Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (81) GO Terms (7) Nucleotides (77) Proteins (35) Interactants (850) Wiki
XB-GENEPAGE-481991
Gene Symbol:
smad3

Gene Name:
SMAD family member 3

Synonyms:
XSmad3 , XenMLP ( Add synonyms , Nomenclature history )

Gene Function:
signal transduction, TGF-beta pathway

Protein Function :


InterPro :
SMAD FHA dom sf , SMAD MH1 sf , Dwarfin , MAD homology MH1 [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Loeys-Dietz syndrome

OMIM:
LOEYS-DIETZ SYNDROME 3; LDS3

External Links:
1/4
 
Xenbase Gene ID XB-GENE-481992 XB-GENE-864816 XB-GENE-17345125
Gene Symbol smad3 smad3.L smad3.S
Chromosome Chr03 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 493272
378633
108712801
mRNA RefSeq RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine smad3 smad3.L smad3.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu050m05      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SMAD3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Smad3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Smad3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR smad3a smad3b ZFIN Ensembl
chicken
GEISHA SMAD3 Ensembl
fruit fly
worm
Publications
First Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways., Nature 1996  
Most Recent Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm., Genes (Basel) 2019          
All View All Papers 14 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 7 terms 7 terms 6 terms
PANTHER smad3
KEGG Pathways K04500 [+] K04500 [+] K23605
KOG [TK] TGFbeta receptor signaling protein SMAD and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks smad3
Antibodies Smad3 Ab1 , Smad3 Ab2 , Smad2 Ab8 , Smad2 Ab9 , Smad2/3 Ab1 Smad3 Ab1 , Smad3 Ab2 , Smad2 Ab8 , Smad2 Ab9 , Smad2/3 Ab1 Smad2 Ab8 , Smad2/3 Ab1
Morpholinos smad3 MO1 smad3 MO1 smad3 MO1
ORFs smad3 ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556