Gene Symbol: runx2 Gene Name: runt-related transcription factor 2 Synonyms: ccd, aml3, ccd1, osf2, cbfa1, pea2aa, pebp2a1, pebp2a2, pebp2aa, pebp2aa1 Add Xenopus synonyms Gene Function: transcriptional regulator Interactants: kcnj1(6) , sgk1(4) , sox9(4) , col2a1(3) , bmp4(2) , cbfb(2) , fubp1(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001135116|Xenopus (Silurana) tropicalis runt-related transcription factor 2 (runx2), mRNA GGGTTTTTAAATGGTTAATCTCCGCAGGTCGCTACCAGCCGTCGAGACCGTCGCTGTCGTCTGAGGAATATTTATTGCCGGGACATACAAAAAAAAAAAAAAGCGGACGGGCGCCACTCGGCAGAGGAAGAAGGACGATGGCGTCCAACAGTCTGTTCAGCTCGGTGACACCATGTCAGCAAAACTTCTTTTGGGATCCCAGCACCAGCCGGAGGTTCAGCCCGCCCTCCAACAGCCTCCAGCCCAGCAAGATGAGCGACGTGAGCCCGGTGGGCGGCCCGCAGCAGCCCCAACAGTCCCAGCAGCCGCAGCAACAGGAGGGGGCGGCGGTCCCCCGGCTGCGGGCTCCCGATAACCGGACCATGGTGGAGATCATCGCGGATCACCCGGCCGAGCTGGTGCGGACTGACAGCCCCAACCTCCTGTGCTCAGTGCTGCCCTCCCACTGGCGCTGCAACAAGACCCTGCCGGTGGCTTTCAAGGTGGTTGCCCTAGGAGAGGTGTCGGATGGTTCTGTGGTCACGGTCATGGCTGGCAATGATGAAAATTATTCAGCGGAACCCAGAAACGCCTCTGCGGTCATGAAAAACCAAGTGGCAAGGTTTAACGATCTGAGATTTGTGGGCAGGAGTGGAAGAGGGAAGAGTTTCACGCTCACCATAACCGTTTTCACAAACCCACCGCAAGTCGCCACCTATCACAGAGCAATGAAAGTGACCGTGGATGGCCCAAGAGAACCAAGACGGCACAGACAGAAGCTTGATGACTCTAAACCTAGTTTGTTCTCTGAACGTGATTTAGGGCGCATTCCTCATCCCAGTATGAGAATGGGTGTCCCACCTCAGAGTCCACGGCCCTCACTGAACTCGAGTCCTTTTAATCCACAAGGACAGAGTCAGATTGCGGACCCAAGGCAGACACAGTCATCCCCTCCATGGTCCTATGACCAATCATATCCATCCTATCTGAGCCAGATGACATCTCCATCCATCCATTCCACAACGCCATTGTCCTCCACCCGCGGTACAGGGCTTCCTGCTATCTCCGACGTGCCCCGGCGCCTCTCAGGTGCTTCGGAACTGGGTCCATTCTCCGATCCGCGGCAGTTTACAAGTATTTCATCATTAACAGAGAGTCGGTTTTCCAACCCACGAATGCATTATCCTGCCACATTCACGTATAGTCCTCCTGTCACCACAGGGATGTCTTTAGGTATGTCTGCAACCACTCACTATCATACCTACCTACCACCCCCTTATCCAGGCTCCTCCCAGAATCAAAGTGGACCATTCCAAACCAGCAGCACTCCCTACCTTTACTACGGTACATCATCTGGATCATACCAGTTCCCCATGGTTCCCGGGGGTGACAGATCTCCATCTCGGATGCTACCACCCTGCACCACATCCAACGGGGGCACATTGCTCAACCCCAATCTGGCCAATCAGAATGATGGCGTAGATGCAGACGGAAGCCACAGCAGCTCTCCTACTGTGTTAAACTCCACTGGTCGAATGGATGAATCCGTATGGAGGCCTTACTGATGACAGAACAGCCAATAGGAAGACATTTTTCCAAATAACACAGAAGTGCCTTTTTTTAAATGAACTTTTTGGATGTCACTATTTTTAACTTTTATAGGCTTTTATAAATAAAAAAAATAATGCAAGTAAACTGATTTGGCAAAATATTTTTGCCATTATGTTTCAAATGAGATGGTTACAAGCACACATGGCCTTAAAACTCTTATTTCTTGATCATTATTTATGTCCAACTGAACCATTCCAAAGAGTTTTCATCACCAAAAATGGTTGTGGAAGCTTTAAAAAGACTTTTTTTTCCCCACGGGGGTGAGAAGAGAATCCATTCCCGA	Refseq >NM_001097786|Xenopus laevis runt-related transcription factor 2 (runx2), mRNA ATGGCGTCCAACAGTCTGTTCAGCTCAGTGACACCATGTCAGCAAAACTTCTTTTGGGATCCCAGCACCAGCCGGAGGTTCAGCCCGCCCTCCAACAGCCTCCAGCCCGGCAAGATGAGCGACGTGAGCCCGGTGGGAGTCCCGCAGCAGCCCCAGCAGTCCCAGCAGTCTCAGCAGCAGCAGGAGGGGGCGGCGGTGCCCAGGCTCAGGGCTCACGATAACCGGGCAATGGTGGAGATCATCGCGGATCACCCGGCCGAGCTCGTGCGGACTGACAGCCCCAACTTCCTGTGCTCAGTGCTGCCCTCCCACTGGCGCTGCAACAAGACCCTGCCCGTGGCTTTCAAGGTGGTTGCCCTAGGAGAAGTGGCGGATGGTTCTGTGGTCACAGTCATGGCTGGTAATGACGGAAATCATTCAGCGGAACTCAGAAACGCCTCTGCAGTCATGAAGAATCAAGTGGCAAGGTTTAACGATCTGAGATTTGTGGGCAGGAGTGGAAGAGGGAAGAGTTTTACACTCACCATAACCGTTTTCACAAACCCGCCGCAAGTCGCCACCTATCACAGAGCAATAAAAGTGACCGTGGATGGCCCAAGAGAACCAAGACGGCACAGACAGAAGCTTGATGACTCTAAACCTAGTTTGTTCCCTGAACGTGATTTAGGGCGCATTCCTCATCCCAGTATGAGAATGGGTGTCCCACCTCAGAGTCCACGGCCCTCACTGAACTCCAGTCCTTTTAATCCACAAGGACAGAGTCAGATTGCAGACCCAAGGCAGACACAGTCATCCCCTCCATGGTCCTACGACCAATCATATCCATCCTATCTGAGCCAGATGACATCTCCATCAATTCATTCCACAACCCCATTGTCCTCCACCCGCGGTACAGGGCTTCCTGCTATCTCCGATGTTCCCAGGCGCCTCTCAGGTGCTTCCGAACTGGGTCCATTTTCTGATCCGCGGCAGTTTACAAGTATTTCATCATTAACAGAAAGTCGCTTTTCGAACCCACGAATGCATTATCCTGCCACATTCACGTACAGCCCTCCCGTCACCACTGGGATGTCTTTAGGTATGTCTGCAACCACACACTATCATACCTACTTACCACCCCCTTATCCAGGCTCCTCCCAGAACCAAAGTGGACCATTCCAAACCAGTAGCACTCCCTACCTTTACTACGGTACATCATCTGGATCATACCAGTTCCCCATGGTTCCCGGGGGGGACCGCTCTCCATCTCGGATGCTACCACCCTGCACCACGTCCAACGGGGGCACATTGCTTAACCCCAATCTGACCAATCAGAATGATGGTGTGGATGCAGATGGAAGCCACAGCAGTTCTCCTACTGTGTTAAATTCCAGTGGTCGAATGGATGAATCCGTATGGAGGCCTTACTGATGACGGAAGTCAATAGGAAGACATTTTTCCAAACAATACGGAAGTGCCTTTAATTAATGAACTTTTTGGATGTCACTATTTTTAGCTTTTATAGGCTTTTAATAAATAATAAAAAAAAATATGCAACTGAACTGATTTGGCAAAATATTTTTGCCCTTTTGTTACAAATACTATGGTTACAAGCACACAAAGCCTTAAAANTTTTATTTCTTGATTACTATTTATAACCAACTTTACCATTCCAAAGGATTTTCATCACCAAAATGGTTTTGAAAGCTTTAAAAAGACTTTTTTTTTTCTCAACCACGGGGTGAAAGAAGATTCCATTTCCAAAGTGGGCGTCCAAGCCGCAACTTGCCTTATGTCCAATAAAAGGGAAGCCCTGGAATATCTGACTGATACGTGACAACAACTGAAGCCG
Protein		Refseq >NP_001128588|runt-related transcription factor 2 [Xenopus (Silurana) tropicalis] MASNSLFSSVTPCQQNFFWDPSTSRRFSPPSNSLQPSKMSDVSPVGGPQQPQQSQQPQQQEGAAVPRLRAPDNRTMVEIIADHPAELVRTDSPNLLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAEPRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAMKVTVDGPREPRRHRQKLDDSKPSLFSERDLGRIPHPSMRMGVPPQSPRPSLNSSPFNPQGQSQIADPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAISDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPRMHYPATFTYSPPVTTGMSLGMSATTHYHTYLPPPYPGSSQNQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTSNGGTLLNPNLANQNDGVDADGSHSSSPTVLNSTGRMDESVWRPY	Refseq >NP_001091255|runt-related transcription factor 2 [Xenopus laevis] MASNSLFSSVTPCQQNFFWDPSTSRRFSPPSNSLQPGKMSDVSPVGVPQQPQQSQQSQQQQEGAAVPRLRAHDNRAMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVADGSVVTVMAGNDGNHSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFPERDLGRIPHPSMRMGVPPQSPRPSLNSSPFNPQGQSQIADPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAISDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPRMHYPATFTYSPPVTTGMSLGMSATTHYHTYLPPPYPGSSQNQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTSNGGTLLNPNLTNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.34015	Xl.75100
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		5 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RUNX2	OMIM:119600
mouse		MGI	Runx2	All(9) Targeted, knock Out(3) Targeted, other(3)
zebrafish		ZFIN ZFIN	runx2b runx2a

Publications
First:		Aldosterone binding sites along nephron of Xenopus and rabbit. [Am J Physiol 1989]
Most recent:		WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathway. [Biochim Biophys Acta 2013]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		ATP binding DNA binding
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Runt and related transcription factors

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.34015.1.S1_at
Affymetrix 2.0

Symbol legend[+]

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