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Summary Expression Gene Literature (119) GO Terms (29) Nucleotides (145) Proteins (51) Interactants (1119) Wiki
XB-GENEPAGE-482491
Gene Symbol:
pitx2

Gene Name:
paired like homeodomain 2

Synonyms:
pitx2-A , xPtx2 , xpitx2 , pitx2c , pitx2-a , pitx2-b ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry. Could play a role at the interface of lateral plate signaling and heart and gut morpho...[+]


InterPro :
Peptidase M4/M1 CTD sf , Peptidase M1 dom , Peptidase M1 , M1 LTA4H [+]

Interactants:
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Diseases: 


Disease Ontology:
iridogoniodysgenesis syndrome [+]

OMIM:
ANTERIOR SEGMENT DYSGENESIS 4; ASGD4 [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-482492 XB-GENE-482496 XB-GENE-6253059
Gene Symbol pitx2 pitx2.L pitx2.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 549981
398033
373586
mRNA RefSeq RefSeq RefSeq
Protein RefSeq RefSeq RefSeq
Genomic
 tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine pitx2 pitx2.L pitx2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PITX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pitx2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pitx2 Ensembl
zebrafish
ZFIN, AGR pitx2 ZFIN Ensembl
chicken
GEISHA PITX2 Ensembl
fruit fly
worm
Publications
First Pitx2 determines left-right asymmetry of internal organs in vertebrates., Nature 1998  
Most Recent Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility., Proc Natl Acad Sci U S A 2019                                    
All View All Papers 23 paper(s) referencing morpholinos 13 paper(s) referencing OMIMs 21 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 27 terms 5 terms 4 terms
PANTHER pitx2
KEGG Pathways K04686 K04686
KOG [K] Transcription factor PTX1, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks pitx2
Morpholinos pitx2 MO1 , pitx2 MO2 , pitx2 MO3 pitx2 MO1 , pitx2 MO2 , pitx2 MO3 pitx2 MO1 , pitx2 MO2 , pitx2 MO3
ORFs pitx2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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