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Summary Expression Gene Literature (27) GO Terms (19) Nucleotides (92) Proteins (30) Interactants (182) Wiki
XB-GENEPAGE- 481425

Gene Symbol: hand2

Gene Name: heart and neural crest derivatives expressed 2

Synonyms: dhand , dhand2 , xhand2 , hand2-a , hand2-b
Add Xenopus synonyms , Nomenclature history


Gene Function: basic helix-loop-helix transcription factor

Protein Function:
Essential for cardiac morphogenesis and for the development of branchial arches. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.


Interactants: YYY

OMIM Disease Associations:
1/6
 
Xenbase Gene ID XB-GENE-481426 XB-GENE-865126 XB-GENE-6252408
Gene Symbol hand2 hand2.L hand2.S
Chromosome scaffold_1 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.43435 Xl.770 Xl.771
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 29 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine hand2 hand2.L hand2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards HAND2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Hand2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN hand2 ZFIN Ensembl
chicken
GEISHA HAND2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. [Dev Biol 1998]
Most recent: Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis. [Dev Biol 2017]
View All Papers 4 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 14 terms 6 terms 1 terms
EC
PANTHER hand2
KEGG Pathways K18486 K18486 K18486
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino hand2 MO1 hand2 MO1 hand2 MO1
ORF hand2 ORF1
Affymetrix 1.0 Str.24376.1.S1_at [+] Xl.770.1.S1_at Xl.771.1.S1_at
Affymetrix 2.0 Xl2.770.1.S1_at Xl2.771.1.S1_at

Symbol legend[+]

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