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Summary Expression Gene Literature (194) GO Terms (41) Nucleotides (193) Proteins (75) Interactants (1921) Wiki
XB-GENEPAGE-482739
Gene Symbol:
pax3

Gene Name:
paired box 3

Synonyms:
pax-3 , Waardenburg syndrome 1 , xpax3 , pax3-a , pax3-b , ws1 , cdhs , hup2 ( Add synonyms , Nomenclature history )

Gene Function:
paired box transcription factor with homeodomain

Protein Function :
Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neura...[+]


InterPro :
Kinase-like dom sf , DNA-PK dom , PI3/4 kinase cat dom , PI3/4 kinase CS [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Waardenburg syndrome type 1 [+]

OMIM:
CRANIOFACIAL-DEAFNESS-HAND SYNDROME; CDHS [+]

External Links:
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Xenbase Gene ID XB-GENE-482740 XB-GENE-6252072 XB-GENE-482744
Gene Symbol pax3 pax3.L pax3.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 448464
496377
496376
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine pax3 pax3.L pax3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PAX3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pax3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pax3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR pax3a pax3b ZFIN Ensembl
chicken
GEISHA PAX3 Ensembl
fruit fly
worm
Publications
First Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities., Development 1994  
Most Recent Using Xenopus to analyze neurocristopathies like Kabuki syndrome., Genesis 2021        
All View All Papers 53 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 10 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 39 terms 17 terms 17 terms
PANTHER pax3
KEGG Pathways K09381 K09381 K09381
KOG [K] Transcription factor PRD and related proteins, contain PAX and HOX domains
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks pax3
Mutants Xla.pax3emHorb
Antibodies Pax3 Ab1 Pax3 Ab1 Pax3 Ab1
Transgenes Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP)
Morpholinos (on-target & off-target) pax3 MO4 pax3 MO2
ORFs pax3 ORF1 pax3.L ORF1 pax3.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience EXRC Horizon Source BioScience
Plasmids Addgene Addgene

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