Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (97) GO Terms (47) Nucleotides (121) Proteins (23) Interactants (737) Wiki
XB-GENEPAGE-481819
Gene Symbol: lrp6

Gene Name: LDL receptor related protein 6

Synonyms: Xlrp6 , adcad2 , lrp6-a , lrp6-b ( Add synonyms , Nomenclature history )

Gene Function: signal transduction

Protein Function :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.

Interactants: Loading ...
Disease Ontology: coronary artery disease

OMIM Diseases: CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2 [+]

 
Xenbase Gene ID XB-GENE-481820 XB-GENE-6252411 XB-GENE-865490
Gene Symbol lrp6 lrp6.L lrp6.S
Chromosome scaffold_269 Scaffold31 chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide NCBI Nucleotide RefSeq
Protein NCBI Protein TrEMBL TrEMBL NCBI Protein RefSeq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine lrp6 lrp6.L lrp6.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards LRP6 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Lrp6 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
lrp6 ZFIN Ensembl
chicken
GEISHA LRP6 Ensembl
fruit fly
worm
WORMBASE
Publications
First LDL-receptor-related proteins in Wnt signal transduction., Nature 2000  
Most Recent PTK7 proteolytic fragment proteins function during early Xenopus development., Dev Biol 2019          
All View All Papers 17 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 47 terms 0 term 7 terms
PANTHER lrp6
KEGG Pathways K03068 K03068
KOG [T] Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Antibody Lrp6 Ab1 , Lrp6 Ab2 Lrp6 Ab1 , Lrp6 Ab2 Lrp6 Ab1 , Lrp6 Ab2
Morpholino lrp6 MO1 , lrp6 MO2 lrp6 MO1 , lrp6 MO2 lrp6 MO1 , lrp6 MO2
Affymetrix 1.0 StrJgi.6534.1.S1_at [+] Xl.21550.1.S1_at [+] Xl.20919.1.S1_at
Affymetrix 2.0 Xl2.21550.1.S1_at [+] Xl2.20919.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.0


Major funding for Xenbase is provided by grant P41 HD064556