopus laevis] MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNTSTNKQNQLSPLDGGKSLMSSSEEEFSPPQSPDQNSVLLLQGSLTHPGATSYSLSALSASQGSHGLQGHQHQLQDSLLGPLTSSLVDLGS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.64641 [+] Str.53679	Xl.683
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		54 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SIX1	OMIM:608389 OMIM:605192
mouse		MGI	Six1	All(9) Targeted, knock Out(2) Targeted, other(2) Chemically Induced(1)
zebrafish		ZFIN ZFIN	six1b six1a	2 Lines(s)

Publications
First:		Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. [J Biol Chem 2000]
Most recent:		PRC2 during vertebrate organogenesis: A complex in transition. [Dev Biol 2012]
		View All Papers 9 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		multicellular organismal development regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor SIX and related HOX domain proteins

Reagents		tropicalis	laevis
Clones			EXRC - 2 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0			Xl.683.1.S1_at
Affymetrix 2.0			Xl2.683.1.S1_at

Symbol legend[+]

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