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Summary Expression Gene Literature (58) GO Terms (34) Nucleotides (336) Proteins (37) Interactants (626) Wiki
XB-GENEPAGE-482653
Gene Symbol: zic2

Gene Name: Zic family member 2

Synonyms: Zinc finger protein of the cerebellum 2 , xzic2 , hpe5 , zic2-a , zic2-b ( Add synonyms , Nomenclature history )

Gene Function: zinc finger, C2H2 type

Protein Function :
Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal...[+]

Interactants: Loading ...
Diseases:  Disease Ontology: holoprosencephaly 5

OMIM: HOLOPROSENCEPHALY 5; HPE5

External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
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Xenbase Gene ID XB-GENE-482654 XB-GENE-482658 XB-GENE-6251643
Gene Symbol zic2 zic2.L zic2.S
Chromosome Chr02 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 549779
397704
379115
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL TrEMBL RefSeq Swiss-Prot RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine zic2 zic2.L zic2.S
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards ZIC2 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Zic2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR zic2a zic2b ZFIN Ensembl
chicken
GEISHA ZIC2 Ensembl
fruit fly
worm
WORMBASE
Publications
First Gli/Zic factors pattern the neural plate by defining domains of cell differentiation., Nature 1998  
Most Recent Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development., Dis Model Mech 2020                    
All View All Papers 15 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 21 terms 16 terms 16 terms
PANTHER zic2
KEGG Pathways K06235 K06235 K06235
KOG [R] FOG: Zn-finger
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks zic2
Morpholinos zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4 zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4 zic2 MO1 , zic2 MO2 , zic2 MO3 , zic2 MO4
ORFs zic2.L ORF1 zic2.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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