Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (47) GO Terms (22) Nucleotides (334) Proteins (33) Interactants (310) Wiki
XB-GENEPAGE- 482653

Gene Symbol: zic2

Gene Name: Zic family member 2

Synonyms: Zinc finger protein of the cerebellum 2 , xzic2 , hpe5 , zic2-a , zic2-b
Add Xenopus synonyms , Nomenclature history

Gene Function: zinc finger, C2H2 type

Protein Function:
Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal...[+]


Interactants: YYY

OMIM Disease Associations: HOLOPROSENCEPHALY 5; HPE5
1/6
 
Xenbase Gene ID XB-GENE-482654 XB-GENE-482658 XB-GENE-6251643
Gene Symbol zic2 zic2.L zic2.S
Chromosome scaffold_2 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.1864 [+] Xl.1085 Xl.2237
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 53 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine zic2 zic2.L zic2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards ZIC2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Zic2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN zic2a zic2b ZFIN Ensembl
chicken
GEISHA ZIC2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. [Nature 1998]
Most recent: Wbp2nl has a developmental role in establishing neural and non-neural ectodermal fates. [Dev Biol 2017]
View All Papers 13 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 17 terms 17 terms
EC
PANTHER zic2
KEGG Pathways K06235 K06235 K06235
KOG [R] FOG: Zn-finger
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s) EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4 zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4 zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4
ORF zic2 ORF2 zic2 ORF1
Affymetrix 1.0 Str.24662.1.S1_a_at [+] Xl.1085.1.S1_at Xl.2237.1.S1_at [+]
Affymetrix 2.0 Xl2.1085.1.S1_at Xl2.2237.1.S1_at [+]

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556