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XB-GENEPAGE-482491
Gene Symbol:
pitx2
Gene Name: paired like homeodomain 2
Synonyms:
pitx2-A
,
xPtx2
,
xpitx2
,
pitx2c
,
pitx2-a
,
pitx2-b
( Gene Function: homeodomain transcription factor Protein Function
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May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry. Could play a role at the interface of lateral plate signaling and heart and gut morpho...[+]
Interactants:
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Diseases: Disease Ontology:
familial atrial fibrillation
OMIM:
ANTERIOR SEGMENT DYSGENESIS 4; ASGD4
External Links:
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Xenbase Gene ID | XB-GENE-482492 | XB-GENE-482496 | XB-GENE-6253059 | |||||
Gene Symbol | pitx2 | pitx2.L | pitx2.S | Chromosome | Chr1 | chr1L | chr1S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
549981
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398033
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373586
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Embryonic Protein Expression | Stage profile:![]() |
Stage profile:![]() |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | pitx2 | pitx2.L | pitx2.S | |||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Pitx2 determines left-right asymmetry of internal organs in vertebrates., Nature 1998 |
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Most Recent |
Retinoic acid production, regulation, and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification., Development 2021 |
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All | View All Papers 23 paper(s) referencing morpholinos 13 paper(s) referencing OMIMs 25 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 30 terms | 5 terms | 6 terms | |||||
PANTHER | pitx2 | |||||||
KEGG Pathways | K04686 | K04686 | ||||||
KOG |
[K] Transcription factor PTX1, contains HOX domain
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | pitx2 | |||||||
Morpholinos (on-target & off-target) | pitx2 MO1 , pitx2 MO2 | pitx2 MO1 , pitx2 MO2 | ||||||
ORFs | pitx2.S ORF1 | |||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
Symbol legend:



