bmp4 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (465)

Nucleotides (186)

Interactants (688)

XB-GENEPAGE-483057

Gene Symbol: bmp4 Gene Name: bone morphogenetic protein 4 Synonyms: XBMP-4, bmp-4, xbmp4, bone morphogenetic protein-4, zyme, bmp2b, ofc11, bmp2b1 Add Xenopus synonyms Gene Function: TGF-beta related peptide growth factor Interactants: chrd(124) , nog(106) , tgfb1(73) , bmp2(60) , t(56) , gsc(48) , otx2(48) View All	1/5

XB-GENE-483058

XB-GENE-483062

XB-GENE-6254046

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001017034\|Xenopus (Silurana) tropicalis bone morphogenetic protein 4 (bmp4), mRNA ATTCCAATATTCATTTTAGGAACCAGTTCCATAGTATCATCTCCATCTGCAAACTGCGTCCCGAGTCCCACTGAGCTTTTCCACAAATTTCTGTCCAAGATTGGCAGTCAAGAATCATGGACTGTTTTTCTATGCCTTGTTTTCTGTCAAGACACCATGATTCCTGGTAACCGAATGCTGATGGTCATTTTATTATGCCAAGTCCTGCTAGGAGGCACTAACCATGCCAGCCTGATACCTGAGACGGGCAAGAAGAAAGTAGTGGCCGAGATTCAGGGAGGTAGAAGGTCCGCTCAGAGCAATGAGCTCTTGCGGGATTTCGAGGTGACGCTGCTGCAGATGTTCGGCCTCCGCAAGCGGCCGCAGCCCAGTAAGGATGTGGTGGTGCCCGCGTATATGCGGGACCTGTACAGGCTTCAGTCAGCGGAGGAGGAGGATGAACTACACGATATCAGCATGGAGTACCCGGAGAGACCGACCAGCCGGGCTAACACCGTGAGGAGCTTCCATCATGAGGAGCATTTGGAGAATCTACCAAGCACAGCAGAAAATGGAAATTTCCGTTTTGTGTTCAACCTCAGCAGCATTCCAGAGAATGAGGTGATTTCTTCAGCAGAACTAAGACTCTATAGAGAACAAATAGACCATGGTCCAGCGTGGGAAGAGGGTTTCCACCGGATAAATATATATGAAGTTATGAAACCAATAACAGCAAGTGGACACATGATAAGTAGGCTGCTGGACACACGGCTAATCCACCACAATGTGACACAGTGGGAAAGTTTTGATGTAAGCCCTGCAATTATAAGGTGGACCCGGGATAAACAGATAAACCATGGGCTTGCCATTGAGGTTGTTCACCTCAACCAAACAAAAACTTATCAGGGGAAGCATGTAAGGATAAGTCGATCATTATTACCTCAAGAGGATGCAGACTGGTCACAGATGAGACCGCTTTTAATTACATTCAGCCATGATGGCAGGGGACATGCACTGACCAGGAGGTCAAAAAGAAGTCCAAAACAGCAAAGACCCCGTAAAAAAAATAAACATTGCCGGAGGCATTCTCTTTATGTGGATTTCAGCGATGTTGGCTGGAATGACTGGATTGTGGCACCTCCTGGATACCAGGCTTTTTACTGCCATGGAGATTGTCCATTTCCCTTGGCTGATCACCTAAACTCAACTAACCATGCTATTGTACAAACTCTGGTAAACTCTGTTAACTCAAGCATCCCAAAAGCGTGTTGCGTCCCCACAGATCTGAGTGCTATCTCCATGCTTTATTTGGATGAATATGACAAAGTCGTCCTTAAAAACTATCAGGAGATGGTGGTGGAAGGGTGTGGGTGCCGTTAAGTCTGAGACCCAAACAAAAGACTGTTAAGGGCTGGACTTCTTTCCACTGAACATTCACCTTGACCTTATTTATGACTTTTATGTGCAAATGTTTTGACAATATGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAAATAAAATAAGTCATTATTTTAAACATAAGCTACTTCTTTGTACAATGTGTTTATAAATGTACATTAGGATGAATATGGATTTATATGGGAATAGAGTATTTTTTCTATAAATTACCTTGTGTTAATATTTATTGGCAATATGGCTTAAAACCCCTGCCCCCCGGTAAATGAATGTAAATTAAGCTGAGGCATATTGCTGTCTGCATGTCAGTTGAATTTAAATTCCCTACTTCTGGGAATAGAACTACTTGACTTGCTAACCTGTGTGTGTGTTTATTTTTTCAAATTCATTTGCATGGAGACTCTGAAACACCTATGTTGTTATGCTAAAGTCTGTCATACCTCCCACCCTCCTGTTGTATAGCCTAAGTTCAAAGCTATGCATAGTTTTTTTTTTTTTAAAACAGAGGTTAGCAAAAGGGCTGTTAAGTAGCGAAGTACTTTGGAAAATAATTTTTCTTTAAACATCAAAGGTTACAGGATTCTTTTGAAGGTTAAAACACATTAAAAATGCACATAGACTTGACAAGTGATATGTTTAAAATTGACAGATGTTTTTATTTGTATTTTTTTACCATAAAAAAAAATCTAGAAATTTCAAATAAATCTGAT	Refseq >NM_001088032\|Xenopus laevis bone morphogenetic protein 4 (bmp4-a), mRNA ATATTCCAATATTCATTTTAGGAGCCAGTTCCTTAGTATCATCTGCAAACTGCGTCCCGAGCCCGTGCACTGAGCTTTTCCACCCATTTCTGTCCAAGATTGGCTGTCAAGAATCATGGACTGTTTTTCTATGCCTTGTTTTGTGTCAAGACATCATGATTCCTGGTAACCGAATGCTGATGGTCATTTTATTATGCCAAGTCCTGCTCGGAGGCACTAACCATGCCAGCCTCATACCTGACACGGGCAAGAAGAAAGTAGCGGCCGACATTCAGGGGGGTCGGAGGTCCGCTCAGGGCCATGAGCTCTTGCGGGATTTCGAGGTGACGCTGCTGCAGATGTTCGGCCTCGGCAAGCGGCCGCAGCCCAGTAAGGATGTGGTGGTGCCCGCGTATATGCGCGACCTGTACAGGCTTCAGTCGGCGGAGGAAGAGGATGAGCTGCACGATATCAGCATGGAGTATCCTGAGAGACCGACCAGCCGCGCCAACACTGTGAGGAGCTTCCATCACGAGGAGCATTTGGAGAATCTACCAAGCACAGCAGAAAATGGAAATTTCCGTTTTGTGTTCAACCTCAGCAGCATTCCAGAGAATGAGGTGATTTCTTCAGCAGAACTGAGACTCTATAGAGAACAAATAGACCATGGTCCAGCGTGGGATGAGGGTTTCCACCGGATAAATATATATGAAGTTATGAAACCCATAGCTGCAAATGGACTCATGATAAATAGGCTGCTGGACACGAGACTAATCCACCACAATGTGACACAGTGGGAAAGTTTTGATGTAAGCCCTGCAATTATGAGGTGGACCCGGGATAAACAGATAAACCATGGGCTTGCCATTGAGGTCATTCACCTCAACCAAACCAAAACTCATCAGGGGAAGCATGTACGGATAAGTCGATCATTATTACCTCAAGAGGATGCAGACTGGTCGCAGATGAGACCACTTTTAATTACATTCAGCCATGATGGCAGGGGACATGCACTGACCAGGAGGTCAAAAAGAAGTCCAAAACAGCAGAGACCCCGTAAAAAAAACAAACATTGCCGGAGGCATTCTCTTTATGTGGATTTCAGCGATGTGGGCTGGAATGACTGGATTGTGGCACCTCCTGGATACCAGGCCTTTTACTGCCATGGAGATTGTCCATTTCCCTTGGCTGATCACCTAAACTCAACTAACCATGCTATTGTACAAACTCTGGTAAACTCTGTTAACGCAAGCATCCCAAAAGCGTGTTGCGTCCCCACAGAACTGAGTGCTATCTCCATGCTTTATTTGGACGAATATGACAAAGTCGTCCTTAAAAACTACCAGGAGATGGTGGTGGAAGGGTGTGGGTGCCGTTGAGTCTGAGATCCAAACAATAAACTGTTAAGGGCTGGACTTCTTTCCACTGAACATTCACCTTGACCTTATTTATGACTTTTATGTGCAAAAGTTTTGACAATATGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAAAATAAAATAAGTCATTATTTT		Refseq >NM_001101793\|Xenopus laevis bone morphogenetic protein 4 (bmp4-b), mRNA GGAATTCCGGCCCCACTGAGCTTTTCCACACATTTTTTGTGTCCAACATTGGCTGTCAAGAATCATGGAATGTTTTTCTATGCCTTGTTTTCTGTCAAGACATCATGATTCCTGGTAACCGAATGCTGATGGTCATTTTATTAAGCCAAGTCCTGCTCGGAGGCACTAACTATGCCAGCCTGATACCTGACACGGGCAAGAAGAAAGTCGCGGCCGACATTCAGGGAGGAGGTCGCAGGTCGCCTCAGAGCAATGAGCTCTTGCGGGATTTCGAGGTGACGCTGCTGCAGATGTTCGGACTCCGCAAGCGGCCGCAGCCCAGTAAGGATGTGGTGGTTCCCGCTTATATGCGCGACCTGTACAGGCTTCAGTCAGCGGAGGAGGAGGATGAACTGCACGATATCAGCATGGAGTACCCCGAGACACCCACCAGCCGCGCCAACACCGTGAGGAGCTTCCATCACGAGGAACATTTGGAGAATCTACCAGGCACAGAAGAAAATGGAAATTTCCGTTTTGTGTTCAACCTCAGCAGCATTCCAGAGAATGAGGTGATTTCTTCAGCAGAACTGAGACTCTATAGAGAACAAATAGACCATGGTCCAGCGTGGGATGAGGGTTTCCACCGGATAAATATATATGAAGTTATGAAACCCATCACAGCAAACGGACACATGATAAATAGGCTGCTGGACACGAGGGTAATCCACCACAATGTGACACAGTGGGAAAGTTTTGATGTAAGCCCTGCAATTATGAGGTGGACCCTGGATAAACAGATAAACCATGGGCTTGCCATTGAGGTCATTCACCTCAACCAAACAAAAACTTATCAGGGGAAGCATGTAAGGATAAGTCGATCTTTATTACCTCAAAAGGATGCAGACTGGTCACAGATGAGACCACTTTTAATTACATTCAGCCATGATGGCAGGGGGCATGCACTGACTAGGAGGTCAAAAAGAAGTCCAAAACAGCAGAGACCCCGTAAAAAAAATAAACACTGCCGGAGACATTCTCTTTATGTGGATTTCAGCGATGTGGGCTGGAATGATTGGATTGTGGCACCTCCTGGATACCAGGCCTTTTACTGCCATGGAGATTGTCCATTTCCCTTGGCTGATCACCTAAACTCAACTAACCATGCTATTGTACAAACTCTGGTAAACTCTGTTAACTCAAGCATCCCAAAAGCATGCTGCGTCCCCACAGAACTGAGTGCTATCTCCATGCTTTATTTGGATGAATATGACAAAGTCGTCCTTAAAAACTACCAGGAGATGGTGGTGGAAGGGTGTGGGTGCCGTTGAGTCTGAGATCCAAACAAAAGACTGTTAACGGCTGGACTTCTTTCCACTGAACATTCACCTTGACCTTATTTATGACTTTTATGTGTAAATGTTTTTTTGACAATATGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAAAAAAATAAAATAAGTCATTATTTTAAACATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACGGAATTC
Protein		Refseq >NP_001017034\|bone morphogenetic protein 4 [Xenopus (Silurana) tropicalis] MIPGNRMLMVILLCQVLLGGTNHASLIPETGKKKVVAEIQGGRRSAQSNELLRDFEVTLLQMFGLRKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPERPTSRANTVRSFHHEEHLENLPSTAENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWEEGFHRINIYEVMKPITASGHMISRLLDTRLIHHNVTQWESFDVSPAIIRWTRDKQINHGLAIEVVHLNQTKTYQGKHVRISRSLLPQEDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTDLSAISMLYLDEYDKVVLKNYQEMVVEGCGCR	Refseq >NP_001081501\|bone morphogenetic protein 4 precursor [Xenopus laevis] MIPGNRMLMVILLCQVLLGGTNHASLIPDTGKKKVAADIQGGRRSAQGHELLRDFEVTLLQMFGLGKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPERPTSRANTVRSFHHEEHLENLPSTAENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWDEGFHRINIYEVMKPIAANGLMINRLLDTRLIHHNVTQWESFDVSPAIMRWTRDKQINHGLAIEVIHLNQTKTHQGKHVRISRSLLPQEDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNASIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR		Refseq >NP_001095263\|bone morphogenetic protein 4 precursor [Xenopus laevis] MIPGNRMLMVILLSQVLLGGTNYASLIPDTGKKKVAADIQGGGRRSPQSNELLRDFEVTLLQMFGLRKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPETPTSRANTVRSFHHEEHLENLPGTEENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWDEGFHRINIYEVMKPITANGHMINRLLDTRVIHHNVTQWESFDVSPAIMRWTLDKQINHGLAIEVIHLNQTKTYQGKHVRISRSLLPQKDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.490	Xl.4619		Xl.1141 [+] Xl.40611 Xl.47869
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		95 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	BMP4	OMIM:607932
mouse		MGI	Bmp4	All(16) Targeted, knock Out(3) Targeted, other(13)
zebrafish		ZFIN	bmp4	22 Lines(s)

Publications
First:		Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. [Development 1991]
Most recent:		Gene expression responses for detecting sublethal effects of xenobiotics and whole effluents on a Xenopus laevis embryo assay. [Environ Toxicol Chem 2013]
		View All Papers 64 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity
Biological:		growth
Cellular Component:
EC:
KOG:		[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 1 clone(s)	EXRC - 2 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.26831.1.S1_s_at [+] Str.490.1.S2_at StrEns.5192.1.S1_s_at			Xl.10632.1.A1_at [+] Xl.4619.1.S1_s_at
Affymetrix 2.0			Xl2.4619.1.S1_s_at [+] Xl2.4619.1.S1_x_at		Xl2.1141.1.S1_x_at [+] Xl2.40611.1.A1_at Xl2.10632.1.A1_at

Symbol legend[+]