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Summary Expression Gene Literature (622) GO Terms (33) Nucleotides (220) Proteins (60) Interactants (2174) Wiki
XB-GENEPAGE-483057
Gene Symbol:
bmp4

Gene Name:
bone morphogenetic protein 4

Synonyms:
XBMP-4 , bmp-4 , xbmp4 , zyme , bmp2b , ofc11 , bmp2b1 , DVR-4 , bmp4-a , bmp4-b ( Add synonyms , Nomenclature history )

Gene Function:
TGF-beta related peptide growth factor

Protein Function :
Posterior-ventralizing factor in Xenopus mesoderm induction. Induces posteroventral mesoderm and counteracts dorsalizing signals such as activin.


InterPro :
Collagen IV NC sf , CTDL fold , Collagen IV NC , Collagen [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
microphthalmia [+]

OMIM:
MICROPHTHALMIA, SYNDROMIC 6; MCOPS6 [+]

External Links:
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Xenbase Gene ID XB-GENE-483058 XB-GENE-483062 XB-GENE-6254046
Gene Symbol bmp4 bmp4.L bmp4.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549788
397874
399322
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine bmp4 bmp4.L bmp4.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu045c17      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards BMP4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Bmp4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Bmp4 Ensembl
zebrafish
ZFIN, AGR bmp4 ZFIN Ensembl
chicken
GEISHA BMP4 Ensembl
fruit fly
worm
Publications
First Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse., Development 1991  
Most Recent Combined transcriptomic and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells., Stem Cell Res 2020  
All View All Papers 96 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 17 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 29 terms 3 terms 8 terms
PANTHER bmp4
KEGG Pathways K04662 K04662 K04662
KOG [T] Transforming growth factor beta, bone morphogenetic protein and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks bmp4
Morpholinos (on-target & off-target) bmp4 MO3 , bmp4 MO1 , bmp4 MO2 bmp4 MO3 , bmp4 MO1 , bmp4 MO2 bmp4 MO3 , bmp4 MO1 , bmp4 MO2
ORFs bmp4.L ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info