hand2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (18)

Nucleotides (92)

Interactants (101)

XB-GENEPAGE-481425

Gene Symbol: hand2 Gene Name: heart and neural crest derivatives expressed 2 Synonyms: dhand, dhand2, xhand2 Add Xenopus synonyms Gene Function: basic helix-loop-helix transcription factor Interactants: nkx2-5(9) , bmp4(5) , hand1(4) , shh(4) , gli3(3) , mef2c(3) , tbx5(3) View All

XB-GENE-481426

XB-GENE-865126

XB-GENE-6252408

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001100225\|Xenopus (Silurana) tropicalis heart and neural crest derivatives expressed 2 (hand2), mRNA GGAGAGTGTGCCAGTGCCGAGCGTTCCGTGCAGGTCTATGGGGTGCGAGAAGGACACTGGGAGGCATCACTGATCTCCATGCCGACACAGAGAGCCAAGAAGACAGATGTGCGCACCCCAGGCACTCCCACCTTTTCTGTCTGTGGGGTGTATTGGGAGCAGGGACCCCTGTGAGACGCAGGGAATGGGTGCCAGCTCGCAGTGAAACCTGATCGCAAAGCCTTAGCTGCAGGGACATCCCATTGAGGACTATGGACCAGACCTGCTGTAAGTAAGAGATCGCTCATCCAGCTGTTCTATGGGCACAATCGCACTGGAGCCAACTGCACCCATGAGAGTATGCCCCATCTTACTTGAAATCGCAGCGTCTGCAACGATTTGCTGCTTCTTATACACAGGCGTTTTGCTCTGCTCAGAAAACTTTTCTTTTCGATAACAAGAGAGACTGTGGATTTATTTATGGAGAGCCAGGGATAATATATTTAATATACTACAGCACTGTTTATTTATACATAGATTGCCAGCGGGAGGACTAGAAGCACACAGACAAGACTAGCCAGGAAGCCCAGCTGACATGAGTCTGGTTGGGGGGTTTCCCCACCACCCGGTGGTGCACCATGACGGTTATCCTTTTGCAGCTGCCGCAGCTGCAGCCGCCAGTCGCTGCCACGAAGAGAACCCTTATTTCCACGGCTGGCTAATCAGCCACCCCGAGATGTCTCCCCCCGACTACAGCATGGCACCGTCCTACAGCCCAGAGTACGCCAATGGCGCGGCCGGGCTGGACCACTCCCATTACGGGGGTGTCCCGGGAAGCGGGGCAGGAGGCTTAATGCAACGGCCTGTAAAGAGAAGGGGAACCGCTAACCGCAAGGAAAGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCAGAACTGCGGGAGTGTATCCCCAATGTGCCAGCGGATACTAAGCTCTCAAAGATCAAAACTCTGCGCCTGGCCACCAGCTACATTGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAATGGAGAGACAGAGGCCTTTAAGGCAGAGATCAAAAAGACAGATGTGAAGGAGGAGAAAAGGAAGAAAGAACTGAACGAACTTTTGAAAAGCACAGTTTGCAGTAACGATAAGAAAACCAAAGGCAGGACTGGTTGGCCGCAACATGTCTGGGCTCTGGAGCTTAAACAGTGACCCTCTGGGACTGCAGGAGAGGAGCCTCTCTATGTATCTGTACGTGTCCTAAAATAATAACTCTGTATTTGGAATGGTCCATTTTTATTTATGTGCAATTTTCCCAAGGACCCACCCAATGTGGATCTCCGCAGAGAAACATTCCAGAAAGTGAAGAGGAGTCTGCAGGTTGGTACAGGGGCTGTGTCTGTCTGTCGCAGTTTGTGATTGTTACAGTAATTTCTCTGTCGCAAAAACAAAAGACTCCCTGGCATTACTGTGTATGTGAAGTGTATCCCTTTCTTACAAAAAATAATAAACAAAGTGGCCTCTTTTGGTTAGAGATCTTCCTCGGATGCTACAAAAGTCAGTTCCTTCAGAAACAGCTGCGACTTTGTTTCGGTTGCGTTATTAACCCTTCCCATGCCGCGGGCAGAAATACGCACTTTCTTCTTTTTTTTCCCGTTTATATTTTGCGTTCCTGTGGCGAGAGGAAGGATTTCATGTTGCCAGATCATTTGGTGACACTGAAACATTTGAAGGTGTTTTCATCAAGTTGTTTTTGTGCACTTCTGTCCAGATATGTGGAGTTTAAATATTTGAAGGTGTAAAAATGTTGTAAGTGATCAATAAACCACTGAGTGTTTTTTTTTATTTTGTTTAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001085639\|Xenopus laevis heart and neural crest derivatives expressed 2 (hand2-a), mRNA GGTCTATGGGGTACGTGGAGGACACTGGGAGGCATCACTAATGTCCATGCCGACAAAGAGAGCCGACAAGACACCCCAGCAGCAGGCACTCCCACCTTTTGTGTCTGTGGGTGAATTGGGAGCGTGTGAGGTGCAGGGAATGGGAACCAGTTCGCACTGAAACCTGATCACAAAGCCTTTACTGCAGGGACATCCCATTGAGGACTATGGAGCTGGTGTAAGTAACAGATCGCTCCTCCATGCAGCTGTTCTATGGGCACAATCGCACTGGAGCCGACTGCACCCATGAAAGCTTGCCTCAGTTTACTTGAAATCGCAACGTTTTGCTGCTTCTCACACGCGGGCGTTTTTGCTCTGTCCAGAAAACTTTCGGTAATAAGAGTGAGAGACTGACTGTGGATTTATTTATGGAGAGCCAGTGATAACCTATTGAACACACGACACCAGCACTGTCTGTTTATACATAGATTGTCAGCAGGAGGACAAGAAGCGCCCAGACAAGACTATAGACAAGTGTAGCTGAGATGAGTCTGGTTGGGGGGTTTCCACACCACCCAGTGGTTCACCATGACGGTTATCCCTTTGCAGCTGCGGCAGCTGCAGCCGCCAGTCGCTGCCATGAAGAGAACCCTTATTTTCACGGCTGGCTAATTAGCCACCCCGAAATGTCTCCCCCCGATTACAGCATGGCACCGTCCTACAGCCCGGAGTATGCCAATGGCGCGGCCGGACTGGACCACTCCCATTACGGGGGTGTCCCGGGAAGCGGGGCAGGAGGCTTGATGCAACGGCCTGTAAAGCGAAGGGGAACCGCTAACCGCAAGGAAAGGCGCAGGACTATAAGCATCAACAGCGCCTTCGCAGAGCTGAGGGAGTGTATCCCCAATGTGCCCGCGGATACCAAGCTCTCAAAGATCAAAACTCTGCGGCTGGCCACCAGCTATATAGCCTACCTCATGGACCTGCTGGCCAAAGACGACCAGAATGGCGAGACAGAGGCCTTTAAGGCAGAGATCAAAAAGACAGATGTGAAGGAGGAAAAGAGGAAGAAAGAACTGAATGAACTATTGAAAAGCACAGTTTGCAGTAACGATAAGAAAACCAAAGGCAGGACTGGTTGGCCGCAACATGTCTGGGCTCTGGAGCTAAAACAGTGACCCTGGGGGACTGGAGTCGAGAAGACCCTTTATGTATCTGTGTCCTAAAATAATAACTCTGTATTTGGAATGGTCCATTTTTATTTATGTGCAATTTCCCCAATGACCCCCCCTACCCAACCCCCAATGTGGATCTCCGAAGAGAAACATTCCAGAAAGTGTAGAGGAGTCTGCAGGTTGGTACAGGGGCTGTGTGTCTGTTTGTCGCAGTTTGTGATTGTTACAGTATTTCTGTCGCAAAACAAAGACTCCCTGGCATTACTGTGTATGTGAAGTGTATCTCTCTTTCTCTCTCTCTTTCTCTTACAAAAAAAAAAATAATAAACAAAGTGGCCTCTTTTGGTTAGAAAAAAAAAATCTTCCTCGGATGTGACAAAGTCAATTCCTACAGAAACAGCTGCGACTTTGTGTCGGTTTGCGGTGTTAACCCTTTCCGTTCCACGGGCAGAAATGCGCACTTTTTCCCCTTTGTTTTTATTTTATTTTTGCGTCGTCCCCCCGTGACAAGAGGAAGGGTTTCATGTTGTCAGATCATTTGGTGACACTAAAAACATTTTGAAGGTGTTTTCATCGCATTGTTTTGTGCTCTTATCTGTCCAGATATGTGGAGTTTAAATATTTGAAGGTGTAAAAAAATGTTGTAAGTGATCAATAAACCACTGAGTGTTTTTTTTTTAAAAAA		Refseq >NM_001114193\|Xenopus laevis heart and neural crest derivatives expressed 2 (hand2-b), mRNA TGCAGCTCTTCTACGGGCACAATCGCACAGGAGCCAAATGAGAGCATGTCCCGGCTTACTTGAAATCGCAGCGTCTGCAACGTTATTGCTGCTGCTTCTCACACACACTCTGTTCAGAAAACGTTTCGATAATAAGAGTAAGAGAGACTGACTGTGGATTTATTAATGGAGAGCCAGGGATAACCTATATTTAATACATAGATTGCCGGCGGGAGGACAAGACTATAGTGTAGCTGACATGAGTCTGGTTGGGGGGTTTCCTCACCACTCAGTGGTGCACCATGACGGTTATCCTTTTGCAGCTGCTGCTGCAGCCGCTAGTCGCTGCCACGAAGAGAACCCTTATTTCCACGGCTGGCTAATCAGTCACCCCGAAATGTCTCCCCCCGACTACAGCATGGCACCGTCTTACAGCCCGGAGTACGCCAATGGCGCGGCCGGCCTGGACCACTCCCATTACGGGGGAGTCCCGGGAAGCGGCGCAGGAGGCTTGATGCAACGGCCTGTAAAGCGAAGGGGGACCGCTAACCGCAAGGAAAGGCGCAGGACTCAAAGCATCAACAGCGCCTTCTCAGAGCTGCGGGATTGTATCCCCAATGTGCCGGCCGATACCAAACTGTCAAAGATCAAAACTCTGCGGCTGGCCACCAGCTATATAGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAATGGGGAGACAGAGGCCTTTAAGGCAGACATCAAAAAGACAGATTTGAAGGAGGAGAGGAGGAAGAAAGAAATGAACGAACTTTTGAAAAGCACAGTTTGCAGTAACGATAAGAAAACCAAAGGAAGGACTGGTTGGCCGCAACATGTCTGGGCTCTGGAGCTAAAACAGTGACCCTGGGGGATGGGGGGAACCTTTATGTATCTGTACGTGTCCCTGAAATAATAACTGTATTTGGAATGGTCCATTTTTATTTATGTGCAATTGTCCCTCCTTCCAACGTGGATCTTCCGCAGAGAAACATTCCAGAATACGAAGAGGAGTGTGCAGGTTGGTACAGGGGGCAGGGCTGTGTCTGTCTGTCGCAGTATGTGATTGTTACAGTATTTCTCTGTCGCAAAACAAAGACTCCCTGGCTACTGTGTATGTGAAGTTTATCCGTCTCTTTACAAAACAATAATAATAATAAACAAAAATGGCTTCGTTTTGGTTCGAAATCGTCCTCGGATGCTACAAAGTCAATTCCTACAGAAACAGCTGCGACTTTTGTTTCGGTTAACCCTTCCAGTGCCACGGGCAGAATTTTTCCCACTTTGTTTTTTTTTGGGTTTTTTTGCGTTCAAGAGGAAGGATTTCATGTTACCAGTTCATTGAAGGTGTTTTCATCGAATTGTTTTGTGCACTTCTGTCCAGATATGTGGACTTTAATATTTGAAGGCGTAAAAATGTTGTAAGTCATCAATAAACCACTGAGTGTTTTTTTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001093695\|heart and neural crest derivatives expressed 2 [Xenopus (Silurana) tropicalis] MSLVGGFPHHPVVHHDGYPFAAAAAAAASRCHEENPYFHGWLISHPEMSPPDYSMAPSYSPEYANGAAGLDHSHYGGVPGSGAGGLMQRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGETEAFKAEIKKTDVKEEKRKKELNELLKSTVCSNDKKTKGRTGWPQHVWALELKQ	Refseq >NP_001079108\|heart- and neural crest derivatives-expressed protein 2 [Xenopus laevis] MSLVGGFPHHPVVHHDGYPFAAAAAAAASRCHEENPYFHGWLISHPEMSPPDYSMAPSYSPEYANGAAGLDHSHYGGVPGSGAGGLMQRPVKRRGTANRKERRRTISINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGETEAFKAEIKKTDVKEEKRKKELNELLKSTVCSNDKKTKGRTGWPQHVWALELKQ UniProtKB		Refseq >NP_001107665\|heart and neural crest derivatives expressed 2 [Xenopus laevis] MSLVGGFPHHSVVHHDGYPFAAAAAAASRCHEENPYFHGWLISHPEMSPPDYSMAPSYSPEYANGAAGLDHSHYGGVPGSGAGGLMQRPVKRRGTANRKERRRTQSINSAFSELRDCIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGETEAFKADIKKTDLKEERRKKEMNELLKSTVCSNDKKTKGRTGWPQHVWALELKQ

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.43435	Xl.770		Xl.771
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		13 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	HAND2
mouse		MGI	Hand2	All(9) Targeted, knock Out(3) Targeted, other(6)
zebrafish		ZFIN	hand2	23 Lines(s)

Publications
First:		A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. [Dev Biol 1998]
Most recent:		Imparting regenerative capacity to limbs by progenitor cell transplantation. [Dev Cell 2013]
		View All Papers 2 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:
Cellular Component:
EC:
KOG:		[K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1

Reagents		tropicalis	laevis a		laevis b
Clones		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.24376.1.S1_at [+] Str.43435.1.A1_s_at Str.43435.1.A1_x_at	Xl.770.1.S1_at		Xl.771.1.S1_at
Affymetrix 2.0			Xl2.770.1.S1_at		Xl2.771.1.S1_at

Symbol legend[+]