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Summary Expression Gene Literature (12) GO Terms (15) Nucleotides (70) Proteins (28) Interactants (93) Wiki
XB-GENEPAGE-481464
Gene Symbol:
kremen1

Gene Name:
kringle containing transmembrane protein 1

Synonyms:
kremen , kremen 1 , krm1 ( Add synonyms , Nomenclature history )

Gene Function:
dickkopf receptor

Protein Function :
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.


InterPro :
Sperma CUB dom sf , CUB dom , WSC carb-bd , CTDL fold [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
ectodermal dysplasia 13

OMIM:
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE; ECTD13

External Links:
 
Xenbase Gene ID XB-GENE-481465 XB-GENE-17346146 XB-GENE-865130
Gene Symbol kremen1 kremen1.L kremen1.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100144698
108717089
398249
mRNA RefSeq NCBI Nucleotide RefSeq
Protein RefSeq NCBI Protein RefSeq Swiss-Prot
Genomic
 tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine kremen1 kremen1.L kremen1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards KREMEN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Kremen1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Kremen1 Ensembl
zebrafish
ZFIN, AGR kremen1 ZFIN Ensembl
chicken
GEISHA KREMEN1 Ensembl
fruit fly
worm
Publications
First Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning., Development 2002          
Most Recent [New Development in Osteoporosis Treatment. Anti-Dickkopf1 (Dkk1) antibody as a bone anabolic agent for the treatment of osteoporosis]., Clin Calcium 2014  
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 3 terms 3 terms
PANTHER kremen1
KEGG Pathways K23091 K23091 K23091
KOG [GO] beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks kremen1
Morpholinos kremen1 MO1 kremen1 MO1 kremen1 MO1
Clones Horizon Source BioScience Horizon Horizon Source BioScience

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