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Summary Expression Gene Literature (4) GO Terms (27) Nucleotides (125) Proteins (33) Interactants (568) Wiki
XB-GENEPAGE-482850
Gene Symbol:
spred1

Gene Name:
sprouty related, EVH1 domain containing 1

Synonyms:
Xtspred1 , Xspred1 ( Add synonyms , Nomenclature history )

Gene Function:
regulation of signal transduction

Protein Function :
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.


InterPro :
TPR-like helical dom sf , AIP/AIPL1 , TPR 2 , FKBP N 2 [+]

Interactants:
Loading ...

Diseases: 


OMIM:
LEGIUS SYNDROME; LGSS

External Links:
 
Xenbase Gene ID XB-GENE-482851 XB-GENE-864915 XB-GENE-17337965
Gene Symbol spred1 spred1.L spred1.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493399
100158360
108700459
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More.. NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine spred1 spred1.L spred1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SPRED1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Spred1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Spred1 Ensembl
zebrafish
ZFIN, AGR spred1 ZFIN Ensembl
chicken
GEISHA SPRED1 Ensembl
fruit fly
worm
Publications
First 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., FEBS Lett 2005  
Most Recent ERK and phosphoinositide 3-kinase temporally coordinate different modes of actin-based motility during embryonic wound healing., J Cell Sci 2013                
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 27 terms 3 terms 0 term
PANTHER spred1
KEGG Pathways K04703 K04703
KOG [T] Signal transduction protein Enabled, contains WH1 domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks spred1
Morpholinos (on-target & off-target) spred1 MO1 , spred1 MO2 spred1 MO1 , spred1 MO2
ORFs spred1 ORF1 spred1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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