smad2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (126)

Interactants (189)

XB-GENEPAGE-482929

Gene Symbol: smad2 Gene Name: SMAD family member 2 Synonyms: XSmad2, smad-2 Add Xenopus synonyms Gene Function: signal transduction, TGF-beta pathway Interactants: smad4(54) , smad4.2(53) , smad3(38) , nodal(37) , smad1(37) , foxh1(22) , t(18) View All

XB-GENE-482930

XB-GENE-864923

Molecules		tropicalis	laevis
Gene		JGI XT Genome 4.1 Ensembl
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001011168\|Xenopus (Silurana) tropicalis SMAD family member 2 (smad2), mRNA AAGGATAACAATAATATATAGAGAAAGGGGAACAGGAACCCGGTGCCCGCTGGGGCTTTGGGGGCCGAGGCGCTAAGGGCCCGTCTGTATGAGCGGGGGCTTCCTCTGCCGCCATCTTGGTTCGGGGTCGTTGTTGCGTATTTCCCCCTCCTCCCTCCTGTCCAGTTAGGCCTGACCGGGCCGGGGAGCCGCCACATCTTCAGACAAGTGGATCAGAAACTGCCCTACAGCTGCGGTAGCAGTGGCAAAACATGTCCTCCATTTTGCCATTTACCCCGCCAGTTGTGAAGCGCCTGTTAGGATGGAAGAAGTCACCAAGTGGCACCACTGGCGCGGGTGGCGGTGAGCAGAACGGACAGGAAGAAAAGTGGTGCGAAAAAGCGGTAAAAAGCTTGGTGAAAAAACTAAAGAAAACGGGACAATTAGATGAGCTTGAGAAAGCCATAACGACTCAGAACTGCAACACGAAATGCGTAACGATACCAAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACCATAGATCAGTGGGATACCACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTCTCTTGATGGTCGGCTCCAGGTGTCCCACCGCAAAGGATTGCCCCACGTTATCTACTGCCGACTGTGGCGCTGGCCAGACCTGCACAGTCATCACGAACTGAAAGCGATCGAAAATTGTGAATATGCTTTTAACCTTAAAAAAGATGAAGTGTGTGTCAATCCTTATCATTATCAAAGGGTCGAGACACCAGTCTTACCACCTGTATTAGTTCCACGGCACACAGAGATCTTGACAGAGCTGCCACCTCTTGATGACTACACGCATTCCATTCCAGAAAACACTAATTTTCCTGCAGGAATTGAACCTCAGAGCAATTATATTCCAGAAACACCACCTCCTGGATATATTAGTGAAGATGGAGAAACTAGCGATCAGCAACTTAACCAAAGCATGGACACAGGGTCACCAGCTGAGCTGTCTCCGAGTACACTTTCTCCCGTCAACCACAATCTTGATTTGCAACCAGTCACCTATTCGGAACCTGCTTTTTGGTGCTCCATAGCATACTATGAACTGAATCAGCGAGTGGGAGAAACTTTCCATGCGTCGCAACCTTCGCTTACCGTGGACGGCTTCACGGACCCCTCAAACTCTGAAAGGTTCTGTTTAGGTTTACTCTCAAATGTGAACCGAAATGCCACGGTGGAAATGACCAGGCGTCATATAGGAAGAGGAGTCCGGCTATATTACATCGGGGGCGAGGTGTTTGCAGAGTGCCTAAGTGATAGTGCTATATTTGTCCAGAGTCCAAACTGTAACCAGCGGTATGGTTGGCATCCAGCAACTGTATGTAAGATACCTCCAGGATGCAATCTGAAGATTTTTAATAACCAAGAGTTTGCTGCTCTCCTCGCTCAGTCTGTGAATCAAGGCTTCGAAGCAGTTTATCAGTTAACTCGAATGTGCACCATAAGAATGAGCTTTGTAAAAGGCTGGGGTGCTGAATACAGGCGTCAGACCGTTACAAGCACTCCATGTTGGATCGAGCTTCACCTGAACGGACCTTTGCAGTGGTTGGACAAAGTGTTGACACAGATGGGATCCCCTTCAGTGCGCTGCTCAAGCATGTCCTAATGGGCGCTTCTTTTATGTATTACCTGTGGGTGGCAACCGAAGTCCCAGCAACAGACTCAATACAGCTTGTCTGTCATAGTATTTGTGTGTGGTCCCCATGAACTGTTTACAATCCAAAAGAAAAAAAAACAAAAAACCAAAAGCGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001091495\|Xenopus laevis hypothetical protein MGC81131 (MGC81131), mRNA CTCCAGATAAGAAGCAGATCTAAATCCTATAGCAGCAGTGGCAAAACATGTCCTCGATTTTGCCATTCACCCCACCAGTTGTGAAGCGCCTGTTAGGATGGAAGAAGTCAGCAAGCGGCACCACTGGAGCAGGTGGAGGTGAGCAGAACGGTCAGGAAGAGAAGTGGTGCGAGAAAGCCGTAAAGAGTTTGGTGAAAAAACTGAAGAAAACGGGACAATTAGACGAGCTTGAGAAAGCAATAACGACACAGAACTGCAACACAAAATGCGTGACAATACCAAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACCATAGATCAGTGGGATACCACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTCTCTTGATGGTCGACTCCAGGTGTCTCACCGTAAAGGATTGCCCCACGTTATCTACAGCCGGCTGTGGCGCTGGCCAGACCTGCACAGTCATCACGAACTGAAAGCAGTCGAAAATTGTGAATATGCTTTTAACCTTAAAAAAGATGAAGTATGTGTCAATCCTTACCATTATCAGAGGGTAGAGACACCAGTTTTACCGCCGGTATTAGTTCCACGGCACACAGAAATCTTGACAGAGCTGCCACCTCTTGATGACTACACGCATTCCATTCCAGAAAACACTAATTTTCCTGCAGGAATTGAACCTCAGAGCAATTATATTCCAGAAACACCACCTCCTGGATATATTAGTGAAGATGGAGAAACTAGCGATCAGCAACTTAACCAAAGCATGGACACAGGGTCGCCAGCTGAGCTGTCTCCGAGTACGCTTTCTCCAGTCAACCACAATCTCGATTTGCAACCTGTCACCTATTCGGAACCTGCTTTTTGGTGCTCTATAGCATACTATGAACTGAATCAGCGAGTGGGAGAAACTTTCCATGCATCGCAACCGTCTCTTACCGTGGACGGCTTTACAGACCCCTCAAACTCTGAAAGGTTCTGTTTAGGTTTACTCTCAAATGTGAACCGGAATGCCACGGTGGAAATGACCAGGCGTCATATAGGAAGAGGAGTCCGGCTATATTACATCGGTGGAGAGGTGTTTGCAGAGTGCCTAAGTGATAGTGCTATTTTTGTCCAGAGTCCAAACTGTAACCAGCGGTATGGTTGGCATCCAGCAACTGTATGTAAGATACCTCCAGGATGCAATCTGAAGATTTTTAATAACCAAGAGTTTGCTGCTCTCCTCGCTCAGTCGGTGAATCAAGGCTTTGAAGCAGTTTATCAGTTAACGCGAATGTGCACCATAAGGATGAGCTTTGTAAAAGGCTGGGGTGCTGAATACAGGCGACAGACCGTTACAAGCACTCCATGCTGGATTGAGCTTCACCTGAATGGACCTTTGCAGTGGTTGGACAAAGTGTTGACACAGATGGGATCCCCTTCAGTCCGCTGCTCAAGCATGTCCTAATGGTCTCCTCTTTTATGTATTACCTGTGGGCGGCAACTGTAGTCCCAGCAACAGACTCGATTCAGTTTGTCTGTCATAGTATTTGTGTGTGGTCCCCATGAACTGTTTACAATCCAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001011168\|SMAD family member 2 [Xenopus (Silurana) tropicalis] MSSILPFTPPVVKRLLGWKKSPSGTTGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPSTLSPVNHNLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS	Refseq >NP_001084964\|SMAD family member 2 [Xenopus laevis] MSSILPFTPPVVKRLLGWKKSASGTTGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYSRLWRWPDLHSHHELKAVENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPSTLSPVNHNLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS

Genomic

tropicalis

Genome Browser

Synteny

Xenbase G-Browse

GBrowse

Expression		tropicalis	laevis
UniGene		Str.11098	Xl.60962
Gurdon EST/FL			IMAGE:6317536
Affymetrix 1.0		Str.11098.2.S1_a_at
GEO data			GEO

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tegg118f13

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene	SMAD2
mouse		MGI	Smad2	All(21) Targeted, knock Out(11) Targeted, other(9) Chemically Induced(1)
zebrafish		ZFIN	smad2

Publications
First:		Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. [Nature 1996]
Most recent:		The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo. [Mech Dev 2010]
		View All Papers 14 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		intracellular
EC:
KOG:		[TK] TGFbeta receptor signaling protein SMAD and related proteins

Suppliers		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice	geneservice
		RZPD imagenes	RZPD imagenes

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