Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (27) GO Terms (4) Nucleotides (71) Proteins (26) Interactants (598) Wiki
XB-GENEPAGE- 483145

Gene Symbol: six6

Gene Name: SIX homeobox 6

Synonyms: XOptx2 , Six6.1 , Six6.2 , xSix6 , optx2 , optic six gene 2
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor

Protein Function :


Interactants: Loading ...

Disease Ontology:
   MICROPHTHALMIA

OMIM Diseases:
   OPTIC DISC ANOMALIES WITH RETINAL AND/OR MACULAR DYSTROPHY; ODRMD [+]
 

Xenbase Gene ID XB-GENE-483146 XB-GENE-864947 XB-GENE-1021810
Gene Symbol six6 six6.L six6.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL TrEMBL Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.21495 Xl.533 Xl.21925 Xl.21533 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 29 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine six6 six6.L six6.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SIX6 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Six6 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR six6a six6b ZFIN Ensembl
chicken
GEISHA SIX6 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Giant eyes in Xenopus laevis by overexpression of XOptx2. [Cell 1999]
Most recent: Specific induction of cranial placode cells from Xenopus ectoderm by modulating the levels of BMP, Wnt and FGF signaling. [Genesis 2017]
View All Papers 8 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 4 terms 4 terms 4 terms
PANTHER six6
KEGG Pathways K19473 K19473 K19473
KOG [K] Transcription factor SIX and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
ORF six6 ORF1 six6.S ORF1
Affymetrix 1.0 Str.21495.1.S1_at Xl.533.1.S1_at Xl.21925.1.S1_at
Affymetrix 2.0 Xl2.533.1.S1_at Xl2.21925.1.S1_at [+]

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.1
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556