Gene Symbol: frzb Gene Name: frizzled-related protein Synonyms: Frzb-1, xfrzb, fre, os1, fzrb, fiz, fritz, frp-3, frzb1, sfrp3, srfp3, frzb-pen Add Xenopus synonyms Gene Function: secreted wnt antagonist Interactants: wnt8a(21) , szl(15) , chrd(14) , cer1(12) , dkk1(11) , t(11) , frzb2(9) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001005438|Xenopus (Silurana) tropicalis frizzled-related protein (frzb), mRNA GAACAAGGGGCACTTTCACAGGACTCCTGGCAGCAGAGGTGAATGGCTAGCCCTATGGATATGGCTTGCTGATTTTGATAAATGATTGATTGCTTTCAGATAGGCAGCACTGCAGAACTTTTCATGGATTTTCATCTTATTCTGCACTTTTAAATTATCTGGGTAATTGTTAGTATTGCCTTGGGTGGGACTAAAGGCAAACTTAACGCCTTGCATTTGAGTTGAACTAGAACTATAAGGTGGAGTGAGTTATAGTTGCTTTGCATGTGCCCAGATCTTCCCTGTATACAGAGTCCCTGTATTACACCCAGAGTGAGCCTACGCTTACAGGTGATAGCTTGGGCAGGATAACAATGTCTCCGACAGGGAAGGTGGACTCATTTCTGCTAATGGTCATACCGGGGCTGGTGCTCCTATCATTACCCAACGCTCACTGTGCTTCATGTGAGCCTGTGCGGATTCCCATGTGCAAATCTATGCCATGGAACATGACTAAAATGCCCAACCATCTCCACCACAGCACTCAAGCCAATGCCATTTTGGCAATTGAACAGTTTGAAGGTTTGCTGACCACTGAATGTAGCCAGGACCTTCTGTTCTTTCTGTGTGCTATGTATGCCCCCATTTGTACCATCGATTTCCAGCACGAGCCAATTAAGCCTTGCAAATCTGTATGTGAAAGGGCCAGGGCCGGCTGTGAGCCCATTCTCATCAAGTACCGGCACACTTGGCCAGAGAGCCTGGCATGTGAGGAGCTCCCCGTATATGACAGAGGAGTCTGCATCTCCCCAGAGGCTATCATCACGGTGGAACAAGGAACAGATTCGATGCCAGACTTCCCCATGGATTCAAACAACGGAAATTGTGGAAGCACGGCAGGGGAGCACTGTAAATGCAAGCCCATGAAGGCTTCCCAAAAGACGTATCTCAAGAATAATTACAATTATGTAATCAGAGCAAAAGTGAAAGAGGTGAAAGTGAAATGCCACGACGCAACAGCAATTGTGGAAGTAAAAGAGATTCTCAAGTCTTCCCTAGTAAATATTCCTAAAGACACAGTAACACTATATACCAACTCAGGCTGCTTGTGCCCCCAGCTTGTTGCCAATGAGGAATATATAATTATGGGATACGAAGACAAAGAGCGCACCAGGCTTCTATTAGTGGAAGGATCCTTGGCTGAAAAATGGAGAGATCGCCTTGCTAAGAAAGTCAAGCGTTGGGATCAGAAACTTCGACGTCCTAGGAAAAGCAAAGACCCCGTGGCCCAAAATACCAACAAAAACAGCAATTCCAGACAAGCACGTAGTTAGACGAATGGAAAGGTGTATGGAAATTCCATGGACTTTAATACTAAGATTTGCATTGTTGGAAGAGCAAAGAAGAAATTGCACTACAGCACGTTATATTCTATTGTTTACTACAAGAGGCTGGTTTAGTTGATTGTAGTTCCCCCTTTCCTTTTTTTTATAATTATATTTGCACGTGTTCCCGGGCAATTGTTTTATTCAACTTCAAGTGGCAGAACGGTGACCGAACATCTAGGCCTGATGAAGCACAATTCATTTCTGATCGACCAATGGTGACGAGTGTGTGATACTTTGCCAAAGTGATATGATTGCAATGGTTGGCCAATGTTGCTTCTTCTTTAGATGAACAAATGAGAGATCACATTGAATGACGGCTTTGATCACTTTCCATTTAATACTTTTAGTTAGACAATAAGTGGGGTGTGCCTAAATTTGAATATTTTGTCTGGTTCAGACTGTATGGTCTCTGTGGGGAAGGTAAATACCTGCTTTGTCAATTCTGTTTTAAAAATTGCCTGAATAAATATTAAGTCCTAAATATCAAAAAAAAAAAAAAA	Refseq >NM_001096446|Xenopus laevis frizzled-related protein (frzb), mRNA GGCACTTTCACAGGACTCCTGGCAGAGGTGAATGGCTAGCCCTATGGATTTGGCTTGTTGATTTTGACAAATGATTGATTGCTTTTAGACAGACAGCGCTGAAGGACTTTTAGTGGATTTTTATTTAATTCTGCACTTTTAAATTGCCTGGGAAATTGTTAATATTGTATTGGATGGGACTAAAGGTAAACTTAACTCCTTGCTTTTGACTTGACCTAAAACTATAAGGTGGGGTGAGTTATAGTTAGTTGCTTTGCATGTGCCCAGAACTTCCCTGTAAATCAAGGCAACCTGCAGTCACCCCATAGTAAGCCTACACATACAGGTATTAACTTGAGCAGAATAACAATGTCCACAACAAGGAACAAGGACACATTCCAGCTACTGGTCATACCTTGGCTAGTGCTCCTCTTATTACCTAGCGCTTTCTGTGCTTCGTGTGAACCTGTGCGGATTCCCATGTGCAAATCTATGCCATGGAACATGACTAAGATGCCCAACCATCTCCACCACAGCACTCAAGCCAATGCCATCCTGGCAATTGAACAGTTTGAAGGTTTGCTGACAACTGAATGTAGCCAGGACCTTCTGTTCTTTCTGTGTGCCATGTATGCCCCCATTTGTACCATCGATTTCCAGCATGAGCCAATTAAGCCTTGCAAGTCCGTGTGTGAAAGAGCCAGGGCTGGCTGTGAGCCCATTCTCATCAAGTACCGGCACACTTGGCCAGAGAGCCTGGCATGTGAGGAGCTGCCCCTATATGATAGAGGAGTCTGCATCTCCCCAGAGGCTATCATCACAGTGGAACAAGGAACCGATTCGATGCCAGACTTCTCCATGGATTCAAACAAAGGAAACTGTGGAAGCACAGCCGGTGAGCATTGTAAATGCAAGCCCATGAAGGCTTCCCAAAAGACATATCTCAAGAATAATTACAATTATGTAATCAGAGCAAAAGTGAAAGAGGTGAAAGTGAAATGCCATGATGCAACAGCAATTGTGGAAGTAAAGGAGATTCTCAAGTCTTCCCTAGTGAACATTCCTAAAGACACAGTGACACTGTACACCAACTCAGGCTGCTTGTGCCCCCAGCTTGTTGCCAATGAAGAATACATAATTATGGGGTATGAAGATAAAGAGCGTACCAGGCTTCTATTAGTGGAAGGATCCTTGGCCGAAAAATGGAGAGATCGTCTTGCTAAGAAAGTCAAGCGTTGGGATCAAAAGCTTCGACGTCCTAGGAAAAGCAAAGACCCAGTGGCTTCAAATACCAACAAAAACAGCAATTCCAGACAAGCACATAGTTAGAGTAATGGAAAGATATATGGAAACTCCATGAACTTTAATACTAAGATTTGCATTGTTGGAAGAGCAGAGAAGAAATTGCACTACGGCACGTTATATTCTATTGTTTACTACAAGAGGCTGGTTTAGTTGATTGTAGTTCCCCTTTCCTTCTTTTTTTACAACTATATTTGCACGTGTTCCCAGGCAATTATTTTAGTTCAACTTCCAGCTAGCAGAGCAGTGACTGAATGTCTCAGCCTGATGAAGCTCAGTTTATTTCTGATCGACTAATGGTGACAAGTGTTTGATACTTTGCCAAAGGGACGCGATTGCTGTGGTAAATCAGAGAGAGAGAAAAAAGTTGACCAATGTTGCTTCTTCTGTAGATGAACAAATGAGATATCACATTGAAATGATGGCTTTGATCACTTTCCGTTTAATATTTTTCAGCATTTTTAGTTAGACAACATGTGGCATGTGCCTGAATCTGAATATTTTATTATAAATGAAGAGCTGGCTTAGACTGTATGGTCTCTGTTGGGAAAGGAAATGCCTACTTTGTCAATTCTGTTTTAAAAATTGCCTAAATAAATATTAAGTCCTACAAAAAAAAAAAAAAA
Protein		Refseq >NP_001005438|frizzled-related protein precursor [Xenopus (Silurana) tropicalis] MSPTGKVDSFLLMVIPGLVLLSLPNAHCASCEPVRIPMCKSMPWNMTKMPNHLHHSTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPILIKYRHTWPESLACEELPVYDRGVCISPEAIITVEQGTDSMPDFPMDSNNGNCGSTAGEHCKCKPMKASQKTYLKNNYNYVIRAKVKEVKVKCHDATAIVEVKEILKSSLVNIPKDTVTLYTNSGCLCPQLVANEEYIIMGYEDKERTRLLLVEGSLAEKWRDRLAKKVKRWDQKLRRPRKSKDPVAQNTNKNSNSRQARS	Refseq >NP_001089915|frizzled-related protein precursor [Xenopus laevis] MSTTRNKDTFQLLVIPWLVLLLLPSAFCASCEPVRIPMCKSMPWNMTKMPNHLHHSTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPILIKYRHTWPESLACEELPLYDRGVCISPEAIITVEQGTDSMPDFSMDSNKGNCGSTAGEHCKCKPMKASQKTYLKNNYNYVIRAKVKEVKVKCHDATAIVEVKEILKSSLVNIPKDTVTLYTNSGCLCPQLVANEEYIIMGYEDKERTRLLLVEGSLAEKWRDRLAKKVKRWDQKLRRPRKSKDPVASNTNKNSNSRQAHS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.7018 [+] Str.30612	Xl.55584
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		39 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	FRZB	OMIM:165720
mouse		MGI	Frzb	All(6) Targeted, other(3) Targeted, knock Out(1)
zebrafish		ZFIN	frzb

Publications
First:		Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network. [Development 1990]
Most recent:		Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells. [Genesis 2012]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		transmembrane receptor activity
Biological:		multicellular organismal development
Cellular Component:		membrane
EC:
KOG:		[T] Smoothened and related G-protein-coupled receptors

Reagents		tropicalis	laevis
Clones		EXRC - 3 clone(s)	EXRC - 2 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.7018.1.S1_at [+] Str.30612.1.A1_at	Xl.1929.1.A1_at
Affymetrix 2.0			Xl2.55584.1.S1_at

Symbol legend[+]

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