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XB-GENEPAGE-480799
Gene Symbol:
fzd8
Gene Name: frizzled class receptor 8
Synonyms:
Xfz8
,
Fz-8
,
frizzled-8
,
frizzled 8
,
frizzled8
,
fzd8-a
,
fzd8-b
,
fz8
( Gene Function: transmembrane receptor in the Wnt signaling pathway Protein Function
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Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nucl...[+]
Interactants:
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Diseases: External Links:
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Xenbase Gene ID | XB-GENE-480800 | XB-GENE-865411 | XB-GENE-6254029 | |||||
Gene Symbol | fzd8 | fzd8.L | fzd8.S | Chromosome | Chr6 | chr6L | chr6S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100038274
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373690
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399367
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser) |
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | fzd8 | fzd8.L | fzd8.S | |||||
Phenotype | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Smith Morpholino Screen | tneu087g20 | |||||||
Orthology |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
A role for Xenopus Frizzled 8 in dorsal development., Mech Dev 1998 ![]() |
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Most Recent |
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., J Biol Chem 2020 ![]() |
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All | View All Papers 8 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 10 terms | 6 terms | 7 terms | |||||
PANTHER | fzd8 | |||||||
KEGG Pathways | K02375 | K02375 | K02375 | |||||
KOG |
[T] Smoothened and related G-protein-coupled receptors
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | fzd8 | |||||||
Morpholinos | fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5 | fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5 | fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5 | |||||
ORFs | fzd8 ORF1 | |||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | EXRC Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
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