Gene Symbol: twsg1 Gene Name: twisted gastrulation homolog 1 Synonyms: tsg, twisted gastrulation, twsg Add Xenopus synonyms Gene Function: extracellular modulator of BMP activity Interactants: chrd(20) , bmp4(14) , bmp1(11) , tll2(9) , chdh(7) , otx2(7) , szl(6) View All	1/3

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001006747|Xenopus (Silurana) tropicalis twisted gastrulation homolog 1 (twsg1), mRNA CGCCATCAAGGTCTGGGAGTGTGCACTGAGCTGCATAGCTGGGCTCCTGCTCTCAGGGAAGGAAGTGTGGGGCAGCCCAGGGCTTACAGAACTGCTGCAGCAACTTCCCATTCACAGTGCTGCTGGGACACATCGCTCTTTGGTGGCCAAGTATGAAGCCCTCTCTCCTACCCATTCCAGCAGCAGCTCTGCTCCTCTGCTCTTTATGGATTTTGCCTGTTCGTTGCTGCAATAAGGCTCTGTGTGCAAGCGATGTCAGTAAATGTTTATTACAGGAGCTGTGCCATTGTCGGCCCATGGATGGAAACTGCTCCTGCTGTAAGGAGTGTATGCTGTGCCTGGGCACACTCTGGGACGAATGCTGCGACTGCGTTAATATGTGCAACCCAAGAAACTACAGCGATACACCCCCAACCTCTAAAAGTACAGTGGAGGAGATTTATCAATCCATTCCATCCCTGTTCCGGGCTCTTACTGAGGAAGACACCCAACTTAACTGGAATATTGTAACCTTCCCTGTAGTGGAAGAGCTTTCCCATCATGAGAACCTGGTCTCCTTCCTGGAAACTGTAAACCAACCACAAGAGCAAAACGTATCAGTCGAGGTCTCTCACAGCAATGACAAAGAGCACATGTGCACAGTAGTGTACTTTAATGAGTGTATGTCAATCCATCAGTGCAAGGTTTCCTGTGAGTCCATGGGAGCCTCGAAGTACCGGTGGTTCCACAATGCTTGCTGTGAATGTGTGGGGCCCGACTGTATCGACTACGGAAGCAAAACAGTAAAGTGTGTGAACTGTATGGTCTAAGTCATATCACCATGGATCAGAGAATAATCCACTGAGTACTGCATTTTACCCCCTTTCCTGCCACTGAGGCAAGCTATTTGGGGCAAATTATACACAACACCCTCTTTGGAGTGAAAAGGGATGAAGGAAAAAAAGAATGTTAATTCTAGGACAAAACACAAGAAATATATACTAGATGGTGAAATATGTAAAAAGATAACAATTTTTGTTGAATATGTATATTTTTTTATGTTTCTATCGTTTTCAATATTTTAGATTTATTTTATATTTTGTAACTATATGATGTAAATTTGCAGGTATCGTGTTGGACATGCAGCAACATTATGCATTGTGATTTCTAAACTGCTTTTATTTTTTATAAAGCCTTTCTCTGCTATCCTACCCACTGCTTTAGGAAAAGGACAATCCATTGTCTATAATTATGTATGATGGTACTGAGTAGATTGCACCAATGCAAGGTAGCTTTGGTTCAATATAAAGGAATTTAGATTTAGCAAACTGATTTAATAGGGATTTCAAATGATTTAATAGTGATAGGGAACAGTGTTACAGAAAACTGTGGTTCTTCATCTTACCGTCTCCCTTTATTTCCCATTGTCTGTCACTGGAGAACAAACTTTAATGGTGAAATACTTGCTTTTTTAATGGCAAAGAAAAAAGAACAAATTATGCTGGATTCATAGGGGAAGGGGTGACCTAGTCAGCATTCTCTACTTTTATTTGTCATTCAGTTACTCTCTAATCATACAGTGCACAGGCTATAGTACTCATTCATTTCCATGTACTTTGGGTGTTGATATGCCTCAAGCTTGCAAGGACTGCATGCTTACACTAATCTAAATGGCATAAATCATAAAAATTGGTTCCCATCATTCTCAGCAAGGAATTTTGCATTTAAATGTGGCTAGAAATGACTATAGTATATATACAGGAAGGAACATACTAGTTACTAATGTAAATATTGGTGGTTTAATCATATTCCTGATCAGACAAAAACTAATTAACAGTAAAACAAAGAGATCTGACTGTATTATATAACATATACCACTGCTTTGTCATATATAATTATATGGTATTTTTTTTAGGAAATTAGAGTATGTCTAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090771|Xenopus laevis twisted gastrulation homolog 1 (twsg1-a), mRNA GCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCTCTTTCCATTCACAGTGTTGCTGGGACAAATCACTGTTTAGTGGCCAAGTATGAAGCCCTCTTTCCTACATATTCCAGCAGCTGCACTGCTCCTTTGCTCTTTATGGATTTTGCCCATTTATTGCTGCAATAAGGCTCTCTGTGCTAGTGATGTCAGCAAATGCCTAATACAGGAGCTGTGCCAGTGTCGGCCCACAGATGGAAACTGCTCCTGCTGTAAGGAGTGTATGCTGTGTCTGGGCACACTCTGGGACGAGTGCTGCGACTGCGTTGGTATGTGCAAACCAAGAAATTACAGTGATACACCCCCAACCTCCAAAAGTACAGTAGAGGAACTTCATGAACCCATTCCATCCCTGTTCCGGGCTCTAACTGAGGGAGACACCCAACTTAATTGGAATATTGTAACCTTTCCTGTAGTGGAGGAACTTTCCCATCATGAGAACCTGGTCTCCTTCCTGGAAAATGTGAACCAACCACAAAATGTATCAGTCCAAGTGTCTCACAGCAATGAAAAAGAGCACATGTGTACAGTGGTCTATTTTGATGACTGTATGTCAATCCATCAGTGCAAGGTTTCCTGTGAGTCCATGGGAGCGTCAAAGTACCGTTGGTTCCACAACGCTTGCTGTGAATGTGTGGGGCCGGAGTGTATTGACTACGGAAGCAAAACGGTCAAGTGCGTGAACTGTATGGTTTAAGTCATATCTCCATGGAGAAGAAATGAATCCACTCTGTACTGCATATTACTCCCTCTACTGCCACTGAGGCAAGCTATTTTTGGGCAAATTATATCCGACACTCCATTTGGAGTGAAAAGGGATGAAGGAAGAAAAAGAAGGTTCATTCTGGAACAAAACTCAATTACATATATTTACCAAATATGCAGATTTGGTGAAATATGTAAAAAAAGATAAAATTTTTGTTGAATATGTATATTTTTTTATGTTTTTATAGTTTTCAATATTTTAGATTTATATTATATTTTGTAACTAAATGATGTAAATTTGCAGGTATCATGTTTTTTTTTTAAAGACTTTCTCGTCTTTCCAACCCACTGCTATAGGAAGAGTAAAGTCCATTCTATAAATGTATATGATTGTACTGAGTAGACTGCCCCAATACAAAGTAGGATGGAATTTGGATTTGGATTGGTTCTTCACATTACTGCAATCTTCCTTTACTTCCCATTGGCCATTGCTGGAATGCAGATTGCAGTGGAGAAACACCTGCTATTTAATGGCAAATAATAAAGAACAATTGAAGCCTGATTAACAGAGGGGGTGACATGGTCAGCATTCTCTACGTGTGTGTCATTCTAAGCAAACAGTAAAAATCTGCTAATTCATTTTACTATTTCCTTGTACTTTGGGTGTCTGTATGCCTCAAACTTGGATGGTGTTTGTACTTGTGCTCATCTGAATGACATAAAACATAAATATTGGTTCCCAACATTCTCAGCAAGGTGTTGTGGAATTTAAATTTGGCTGGAAAAGTCAGTATAACTGACTATAATATATTTATATATTGGAAGGTACTCCAATATTTCCTGATGAAAATATTGGTTGTTTAATCATATACCTGATGAGAAAGAACTAACAGTAACAGTAAAACAAATAATCTGAGTCTGACTGTATTTTATAACATATACTACTGCTTTGTCACATATATATATGTGGTATTTTTTTTTTAAGGAAATTAGAATGTCTAAACAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA		Refseq >NM_001086401|Xenopus laevis twisted gastrulation homolog 1 (twsg1-b), mRNA AGGGGGGGGGGGTGAANCNCAGTAACNCTNNTGAAAAGCCCGCTCGAGCNGCCGCGAATAGTGATCACTGGGCTGCATTGCTGGGCTCCTGCTCTCAGGGAAGGACTTGCAGGGTTAAGCCCAGGATTTACACAANGGNAGCTNTGCCCATTCACAGTGGCCCTGGGACATATCACTCTTTAGTGGCCAAGTATGAAGCCCTCTTTCCTTCATATTCCAGCGGCGGCTCTGCTCCTCTGCTCTCTATGGATTTTGCCCATTCATTGCTGCAATAAGGCACTTTGTGCAAGTGATGTCAGCAAATGTCTAATACAGGAGCTGTGCCAGTGTCGGCCCACGGATGGAAACTGCTCCTGCTGCAAGGAGTGTATGCTGTGCCTGGGCACACTCTGGGACGAGTGCTGTGACTGCGTTGGTATGTGCAACCCAAGGAACTACAGCGATACGCCCCCAACCTCCAAAAGTACAGTAGAGGAACTTCATGAACCCATTCCATCCTTGTTCCGGGCTCTAACTGAGGGAGACACCCAACTTAATTGGAATATTGTAACCTTTCCTGTAGTGGAGGAACTTTCCCATCATGAGAACCTGGTCTCCTTCCTGGAAACTGTGAACCAACCACAACAGCAAAATGTATCTGTCCAGGTGTCGCACAGCAATGAAAAGGAGCACATGTGTACAGTGGTCTATTTTGATGACTGCATGTCAATCCATCAGTGTAAGGTTTCCTGCGAGTCCATGGGAGCGTCAAAGTACCGGTGGTTCCACAACGCTTGCTGCGAATGTGTGGGGCCCGAGTGTATTGACTACGGAAGCAAAACAGTCAAGTGCGTGAACTGTATGGTTTAAGTCCTATCTCCATGAAAAAGAAAAGAATTCACTCTATATTGCATTTTACCCCCTTTCATGCCACTGAGGTACGCTATTTTTGGGCAAATTATATCTCCGACACCATTTTTGGAGTGAAAAG
Protein		Refseq >NP_001006748|twisted gastrulation homolog 1 precursor [Xenopus (Silurana) tropicalis] MKPSLLPIPAAALLLCSLWILPVRCCNKALCASDVSKCLLQELCHCRPMDGNCSCCKECMLCLGTLWDECCDCVNMCNPRNYSDTPPTSKSTVEEIYQSIPSLFRALTEEDTQLNWNIVTFPVVEELSHHENLVSFLETVNQPQEQNVSVEVSHSNDKEHMCTVVYFNECMSIHQCKVSCESMGASKYRWFHNACCECVGPDCIDYGSKTVKCVNCMV	Refseq >NP_001084240|twisted gastrulation protein homolog 1-A precursor [Xenopus laevis] MKPSFLHIPAAALLLCSLWILPIYCCNKALCASDVSKCLIQELCQCRPTDGNCSCCKECMLCLGTLWDECCDCVGMCKPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVTFPVVEELSHHENLVSFLENVNQPQNVSVQVSHSNEKEHMCTVVYFDDCMSIHQCKVSCESMGASKYRWFHNACCECVGPECIDYGSKTVKCVNCMV UniProtKB		Refseq >NP_001079870|twisted gastrulation protein homolog 1-B precursor [Xenopus laevis] MKPSFLHIPAAALLLCSLWILPIHCCNKALCASDVSKCLIQELCQCRPTDGNCSCCKECMLCLGTLWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVTFPVVEELSHHENLVSFLETVNQPQQQNVSVQVSHSNEKEHMCTVVYFDDCMSIHQCKVSCESMGASKYRWFHNACCECVGPECIDYGSKTVKCVNCMV UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.1743	Xl.778		Xl.502
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		3 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	TWSG1
mouse		MGI	Twsg1	All(6) Targeted, knock Out(3) Targeted, other(3)
zebrafish		ZFIN ZFIN	twsg1a twsg1b

Publications
First:		Complement and Reactants of Acute Phase of Inflammation in the Processes of Functional Activity of Non-Specific Resistance and Immunoregulation. [Russ J Immunol 1999]
Most recent:		Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells. [Genesis 2012]
		View All Papers 7 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		protein binding
Biological:		embryonic development
Cellular Component:
EC:
KOG:

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 2 clone(s)	EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.1743.1.S1_at	Xl.778.1.S1_at		Xl.502.1.S1_at
Affymetrix 2.0			Xl2.778.1.S1_at [+] Xl2.778.2.S1_a_at		Xl2.502.1.S1_at

Symbol legend[+]

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