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Summary Expression Gene Literature (61) GO Terms (38) Nucleotides (359) Proteins (49) Interactants (641) Wiki
XB-GENEPAGE-482653
Gene Symbol:
zic2

Gene Name:
Zic family member 2

Synonyms:
Zinc finger protein of the cerebellum 2 , xzic2 , hpe5 , zic2-a , zic2-b ( Add synonyms , Nomenclature history )

Gene Function:
zinc finger, C2H2 type

Protein Function :
Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal...[+]


InterPro :
NEMO N , NEMO ZF , CC2-LZ dom , Chromo domain [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
holoprosencephaly 5

OMIM:
HOLOPROSENCEPHALY 5; HPE5

External Links:
1/6
 
Xenbase Gene ID XB-GENE-482654 XB-GENE-482658 XB-GENE-6251643
Gene Symbol zic2 zic2.L zic2.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549779
397704
379115
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine zic2 zic2.L zic2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards ZIC2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Zic2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Zic2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR zic2a zic2b ZFIN Ensembl
chicken
GEISHA ZIC2 Ensembl
fruit fly
Publications
First Gli/Zic factors pattern the neural plate by defining domains of cell differentiation., Nature 1998  
Most Recent Mcrs1 interacts with Six1 to influence early craniofacial and otic development., Dev Biol 2020                    
All View All Papers 15 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 25 terms 16 terms 16 terms
PANTHER zic2
KEGG Pathways K06235 K06235 K06235
KOG [R] FOG: Zn-finger
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks zic2
Morpholinos zic2 MO2 zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4 zic2 MO1 , zic2 MO2 , zic2 MO3
ORFs zic2.L ORF1 zic2.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info