szl Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (66)

Nucleotides (60)

Interactants (260)

XB-GENEPAGE-482076

Gene Symbol: szl Gene Name: sizzled Synonyms: secreted frizzled, xszl, sizzled, frzb3 Add Xenopus synonyms Gene Function: CRD domain wnt inhibitor Interactants: chrd(29) , wnt8a(24) , bmp4(19) , sox2(19) , myod1(17) , otx2(17) , frzb(15) View All	1/6

XB-GENE-482077

XB-GENE-482081

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001044506\|Xenopus (Silurana) tropicalis sizzled (szl), mRNA TGCAAACATGACTGGAGTCTTCCTGCTCCTCTCCGCCTCCATGCTGGCCTGCGCCGCCGCCTTTGACATTGGATTATCCACTAAGTGCGTCTCCATTCCAAAAGAGATGGCCATGTGCAATGACATCGGCTACTCGGAGATGAGACTGCCGAACCTGATGGGACACACTAGCATGGCAGAAGTCGTGCCCAAGTCAGCAGAGTGGCAGAACCTCCTACAGACCGGCTGTCACCCATATGCCAGGATGTTCCTATGCTCCCTCTTCGCCCCAGTCTGCCTGGATACGTTCATCCAGCCCTGCCGCAGCATGTGTGTTGCTGTAAGAGACAGTTGTGCCCCAGTTCTGGCATGTCATGGGCACGCCTGGCCTGAGAGCTTAGACTGTGACAGGTTCCCAGCTGGGGAAGACATGTGCCTGGACACTCTCAGCAAAGAGTATCAGTACTCCTATAAAGAATTGCCAAAGCCAAGCTGCCAGGGCTGCCCACTAATTGAGGATTTTTTTTCACACAAGACAGTTTTGGAAGCTTTCTGTGACAATAACTTTGCTGTGAAAGTGAAATTGGCAAAGAAGAAAACAACTTCAGGAATCTATGTATATGAGACAGAAGGCCCAGTTGAGTTCATAAAACAAGGTCTGCTCCTTCCATATGACACACGTACCATGATTGAGCAGTGGCTGCTAATTAATGAGAACTGTGCTCAGAGGCTGATACGGAACAGACCCACAGTGTATGTTATTGCTGGTGACATCCATCATGGCAAGGTTTCAGTCAACAGAGTTTTCCACTGGCAGAAAAAGGACTCTCAGCTGACATTGGCTACAAGGAGGTGGAGACACCATAAATGTTGATACAACTCTTTTACTTTATTGCATGTAAATACTCAAGGCACTCTTTTAAAAAGGACACTATGTAAATATATAGTTTCTATTCATATATATATATATTGTAAAATATAAAGCCTTATTATAACAGCTGGATTGAGTGTAGCAGGTCAGCTATGTCCAAGCGCATCCCATAACCATGCTGTATAAGAAGAATATAACATTGCAGCAATTATATGAGCATTGTATAAACTGAGCAAATATTATATGTATAAAGTGAGAAAATATTAAATATTTATGTCAAGACTTTTTTGGTTTCTATTTAAGCATTTTGTCATTAAAAATATTCTAGTACAAACAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088521\|Xenopus laevis sizzled (szl), mRNA CTCGAGCATGACTGGAGTCTTCCTGCTCCTCTGCGCCTCCATGCTGGCCGCCGCCGCCTTTGACATTGGATTATCCACCAAGTGCGTTCCCATTCCCAAAGAGATGGCCATGTGCAATGACGTCGGCTACTCGGAGATGCGGTTGCCAAACCTGTTGGGACACACTAACATGGCAGAAGTCGTGCCCAAGTCAGCAGAGTGGCAGAACCTCCTACAGACCGGCTGCCACCCCTATGCCAGGACCTTCCTATGCTCCCTATTCGCCCCAGTCTGCCTGGACACGTTCATCCAGCCCTGCCGCAGCATGTGTGTTGCTGTAAGAAACAGTTGTGCTCCAGTTCTGGCATGTCATGGGCACTCCTGGCCTGAGAGCTTAGACTGTGACAGGTTCCCAGCTGGGGAAGACATGTGTCTGGACACTCTCAGCAAAGAGTATCAGTATGCCTATAAAGAACTGCCAAAGCCAAGCTGCCAGGGCTGCCCACTTATTGAAGAATTCTTTTCACACAAGACAGTCTTGGAAGCTTTTTGTGACAATAACTTTGCTGTTAAAGTGAAATTGGCAAAGAAGAAAACAACTTCAGGACTTCATGAATATGAGACCGAAGGCCCAGTTGAGTTCATTAAACAAGGTCTGCTCCTTCCATATGACACACGTACCATGATTGAACAGTGGCTGCTGATTAATGAGAATTGTGCTCAGAAGCTGATACGGAACAGACCCACAGTGTATGTTATTGCTGGTGACATCCATCATGGAAAGGTTAAAGTCAACAGGGTTTTCCACTGGCAGAAAAAGGACTCTCAGCTGACACTTGCCACAAGGAGGTGGAGACACCATAAATGTTAATACAGTTCTTGTACTTCACTGTATGTAAATACACAAGGCACTCTTTTTTAAAAGGACTATAAATATATATATATATATATATATATATATATAGTAAAACATAAAGACTTATTATAACAGCTGGATTGAGCGCATCCCATTACCATGCTGAAGAGGAAATACTATAAAATTGCAGCAATTATATGAACATTGTATAAACTGAGCAAATATTATATGTATAAAGTGAGAAAATATTAAATATTTATAACGGAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001037971\|sizzled precursor [Xenopus (Silurana) tropicalis] MTGVFLLLSASMLACAAAFDIGLSTKCVSIPKEMAMCNDIGYSEMRLPNLMGHTSMAEVVPKSAEWQNLLQTGCHPYARMFLCSLFAPVCLDTFIQPCRSMCVAVRDSCAPVLACHGHAWPESLDCDRFPAGEDMCLDTLSKEYQYSYKELPKPSCQGCPLIEDFFSHKTVLEAFCDNNFAVKVKLAKKKTTSGIYVYETEGPVEFIKQGLLLPYDTRTMIEQWLLINENCAQRLIRNRPTVYVIAGDIHHGKVSVNRVFHWQKKDSQLTLATRRWRHHKC	Refseq >NP_001081990\|sizzled precursor [Xenopus laevis] MTGVFLLLCASMLAAAAFDIGLSTKCVPIPKEMAMCNDVGYSEMRLPNLLGHTNMAEVVPKSAEWQNLLQTGCHPYARTFLCSLFAPVCLDTFIQPCRSMCVAVRNSCAPVLACHGHSWPESLDCDRFPAGEDMCLDTLSKEYQYAYKELPKPSCQGCPLIEEFFSHKTVLEAFCDNNFAVKVKLAKKKTTSGLHEYETEGPVEFIKQGLLLPYDTRTMIEQWLLINENCAQKLIRNRPTVYVIAGDIHHGKVKVNRVFHWQKKDSQLTLATRRWRHHKC

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.16161	Xl.620
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		73 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human
mouse
zebrafish		ZFIN	szl	11 Lines(s)

Publications
First:		Fritz: a secreted frizzled-related protein that inhibits Wnt activity. [Mech Dev 1997]
Most recent:		Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. [J Biol Chem 2012]
		View All Papers 24 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		transmembrane receptor activity
Biological:		multicellular organismal development
Cellular Component:		membrane
EC:
KOG:		[T] Smoothened and related G-protein-coupled receptors

Reagents		tropicalis	laevis
Clones		EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.16161.1.S1_at	Xl.620.1.S1_s_at [+] Xl.620.1.S1_at
Affymetrix 2.0			Xl2.620.1.S1_s_at [+] Xl2.620.1.S1_at

Symbol legend[+]