Gene Symbol: rab5a Gene Name: RAB5A, member RAS oncogene family Synonyms: rab5 Add Xenopus synonyms Gene Function: small GTPase Interactants: kcne1(3) , rab11a(3) , kcnq1(2) , nodal(2) , nsf(2) , rab7a(2) , rhoa(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001008067|Xenopus (Silurana) tropicalis RAB5A, member RAS oncogene family (rab5a), mRNA CAAGAAGCTGGACGTTAACGGCGTTGCGGGACGTTTAAGCAGCGATCCGGGAGCCCGGGCTGTGTGAGGAAATCGGCTCTGTCCCGCGAAGAGCGGGCCTGTTTGGCGATTGCCAGAAGGATAAGTGAGCATCCAACCCACCCTTTGCTTATTGGGCTGCAGCCGACTTTGTAATCATCAGACGTTTTGCCTACAATCAAACATGGCAAACCGAGGCGGAGCTACCAGACCGAATGGACCGAATGCAGGAAATAAAATCTGTCAGTTTAAACTTGTCCTTTTAGGAGAATCCGCAGTTGGAAAGTCTAGTCTAGTGCTTCGCTTCGTAAAGGGACAGTTTCACGAATTCCAAGAGAGCACAATTGGAGCTGCTTTCCTTACCCAAACAGTCTGTCTCGATGATACAACTGTAAAATTTGAAATTTGGGATACAGCTGGTCAAGAGAGGTATCACAGCTTGGCCCCAATGTACTACAGGGGAGCCCAAGCTGCAATAGTTGTATATGACATTACAAATGAGGAATCATTTGCTAGAGCAAAGAACTGGGTAAAAGAGCTTCAGAGACAGGCAAGCCCCAATATTGTGATAGCTTTATCTGGTAACAAAGCTGATCTGGCCTCAAAGAGAGCTGTGGATTTTCAAGAAGCTCAAGCTTACGCAGATGACAACAGCTTATTGTTCATGGAGACTTCTGCTAAGACATCAGTGAATGTGAATGAGATATTCATGGCTATAGCTAAAAAGCTTCCCAAGACGGAACCACAGGCTGGAGGAAGCAACACCATCAGAGGAAGAGGAGTAGACCTTACTGAAACAGCACAACCTACCAAAAGTCAATGCTGTAGTAACTAACTAAAGGCTTCTTGTTCTTTAAACTGTATGGATATTATCTTGCTTCCTAATTGTTAATAACAATTTAGTGTTTAATCCTGTCTTGGCCTTGGTGCCAGCCCTTTCAGAGCAATGCATTGCAAGCCCCCATGGCAGTGAGTATGTTAAACTAGGCCCTGTGAAAACTAATAAAGGGAGACTTGCCGTGTGGTCTCATACATAATACAGAGTTATTTTACTGCTAATTCTGATTTTTTCTTTTTAACATGCATGCATTATGTTCTACAAGCTGTTCTCAGTGTGGGAGAATAGGCCGGTGTATTATACAGAGCTTTATCAGATGCAGGACCTTGGAGAGAACAATACTGGTCTCTGCAATGCATTGCAAACTTCTGGGTGCAAAGTAGAAATGGTTATATTATTACGGTGACAATTAGCCCAAAGTGGAACTTTTAAAACTTTTGTTTTTCTAAAAAAGAAAAAGAAAAAAAAAGATTTTTTTAAGCTAATACAAGCAGGGTATAAAAATCTATTCTCATCTCTCTTTACAGTGTTTGCTCAAAATCACCTTCTCCAAAATCCAGCTCTACATTCCGCTTATTAATTTATAGCTTGTTAGCCACTAATTCCTCCGCTTTCTTCAGATGAGACCGATAAACAGAATATTGTTTGATTACGCCAATAACCCACAAATGTTTAGGGGATGAGCTTAGTTTTTATTTCATAGACAAGTACCGAGAATCGTGTTTAACACTGATCAATTCTATTCAAGGTGATTAGCGTGCAAAGCCATTTTTATTATCCTTTCCAGCGCCATCTTCACAGAACACCGAACTTTTTCTTTTTTTTCTTCATTTTTTATTTTTATATCCAGTTTTACCCAATACAAAACAAAAACTGCAATGTTCTAATAATGATGTATACTCAATTTAGCTATCTTAAAATTGGATGGTAAAATTGTAATGTAAATAGGGTACTAACCATAGTCTACATTTATGTTTAATATGTTCTGTTACTTGTAAGATTTGGTTAAATTGTACAGTTAACTAAAATGATAAAAATAAAAAGCTAATGGTTTTTCCTCTAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001087066|Xenopus laevis RAB5A, member RAS oncogene family (rab5a), mRNA CAAGAAGCTGGACGGTAACGGCGTTGCGGGACGGCTAAAGCAGCGATCCGGGGCAACGAGCTGTGCTAAGAAAATCGGGACTGTCCCGCGGGAGGCGGGCCTGTTTAGCGTTTGCCAGAAGGATAAAAGAGCATCCAACCCACCCTTTGCGTCTTGGGCTGCAGCCGACTTTGCAATCATCAGACATCTTGTCCGCGCTTAAACATGGCAAACCGAGGCGGAGCTACCAGACCGAATGGACCGAATGCGGGGAATAAAATCTGCCAGTTTAAGCTTGTCCTTTTAGGAGAATCTGCAGTTGGAAAGTCCAGTTTAGTGCTTCGCTTCGTAAAGGGACAGTTTCATGAATTCCAAGAAAGCACAATCGGAGCCGCTTTCCTTACCCAGACAGTCTGTCTCGATGATACAACCGTAAAATTTGAAATTTGGGATACAGCTGGTCAAGAGAGATATCACAGCCTTGCTCCAATGTATTACAGGGGAGCCCAAGCTGCAATAGTTGTATATGACATCACAAATGAGGAATCGTTTGCTAGAGCAAAGAACTGGGTAAAAGAACTGCAGAGACAGGCAAGCCCCAATATTGTGATCGCTTTATCTGGTAACAAAGCTGATCTGTCCACAAAGAGAGCTGTGGATTTTCAAGAAGCTCAGGCTTACGCAGATGACAACAGCTTATTGTTCATGGAGACTTCTGCTAAGACATCAGTGAATGTGAATGAGATCTTCATGGCTATAGCTAAAAAGCTTCCAAAGACGGAACCACAGGCTGGAGCAAGCAACACCATCAGAGGAAGAGGAGTAGACCTAACTGAAACAGCACAACCCACCAAAAGTCAATGCTGTAGTAACTAATTAAAGGCTTCTTGTTCTATAAACTGTATGGATATTATCTTGCTTCCTAATTGTTAATAACAATTTAGTGTTTAATCCTGTCTTGGCCTTTGTGCCATCCCTTCAGAGCAATGCATTGCAATCCCCCATGGCAGTCAGTATGTTCAACTAGGCCCTGTGAAAACTAATAAAGAGAGACTTGCAGTGTGGTCTCATACATAATACAGAGTTCTTTTACTGCTAATTCAGATTTTTTAATATGCATGCATTATGTTCTACGATGCGTTCTCAGCGTGGGAGAATAGACTGGTGTATTATAAAGAGCTTTATCACATGCAGGACCTTGGTAAGAACAATAATTGTATCTGCAATGCATTGCAAACTTCTTGGTGGAAAGTAGAAATGGTTCTATTATAATGGTGACAATTAGCCCAAAGTGGAACTTTTAAAACTTTTTTTTTTTTTTCTAGAAAAAAAAAAGATTTTTTTAAGCTAATACAAGCAGGGTATAAAATCAATTTTTTCTCTACAGTGTTTGCTCAAAATCACCTTTTACAAAATCCAGATCTACATTCCGTTTATTAATTTATAACTTCGTAGCCACTAATTTTGCCGCTTTCAAACGATAAACAGAATATAGTATGATTACACCAAAAACTCATTAATGTTTAGGGGATAGGCTTAGTTTTTATTTCATATACAATTACCAATCAATTCTTCAAGGTGATTTTTATTATGCCCTCCTGCACCATCTTCACAGAACACCAAACTCTTTCAATTCTACTTCTAATTTTGGGGGGGGGGTTTCCCTTTTTTTTTATTTTTGTATCCAGTTTTACCCAATGCAAATACAAAAAAACGCAATGTTCTAACAATTATGTATCCTCCATTTAACTATCTTAAAATTGGATGGTAAAATTGTAATGTAAATAGGGTACTGAACTGTAGACTACATTTATGTTCTGTTACTTGTAAGATTTGGTTAAAACTGTACAGTTACTAAAATGCTAAAAAAATAAAAAGCTAATGGTTTTTCCTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001008068|RAB5A, member RAS oncogene family [Xenopus (Silurana) tropicalis] MANRGGATRPNGPNAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLASKRAVDFQEAQAYADDNSLLFMETSAKTSVNVNEIFMAIAKKLPKTEPQAGGSNTIRGRGVDLTETAQPTKSQCCSN	Refseq >NP_001080535|RAB5A, member RAS oncogene family [Xenopus laevis] MANRGGATRPNGPNAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLSTKRAVDFQEAQAYADDNSLLFMETSAKTSVNVNEIFMAIAKKLPKTEPQAGASNTIRGRGVDLTETAQPTKSQCCSN

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.64975 [+] Str.41762	Xl.2484
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		15 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RAB5A
mouse		MGI	Rab5a	All(1) Targeted, other(1)
zebrafish		ZFIN ZFIN	rab5aa rab5ab

Publications
First:		Sequential actions of Rab5 and Rab7 regulate endocytosis in the Xenopus oocyte. [J Cell Biol 1997]
Most recent:		Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. [Mol Cell Biol 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		GTP binding GTPase activity small monomeric GTPase activity
Biological:		intracellular protein transport protein transport small GTPase mediated signal transduction
Cellular Component:
EC:		small monomeric GTPase
KOG:		[U] GTPase Rab5/YPT51 and related small G protein superfamily GTPases

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.27303.1.S2_at [+] Str.27303.1.S1_at	Xl.2484.1.S1_at [+] Xl.8290.1.S1_at
Affymetrix 2.0			Xl2.2484.1.S1_at

Symbol legend[+]

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