Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (165) GO Terms (25) Nucleotides (182) Proteins (44) Interactants (428) Wiki
XB-GENEPAGE-481306
Gene Symbol:
smad6

Gene Name:
SMAD family member 6

Synonyms:
madh6 , Xsmad6 ( Add synonyms , Nomenclature history )

Gene Function:
signal transduction, TGF-beta pathway

Protein Function :



Interactants:
Loading ...

Diseases: 


Disease Ontology:
aortic valve stenosis

OMIM:
AORTIC VALVE DISEASE 2; AOVD2 [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-481307 XB-GENE-481311 XB-GENE-17331300
Gene Symbol smad6 smad6.L smad6.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038072
399369
100037050
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine smad6 smad6.L smad6.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tgas073h08      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SMAD6 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Smad6 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Smad6 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR smad6a smad6b ZFIN Ensembl
chicken
GEISHA SMAD6 Ensembl
fruit fly
worm
Publications
First Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nature 1997  
Most Recent Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020                        
All View All Papers 4 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 24 terms 8 terms 8 terms
PANTHER smad6
KEGG Pathways K04677 K04677 K04677
KOG [TK] TGFbeta receptor signaling protein SMAD and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks smad6
Morpholinos smad6 MO1 , smad6 MO2 smad6 MO1 , smad6 MO2 smad6 MO1 , smad6 MO2
ORFs smad6.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list