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Summary Expression Gene Literature (62) GO Terms (11) Nucleotides (136) Proteins (24) Interactants (1144) Wiki
XB-GENEPAGE- 480799

Gene Symbol: fzd8

Gene Name: frizzled class receptor 8

Synonyms: Xfz8 , Fz-8 , frizzled-8 , frizzled 8 , frizzled8 , fzd8-a , fzd8-b , fz8
Add Xenopus synonyms , Nomenclature history


Gene Function: transmembrane receptor in the Wnt signaling pathway

Protein Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nucl...[+]


Interactants: Loading ...

OMIM Disease Associations:
1/5
 
Xenbase Gene ID XB-GENE-480800 XB-GENE-865411 XB-GENE-6254029
Gene Symbol fzd8 fzd8.L fzd8.S
Chromosome scaffold_6 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot Refseq
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.37384 Xl.293 Xl.412
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 48 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine fzd8 fzd8.L fzd8.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tneu087g20      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards FZD8 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Fzd8 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN fzd8a fzd8b ZFIN Ensembl
chicken
GEISHA FZD8 Ensembl
fruit fly
worm
WORMBASE
Publications
First: A role for Xenopus Frizzled 8 in dorsal development. [Mech Dev 1998]
Most recent: Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. [Dev Cell 2017]
View All Papers 7 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 6 terms 0 term
EC
PANTHER fzd8
KEGG Pathways K02375 K02375
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s) EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5 fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5 fzd8 MO1 , fzd8 MO2 , fzd8 MO3 , fzd8 MO4 , fzd8 MO5
Affymetrix 1.0 Str.37384.1.S1_at Xl.293.1.S1_at Xl.412.1.S1_at
Affymetrix 2.0 Xl2.293.1.S1_at Xl2.412.1.S1_at

Symbol legend[+]

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