Gene Symbol: nodal Gene Name: nodal growth differentiation factor Synonyms: Xnr-4, Xnr4, nr4, nodal4, Nodal homolog 4 Add Xenopus synonyms Gene Function: transforming growth factor beta and bone morphogenetic protein related protein Interactants: tgfb1(93) , t(67) , nodal1(60) , cer1(54) , gsc(52) , smad2(47) , chrd(43) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002936350|PREDICTED: Xenopus (Silurana) tropicalis nodal homolog 4-A-like (LOC100497218), mRNA ATGCATCTATGCTTCTACTGTCTCATCCTCCTATTTGTACCAGGAGGAAACAGCCTGGGGTTCAACAGCTACCTGAAACACATGTCCAGCAAGCCTCAGGATCATGTCAACAGAACTAAGGCAGTGGGTTCCAAGGATTTTGCTGCTCTACCTCTGCCAAGCTACATGCTTAACCTCTATCAAAGCTTCCACCATTCAGAACTGAGCCATGGCATGGAGGCTGCTCCATCACCACCATCTAACCATCGATCTGATATTATCAGAAGCCTGGCTGCAAAAAGTTTTGACCATGGAGGAAGTTTGTGGACCCTTGTATTTGACTTCTCATCCCTCAGTCAAGATGAAGAACATCAATTTGCTGAAGTCAGGTTTGACTTTAGAGTATTTGATGGCGCAATTGTGGCCGGAATGGAGGTGATGGTAGACTTTTTTCATCAATCATCAACGTGCCAAAAAAATAGCCAAAGCTATCTGTATGTTGGCTCAATTACAGGAACCCTTCGGTCAAGGTCTTCTGAAACTTGGGTGATGCTTGAGGCCACTGACATAATACATAAATGGTTTGAAAAGGATGAAAAAGGGAAAAATAATTCTGAAGCTCATGTGAAGCAACTTGAAAAATTGGCCAGAGCTAAGAGTGCAGAACGTAGATACCAGCAACAGAATACTGAAGATCGGCAGATATTGATGATGGTGTACTCCAACATTTCAAAGAAAGAGAGGCTTTCGGGGACAGCCACACTATTACAAGATGCCGCACACTCCAAATATCTTACAGTAATGCCAGGTATTCAAACAATCAGCAACTCTAGAAGGCACAGAAGAAGTCACATCTTTAAGGAACACTTGGGTATGAAGCATGTTCCAACTGCAGGCAGCTCAAGGACTCTGTGCAGGAGAGTTGACTTCTTTGTGGATTTCAAGCAGATCGGGTGGGACTCTTGGATCATTCACCCACAGAAGTACAATGCCTATCGGTGTGAAGGTGAATGTCCAAGTCCAGTTAATGAAAGTGTGAAACCAAATAACCATGCATACATGCAGAGTTTGCTGAACTACTACGCTAAAGGAAAGGCCCCGGAAGTGTGCTGCGTTCCCATCAGGATGAGTTCTCTCAGTATGGTTTACTACGATCATGATGATATTGCATTTCAGAATCACGAAGGCATGATTGTGGAAGAGTGTGGCTGCCAGTAA	Refseq >NM_001088347|Xenopus laevis nodal homolog (nodal), mRNA GGCACGAGAATGCATCTATACTTTTACTGTCTCATCCTCCTATTTGTACCAGGAGGAAACAGCCTTGGGATCAACAGCTACCTAAAACATATGTCCAACAAACCGCAGGATCATGTCAACAGAACCAAAACAGTGGATTCCAAGGACTTGGCTGCTCTACCTCTGTCAAGCTACATGCTTAACCTCTACCAAAGCTTCCACCATTCAGAACTGAACCATGGCACGGAGGGTGCTCCATCACTACCATCAAACCATCGAGCTGATATTATTAGAAGCCTGGCTGCAAAAAGTTTTGACCATGGAGGAAGCAGGTGGACACTTGTATTTGACTTCTCATCCCTCAGTCAAGAGGAAGAACATCAACTTGCTGAAGTCAGGTTTGACTTTAGAGCATTCGAAGGTGCAATTTCGGCTGAAATGGAGGTGATGGTAGACTTTTTACATCAGTCCTCATCGTGCCAAAGTATTAGTGGATGGTGCCAAAGCTATCTGTATGTCGGCTCACTTACAGGTACACTTCGGTCAAGGTCTTCAGACACCTGGGTGACGTTTGAGGCCACCGACATCATACACAAATGGTTTGAGAGGAATGAAAAGGGAAAAAGTCGTTATGAAGATCGCGAGAAGCAGCTTAAAAAACTGCCCAGAGCTAAGAGTGCAGAACGAAGGTATCAGCAACAGAATACTGAAGATCAGCAGATAGTGATGATGGTCTACTCCAACATTTCAAAGAAAGAGAGGCTTTCGGGGACAGCCACATTATTACAAGATGCTGCACACTCCAAATATCTAGTAGTAATGCCTGGTATTCAAACAATCGCCCACACTAGAAGGCACAGAAGAAGTCACATCTTTAAGGAACATGTTATGGGTATGAAGCATGTTCCACCTGCAGACAGCTCAAGGACTCTGTGCAGGAGAGTTGACTTCTTTGTCGATTTTAAGCAGATCGGATGGGACTCTTGGATCATTCACCCAATGAAGTATAATGCCTATCGGTGCGAAGGTGAATGCCCGAGTCCAGTTAATGAAAGCGTGAAGCCAAATAACCACGCATACATGCAGAGTTTGCTGAACTACTATGTTAAAGGAAAGGCTCCTGAAGTTTGCTGTGTTCCAATCAGGATGAGTTCTCTCAGTATGGTTTACTACGATCATGACGATATTGCATTTCAGAATCATGAAGGAATGATAGTGGAAGAGTGTGGCTGCCAGTGACGATACAAAAGACATTTCCAGTTATATCAGTGTTGGATTTATGGAGGTCAAAGCCTAACACTGAACAAAATAGACACATGAATTCACCTACTGGCGTACATTGTTCTACAAGCTTCATACTTTACCAGCATCATTGTTATTCTGGAGCCCAATCAAGAACCGTTGCAGAAGATGACATCACCATTTGATTTCTATTACAATATTGTGATGGCAACTTCATGTGACATAATGCCAGTACACTGCCAGCAACACTCGAAATGGCCGGAGTGCCGACATCACTGAGGTTATTGTTGGAATCCAGGATGTCACAGGACACTTAGCTCCATAAATGACTGGCAGATGCAAAACCCCAACTTTTCCCGTGTTGAAAAATGTACTTTATTGCTATGCGGACTCATCAGAAAAAAATATTGTGCACTAATGTAAATATGTAAGAGAAAATGTAATTTATTTTTGTACCTATTGGACTTTATTTTGAAAGATAAATTAAAAAAATAATAACTTTTGACCAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002936396|PREDICTED: nodal homolog 4-A-like [Xenopus (Silurana) tropicalis] MHLCFYCLILLFVPGGNSLGFNSYLKHMSSKPQDHVNRTKAVGSKDFAALPLPSYMLNLYQSFHHSELSHGMEAAPSPPSNHRSDIIRSLAAKSFDHGGSLWTLVFDFSSLSQDEEHQFAEVRFDFRVFDGAIVAGMEVMVDFFHQSSTCQKNSQSYLYVGSITGTLRSRSSETWVMLEATDIIHKWFEKDEKGKNNSEAHVKQLEKLARAKSAERRYQQQNTEDRQILMMVYSNISKKERLSGTATLLQDAAHSKYLTVMPGIQTISNSRRHRRSHIFKEHLGMKHVPTAGSSRTLCRRVDFFVDFKQIGWDSWIIHPQKYNAYRCEGECPSPVNESVKPNNHAYMQSLLNYYAKGKAPEVCCVPIRMSSLSMVYYDHDDIAFQNHEGMIVEECGCQ	Refseq >NP_001081816|nodal homolog 4-A precursor [Xenopus laevis] MHLYFYCLILLFVPGGNSLGINSYLKHMSNKPQDHVNRTKTVDSKDLAALPLSSYMLNLYQSFHHSELNHGTEGAPSLPSNHRADIIRSLAAKSFDHGGSRWTLVFDFSSLSQEEEHQLAEVRFDFRAFEGAISAEMEVMVDFLHQSSSCQSISGWCQSYLYVGSLTGTLRSRSSDTWVTFEATDIIHKWFERNEKGKSRYEDREKQLKKLPRAKSAERRYQQQNTEDQQIVMMVYSNISKKERLSGTATLLQDAAHSKYLVVMPGIQTIAHTRRHRRSHIFKEHVMGMKHVPPADSSRTLCRRVDFFVDFKQIGWDSWIIHPMKYNAYRCEGECPSPVNESVKPNNHAYMQSLLNYYVKGKAPEVCCVPIRMSSLSMVYYDHDDIAFQNHEGMIVEECGCQ UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.378
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tgas097d22

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NODAL	OMIM:601265
mouse		MGI	Nodal	All(20) Targeted, knock Out(10) Targeted, other(8)
zebrafish		ZFIN	ndr2	49 Lines(s)

Publications
First:		Effects of ionic concentration on permeability properties of nodal membrane in myelinated nerve fibres of Xenopus laevis. Potential clamp experiments. [Acta Physiol Scand 1973]
Most recent:		BMP signal attenuates FGF pathway in anteroposterior neural patterning. [Biochem Biophys Res Commun 2013]
		View All Papers 61 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity
Biological:		growth
Cellular Component:		extracellular region
EC:
KOG:		[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Reagents		tropicalis	laevis
Clones		EXRC - 1 clone(s)	EXRC - 1 clone(s)
			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.4645.1.S1_at	Xl.378.1.S1_at
Affymetrix 2.0			Xl2.378.1.S1_at

Symbol legend[+]

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