Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (178) GO Terms (19) Nucleotides (158) Proteins (49) Interactants (1877) Wiki
XB-GENEPAGE-482739

Gene Symbol: pax3

Gene Name: paired box 3

Synonyms: pax-3 , Waardenburg syndrome 1 , xpax3 , pax3-a , pax3-b , ws1 , cdhs , hup2 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: paired box transcription factor with homeodomain

Protein Function :
Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neura...[+]

Interactants: Loading ...
Disease Ontology: Waardenburg syndrome type 1 [+]

OMIM Diseases: CRANIOFACIAL-DEAFNESS-HAND SYNDROME; CDHS [+]

1/8
 
Xenbase Gene ID XB-GENE-482740 XB-GENE-6252072 XB-GENE-482744
Gene Symbol pax3 pax3.L pax3.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL TrEMBL Swiss-Prot Refseq Swiss-Prot TrEMBL TrEMBL Swiss-Prot Refseq Swiss-Prot TrEMBL TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine pax3 pax3.L pax3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PAX3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Pax3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR pax3a pax3b ZFIN Ensembl
chicken
GEISHA PAX3 Ensembl
fruit fly
worm
WORMBASE
Publications
First Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities., Development 1994  
Most Recent Peroxiredoxin5 Controls Vertebrate Ciliogenesis by Modulating Mitochondrial Reactive Oxygen Species., Antioxid Redox Signal 2019    
All View All Papers 53 paper(s) referencing morpholinos 7 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 19 terms 15 terms 15 terms
PANTHER pax3
KEGG Pathways K09381 K09381 K09381
KOG [K] Transcription factor PRD and related proteins, contain PAX and HOX domains
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s) EXRC - 1 clone(s) EXRC - 1 clone(s)
Dharmacon Dharmacon Dharmacon
Antibody Pax3 Ab1 Pax3 Ab1 Pax3 Ab1
Transgene Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP)
Morpholino pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4 pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4 pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4
ORF pax3 ORF1 pax3.L ORF1 pax3.S ORF1
Affymetrix 1.0 Str.11142.1.S1_a_at [+] Xl.15871.1.S1_at [+] Xl.25932.2.A1_s_at
Affymetrix 2.0 Xl2Affx.25.1.S1_at [+] Xl2.49495.3.S1_x_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.2


Major funding for Xenbase is provided by grant P41 HD064556