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Summary Expression Gene Literature (29) GO Terms (19) Nucleotides (96) Proteins (31) Interactants (419) Wiki
XB-GENEPAGE- 481425

Gene Symbol: hand2

Gene Name: heart and neural crest derivatives expressed 2

Synonyms: dhand , dhand2 , xhand2 , hand2-a , hand2-b
Add Xenopus synonyms , Nomenclature history

Gene Function: basic helix-loop-helix transcription factor

Protein Function :
Essential for cardiac morphogenesis and for the development of branchial arches. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.


Interactants: Loading ...

Disease Ontology:
  

OMIM Diseases:
  
1/6
 

Xenbase Gene ID XB-GENE-481426 XB-GENE-865126 XB-GENE-6252408
Gene Symbol hand2 hand2.L hand2.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus PANTHER
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.43435 Xl.770 Xl.771
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 29 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine hand2 hand2.L hand2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards HAND2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Hand2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR hand2 ZFIN Ensembl
chicken
GEISHA HAND2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. [Dev Biol 1998]
Most recent: Id genes are essential for early heart formation. [Genes Dev 2017]
View All Papers 4 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 14 terms 6 terms 1 terms
PANTHER hand2
KEGG Pathways K18486 K18486 K18486
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino hand2 MO1 hand2 MO1 hand2 MO1
ORF hand2 ORF1 , hand2 ORF1 hand2.L ORF1
Affymetrix 1.0 Str.24376.1.S1_at [+] Xl.770.1.S1_at Xl.771.1.S1_at
Affymetrix 2.0 Xl2.770.1.S1_at Xl2.771.1.S1_at

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556