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Summary Expression Gene Literature (32) GO Terms (27) Nucleotides (117) Proteins (48) Interactants (453) Wiki
XB-GENEPAGE-481425
Gene Symbol:
hand2

Gene Name:
heart and neural crest derivatives expressed 2

Synonyms:
dhand , dhand2 , xhand2 , hand2-a , hand2-b ( Add synonyms , Nomenclature history )

Gene Function:
basic helix-loop-helix transcription factor

Protein Function :
Essential for cardiac morphogenesis and for the development of branchial arches. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.


InterPro :
WD40 repeat , WD40 repeat dom , WD40 repeat dom sf , Mediator Med16 [+]

Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-481426 XB-GENE-865126 XB-GENE-6252408
Gene Symbol hand2 hand2.L hand2.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100101704
373641
373833
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hand2 hand2.L hand2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards HAND2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Hand2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Hand2 Ensembl
zebrafish
ZFIN, AGR hand2 ZFIN Ensembl
chicken
GEISHA HAND2 Ensembl
fruit fly
worm
Publications
First A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice., Dev Biol 1998  
Most Recent Id genes are essential for early heart formation., Genes Dev 2017                  
All View All Papers 5 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 25 terms 4 terms 1 terms
PANTHER hand2
KEGG Pathways K18486 K18486 K18486
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hand2
Morpholinos (on-target & off-target) hand2 MO1 hand2 MO1 hand2 MO1
ORFs hand2 ORF1 hand2.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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