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Summary Expression Gene Literature (116) GO Terms (25) Nucleotides (126) Proteins (40) Interactants (1092) Wiki
XB-GENEPAGE-482491

Gene Symbol: pitx2

Gene Name: paired like homeodomain 2

Synonyms: pitx2-A , xPtx2 , xpitx2 , pitx2c , pitx2-a , pitx2-b ( Add Xenopus synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry. Could play a role at the interface of lateral plate signaling and heart and gut morpho...[+]

Interactants: Loading ...
Disease Ontology: iridogoniodysgenesis syndrome [+]

OMIM Diseases: ANTERIOR SEGMENT DYSGENESIS 4; ASGD4 [+]

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Xenbase Gene ID XB-GENE-482492 XB-GENE-482496 XB-GENE-6253059
Gene Symbol pitx2 pitx2.L pitx2.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL TrEMBL TrEMBL Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine pitx2 pitx2.L pitx2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PITX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Pitx2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR pitx2 ZFIN Ensembl
chicken
GEISHA PITX2 Ensembl
fruit fly
worm
WORMBASE
Publications
First Pitx2 determines left-right asymmetry of internal organs in vertebrates., Nature 1998  
Most Recent Mechanical strain, novel genes and evolutionary insights: news from the frog left-right organizer., Curr Opin Genet Dev 2019  
All View All Papers 23 paper(s) referencing morpholinos 12 paper(s) referencing OMIMs 20 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 23 terms 5 terms 4 terms
PANTHER pitx2
KEGG Pathways K04686 K04686
KOG [K] Transcription factor PTX1, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Morpholino pitx2 MO1 , pitx2 MO2 , pitx2 MO3 pitx2 MO1 , pitx2 MO2 , pitx2 MO3 pitx2 MO1 , pitx2 MO2 , pitx2 MO3
ORF pitx2.S ORF1
Affymetrix 1.0 Str.10206.2.A1_a_at [+] Xl.103.1.S1_at Xl.104.1.S1_s_at [+]
Affymetrix 2.0 Xl2.103.1.S1_s_at [+] Xl2.104.2.S1_a_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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