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Summary Expression Gene Literature (85) GO Terms (17) Nucleotides (119) Proteins (38) Interactants (959) Wiki
XB-GENEPAGE-480716
Gene Symbol:
six1

Gene Name:
SIX homeobox 1

Synonyms:
XSix1 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Required f...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
branchiootic syndrome [+]

OMIM:
BRANCHIOOTORENAL SYNDROME 1; BOR1 [+]

External Links:
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Xenbase Gene ID XB-GENE-480717 XB-GENE-480721 XB-GENE-17345620
Gene Symbol six1 six1.L six1.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100101702
398185
734994
mRNA RefSeq RefSeq RefSeq
Protein RefSeq RefSeq Swiss-Prot RefSeq
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine six1 six1.L six1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SIX1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Six1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Six1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR six1b six1a ZFIN Ensembl
chicken
GEISHA SIX1 Ensembl
fruit fly
worm
Publications
First Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein., J Biol Chem 2000  
Most Recent Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development., Dis Model Mech 2020                                  
All View All Papers 15 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 8 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 10 terms 0 term
PANTHER six1
KEGG Pathways K15614 K15614
KOG [K] Transcription factor SIX and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks six1
Morpholinos six1 MO1 , six1 MO2 six1 MO1 , six1 MO2 six1 MO1 , six1 MO2
ORFs six1 ORF1 MGC130961 ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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