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XB-GENEPAGE-481425
Gene Symbol:
hand2
Gene Name: heart and neural crest derivatives expressed 2
Synonyms:
dhand
,
dhand2
,
xhand2
,
hand2-a
,
hand2-b
( Gene Function: basic helix-loop-helix transcription factor Protein Function
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Essential for cardiac morphogenesis and for the development of branchial arches. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Interactants:
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Diseases: External Links:
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Xenbase Gene ID | XB-GENE-481426 | XB-GENE-865126 | XB-GENE-6252408 | |||||
Gene Symbol | hand2 | hand2.L | hand2.S | Chromosome | Chr1 | chr1L | chr1S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100101704
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373641
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373833
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | hand2 | hand2.L | hand2.S | |||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice., Dev Biol 1998 |
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Most Recent |
Id genes are essential for early heart formation., Genes Dev 2017 ![]() |
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All | View All Papers 5 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 25 terms | 4 terms | 1 terms | |||||
PANTHER | hand2 | |||||||
KEGG Pathways | K18486 | K18486 | K18486 | |||||
KOG |
[K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | hand2 | |||||||
Morpholinos (on-target & off-target) | hand2 MO1 | hand2 MO1 | hand2 MO1 | |||||
ORFs | hand2 ORF1 | hand2.L ORF1 | ||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
Symbol legend:



