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Summary Expression Gene Literature (189) GO Terms (27) Nucleotides (187) Proteins (66) Interactants (1911) Wiki
XB-GENEPAGE-482739
Gene Symbol:
pax3

Gene Name:
paired box 3

Synonyms:
pax-3 , Waardenburg syndrome 1 , xpax3 , pax3-a , pax3-b , ws1 , cdhs , hup2 ( Add synonyms , Nomenclature history )

Gene Function:
paired box transcription factor with homeodomain

Protein Function :
Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neura...[+]


InterPro :
Kinase-like dom sf , DNA-PK dom , PI3/4 kinase cat dom , PI3/4 kinase CS [+]

Interactants:
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Diseases: 


Disease Ontology:
Waardenburg syndrome type 1 [+]

OMIM:
CRANIOFACIAL-DEAFNESS-HAND SYNDROME; CDHS [+]

External Links:
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Xenbase Gene ID XB-GENE-482740 XB-GENE-6252072 XB-GENE-482744
Gene Symbol pax3 pax3.L pax3.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 448464
496377
496376
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq RefSeq
Genomic
 tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine pax3 pax3.L pax3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PAX3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pax3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pax3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR pax3a pax3b ZFIN Ensembl
chicken
GEISHA PAX3 Ensembl
fruit fly
worm
Publications
First Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities., Development 1994  
Most Recent Disabled-2: a positive regulator of the early differentiation of myoblasts., Cell Tissue Res 2020                                
All View All Papers 53 paper(s) referencing morpholinos 8 paper(s) referencing OMIMs 9 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 24 terms 15 terms 15 terms
PANTHER pax3
KEGG Pathways K09381 K09381 K09381
KOG [K] Transcription factor PRD and related proteins, contain PAX and HOX domains
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks pax3
Mutants Xla.pax3emHorb
Antibodies Pax3 Ab1 Pax3 Ab1 Pax3 Ab1
Transgenes Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP) Tg(pax3:eGFP) , Tg(pax3:Katushka;cryga:Venus,GFP)
Morpholinos pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4 pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4 pax3 MO1 , pax3 MO2 , pax3 MO3 , pax3 MO4
ORFs pax3 ORF1 pax3.L ORF1 pax3.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience EXRC Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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