nlk Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (13)

Nucleotides (54)

Interactants (49)

XB-GENEPAGE-483543

Gene Symbol: nlk Gene Name: nemo-like kinase Synonyms: Xnlk, nlk1 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: nlk.2(10) , mapk1(5) , map3k7(4) , nr2c2(4) , chrd(2) , dvl2(2) , ccnb1(1) View All

XB-GENE-483544

XB-GENE-864990

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001123413\|Xenopus (Silurana) tropicalis nemo-like kinase (nlk), mRNA TCAAAGTTTTAGCGACAGCTGTGTTGTGCAAGTTGATATAGGATGACCCCTCTTTTGAGGCTGTTATAGGAGGCCTTTTGATATCCACTTTATGGCCAAGTGACAGGCTGATCATCAGTCAAGTCCATAGGAGGGCATTTCTGAATGTCTCTTTGTGGCACATCTTCCAATGCAAATATGATGGCGGCATATAATGGGGGCACATCAACAGCAGCTGGGGGGCACCACCACCATCATCACCATCACCTTGCCCATTTGCCCCCTCCCCACCTACACCATCATCATCACCTCCATCCTCAGCATCATCTGCACCCAGGCTCAGCAGCAGCTGTGCACCCTGTTCAGCAACATGTCTCCTCTTCATCAGCTTCCACTTCCTCCTCAGCTGCCGCAGCTGCTGCGGCAGCGGCGGCAGCAGCAGCAATGCTAAATCCAGGGCAGGCCCAGTCCTACTTTCCATCTCCAGCTCCAGGCCAAGCTCCAGGTCCTGCAGCAGCAGTGGCCCCTGCTCAGGTTCAGGCTGCTGCTGTAAAGGCTCACCACCATCAGCACTCTCATCATGCCCAGCAACTGGATATTGAACCTGATCGGCCCATTGGTTATGGCGCATTTGGAGTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAAAGAGTTGCTCTAAAAAAGATGCCCAACGTCTTCCAGAATCTAGTCTCTTGCAAGAGGGTCTTCCGAGAACTGAAGATGTTGTGTTTTTTTAAACATGACAACGTACTCTCAGCACTTGATATTCTCCAGCCACCTCATATTGATTATTTTGAAGAAATATATGTTGTCACAGAATTAATGCAGAGTGACCTCCATAAGATCATTGTCTCTCCTCAGCCGCTTAGTTCAGATCATGTCAAGGTTTTTTTGTATCAGATTTTAAGAGGTCTGAAGTATTTGCATTCAGCTGGCATTTTACATCGAGATATTAAACCAGGGAATCTACTTGTGAACAGCAACTGCGTTCTTAAGATCTGTGATTTTGGATTGGCAAGGGTTGAAGAACTTGATGAATCTCGGCATATGACTCAGGAAGTTGTCACTCAGTATTATCGGGCTCCAGAAATCCTCATGGGGAGTCGACATTATACCAACGCTATAGACGTCTGGTCTGTAGGATGCATTTTTGCAGAGTTACTTGGGCGAAGAATATTGTTTCAGGCTCAAAGTCCAATCCAACAGTTGGACTTAATCACTGATTTGTTGGGTACACCGTCACTAGAAGCAATGAGAACGGCTTGTGAAGGAGCCAAGGCACACATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTCCTGTACACACTGTCCAGCCAGGCAACTCACGAAGCTGTCCATCTACTCTGCAGGATGTTGGTCTTTGATCCATCTAAAAGGATATCAGCTAAAGATGCCTTGGCTCACCCATACCTGGATGAAGGCCGCTTGCGATATCACACTTGCATGTGCAAATGTTGTTTTTCAACTTCTTCTGGGAGGGTCTACACCAGTGATTTCGAGCCTATCACAAATCCAAAATTTGATGACACTTTTGAAAAGAACCTCAGTTCTGTTCGGCAGGTGAAAGAAATAATTCATCAGTTTATATTGGAACAGCAGAAAGGAAACAGAGTTCCTCTGTGCATCAATCCTCAGTCTGCTGCTTTTAAAAGCTTTATAAGTTCCACTGTTGCTCAACCCTCTGAGATGCCGCCATCTCCACTGGTTTGGGAGTGAGAGTGGAAGACTTACTACTGACGACCATTGTGTAGCTTTCCACTGGAGTCTGGGAATTGCAATTCTGGAGAGCGATTGCGCCTGTACTGTAATTTTACCAATTAAGGTTAAATCTACCAACCACTAGGTGTAAAAACGTATATCCTATTTAAGACAAAAGTGGCGTACTGGTGACTTTTTCGGCTCGGTGGTTGTACTTCTGAATGAATTTAACCCAGAATTGCTTATTTTATTAACTATATGATGTTTTAAGGCTCAGAACAAATTGCACCAAATGATGTAATAAATGGGTTTTTGTAGAGGTTGGTTCTAGGTTTTTAAATATTATTTTATTTATTTTTTTAATTAAAGCGAGGCTGTGTGCAAAGCATTTTTATACTGAGCCATTCCAAAAAAAACCCCTGAATTTTCTGTCAATAAGTGCGAACAGAAAATGTGTCTGAAGACCAATCACAAAGTACTTCCCATCATGAAGAATGACCAGGGGCTGACGACGTCTCGAGCTTGATGTCTCTTTCCTAGTGCTGCACTAGAACCATGTTGTTATTTATATGTTCTGAGACCAGAAGGCTTTTGCCGAGGAGGAGTGCATCTGTGACTAGAGGGAATGGACGTTCTTCCTTCCCAATATAAATATATAAATTATATATTCTATTTTTCTTAGAATTCTTTCTTTTTTTTCTTACCTTGAAGCCCTGGGCATGCATAATATCCATCTGTGTAAATAATTCCACTGGTCATTTGTAAAGGTCCTTTCTATGTCCCGCTGTATAGAGGTGAGCTAGCTTGCACATTTTAGATTCTAAAAAGGTTTTTGTGACCCCATCCCCCCCCCCCACCCCTTGCACTGGACAGTTGAAAAACAAGGAAAGGCGCTTGCTGCAAGCAGAACTGAGGGGGTACCCGTACCTGTGTTTGTGTAGGCGACGAGAGCGGCGCAACCAGGAAATGGCACAGCTGCAAATCCTTTACTTTCCATTTTCTTTTTGGTTTCAACACTGAGATCTCCTGTGCATATGTATATACAGACACAACTTAAGGCCTCTACCTCCTGGAGTATACAGCTCAGCTTGTTTCACTCCAAACGATTCTTTTTTAGCTTCAGTGTGCAGACTTGAAACTTGAATGTTCCTTCCAGTTTTTATATGTACGCATCACACTAGCGCAACCCAAGAAGGCAGAAGATCGCTCTCACCGTTATCAAGGAATTCCTGTGGATCCAACTTTTTTTGGTGGTATTTGTAGCGTGCTCTTAACTGCTAGACTTCTTGTCATTTATTCTAGAAGAATTTTTTTTTTTATCCTGAACAGGCTGGATTCAATAGGAGGACACTAAACAAAACCCAATTGGATTTCTTTTCTTTTCCTTCAGTTGCTCTTGTTTGTTTTAAGCTTTATTTTATGGGAAGTTTTTTTAACTTCAATGAAGTCATGTTGCTGTGAAACCGATGTGCGTTTGAATTCCAAATATCGGAGACATGGAGTCTTTTTTTCTTTTTCATCTTTTTTTTTTTCCTTATTTAGTTTTTCTGAAGCGGCTCCTTTAACAGACATCCCAGCGGAAGTGTTTCACCCCAGGTGTGAGGGAATAGCCCTGTGTCACCCGAAGGAAATGATAAGCAATGTGGAGCCCAAAGCTGGCTGAGGAAAGCAGTGGTGATTTGGGATACTTGCTGGTCACTTTGTAAAATGTAGATTTGAAGTTAAGTGGTGAAAACATTAAATGTGTCATTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001091101\|Xenopus laevis nemo-like kinase (nlk), mRNA CCCACGCGTCCGGTGGGAGGGTTTGGGAACACAGATACAGTGAAGTAAAGTTTTAGAGAGGGGCCCAACTAGTGTTGTGCTGTGCAGGTTGGCGAGGGATTGCTATAGGATGACCCCTCTTTTGAGGCTGTTATAGGAGGCCTTCTGATATTCACTTTATGGCCAAGTGACAGTTGATCATCCGTCAAGTACATTGGAGGGCATTTCTGTGAATGTCTCTTTGCGGCACATCTACCAATGCAAATATGATGGCGGCATATAATGGGGGCACATCAACAGCAGCTGGGGGTCACCACCACCATCATCATCACCATCACCTGGCCCATTTGCCCCCTCCCCACCTACACCATCATCACCACCTCCATCCACAGCATCATCTGCACCCAGGCTCAGCAGCAGCTGTACACCCTGTTCAGCAGCATGTCTCCTCTTCATCAGCTTCCTCTTCAGCTGCCGCCGCTGCTGCTGCAGCGGCTGCAGCAGCAGCAATGCTAAATCCAGGACAGGCCCAGTCGTACTTTCCATCTCCAGCTCCAGGGCAAGCTCCAGGTCCTGCAGCAGCAGTGGCCCCGGCTCAAGTGCAGGCTGCTGCAGTAAAGGCTCACCATCATCAGCACTCTCATCATGCCCAGCAACTGGATATTGAACCTGATCGTCCCATTGGTTATGGTGCATTTGGAGTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAAAGAGTTGCTCTGAAAAAGATGCCCAACGTCTTCCAGAATCTAGTCTCTTGCAAGAGGGTCTTCCGAGAATTGAAGATGTTGTGTTTTTTTAAGCATGACAACGTACTCTCAGCACTTGATATTCTCCAGCCACCTCATATTGATTATTTTGAAGAAATATATGTTGTCACGGAATTAATGCAGAGTGACCTTCATAAGATCATTGTCTCTCCTCAGCCTCTCAGTTCAGATCATGTCAAGGTTTTTTTGTATCAGATTTTAAGAGGTCTGAAGTATTTGCATTCAGCTGGCATTTTACATCGAGATATTAAACCAGGGAATCTACTTGTGAACAGCAACTGCGTTCTTAAGATCTGTGATTTTGGATTGGCAAGGGTTGAAGAACTCGATGAATCTCGGCATATGACTCAGGAAGTTGTCACTCAGTATTATCGGGCTCCAGAAATCCTCATGGGGAGTCGACATTATACCAACGCTATAGACATCTGGTCTGTAGGGTGCATTTTTGCAGAGTTACTCGGGCGAAGAATATTGTTTCAAGCTCAAAGTCCAATCCAACAGTTGGACTTAATCACTGATTTGTTGGGTACACCGTCACTAGAAGCAATGAGAACGGCTTGTGAAGGAGCCAAGGCACACATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTCCTCTACACACTGTCCAGCCAGGCAACTCATGAAGCTGTCCATCTGCTCTGCAGGATGCTGGTCTTTGATCCATCCAAACGGATATCGGCTAAAGATGCCTTGGCTCACCCGTACCTGGATGAAGGCCGCTTGCGATATCACACTTGCATGTGCAAATGTTGTTTTTCAACTTCTTCCGGGAGGGTCTACACCAGTGATTTTGAGCCGATCACAAATCCAAAATTTGATGACACTTTTGAAAAGAACCTCAGTTCTGTTCGGCAGGTGAAAGAAATAATTCATCAGTTTATATTGGAACAGCAGAAAGGAAACAGAGTACCTCTGTGCATCAATCCTCAGTCTGCTGCTTTTAAAAGCTTTATAAGTTCCACTGTTGCTCAACCCTCCGAGATGCCACCATCTCCACTGGTTTGGGAGTGAGAGTGGAAGACTTACTACTGACGACCATTGTGTAGCTTTCCACTGGAGTCTGGGAATTGCAATTCTGGAGAGTGATTGCACCTGTACTGTAATTTTACAAATTAAGGTTAAATCTACCAACCACTATGTGAGAAAAAAAAAGTGTATCATATTTAAGACAAAAGTGGTGTACAGCTGTGCCGTCGGTGGTTGTACTTCTGAATGGATTGAACCCAGAATTGCTTATTTTATCAAATATATGATGTTTTAAGGCTCAGAACAAATTGCACCAAATGATGTAATAAATGGGTTTTTGTAGAGGTTGGTTCTAGGTTTTTAAATATTATTTTATTTATTTTTTTAATTAAAGTGTGGCTGTGTGCAAAGCATTTTTATACTGAGCCATTCCAAAATAAACTCCCCCCCCCCCCTTAAATTTTCTGTTAATCCAAGCAACGAGTAAGGACTGGAGAATGTGTCTGGAGACCAATCACAAAGTACTTCCCATATTGAAGAATGACCAGGGGCTGACTATGTCCTGAGCTTGATGTCCCTTACCTAGTGCTGCACTAGAAACCATCTTGTTATTTATATGTTCGGAGACCAGAAGGCTTTTGGCGAGGAGGAGGAGGAGTACATCGGTGACTAGAGGGAATGGACGTTCTCCCTTCCCAATATAAATATATAAATGATATATTCTATTTTTCTTAGACTTCTTTTTTTTCTTACCTTGAAGTCCTGGGCATGCATCGTTTCCATCTGTGTATATAATTCCATTGATCATCGGTCGTTTGTAAAGGTCCTTTTTAATGTCCCACTGTATAAAGGTGAGCTAGCTTGCACATTTTAGATTATAAAAAGGTTTTTGTGACCCCCCCCCTCCCAGACCCCTCCAGCCTTTGCACTGGACAGCCTAGAAGCAAGGAAAGGTGCCAACGCTGAGAACTGAGGGAATACCTGTACCTGCGCTTGTGTAGGCGAGCAGACATGGAAACATCACGGCTAAAGAATCTTTTACTTTTCATTTGCTTTTTTGATTCAACACTGAATTCTCCTGTGCATATGTACATACAGACACAACGTAAGGCCTCTACCTCCTGGAGTAGACAGCTCAGCTCGTTTCACTCCAAATGATTATTTTTTAGCTTCAGTGTGCAGACTTGAAACTTGAATGTTCCTTCCAGTTTTTATATGTAAGCATATTCCACTAGCGCAACACGAGAAGGCAGAAGATCACTCTCACTGTTATCAAGGAATTACTACAGATGTAGTGTGCTATTACCTGCTAAACTTATTGTCATTTATCCTACAAGAATATTTTTTTGATCCTGAACAAGCTGGATTTGATAGGAGGACACTAAATAGATTTTTTTTTCTCCCTACAGTTTTTTGTTTTGTTTTAAGCTTTATTTTACGGAAATAATAATTTTTTTTTCAACTTCAATGGAGTCATTTTTGCTGTGAAAAATGTGCGTTTGAATTCCAACTATCGGAGATATGGAGTCTTTCTTTCATCTTTTTTTTTTGTTTCCTTATTTAGTTTCCTTTTTTCTGCAGCGGCTCCTTTAACAGATGCCCCGGAGGAAGTGTTTCACCTGGGGCGTAAGCAAATAGCCCGGGGTCACCAGAAGGAGATGATCAGCATTGTGGAGCACAAGGCTGGCTGAGGAAAGGTGAAACATGACCATGGTGATTTGAGATACTTGCTGGTCACTTTGTAAAATGTAGATTTGAAGTTCAGTGGTGAAAACATTAAATGTGTCATTTAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001116885\|nemo like kinase [Xenopus (Silurana) tropicalis] MSLCGTSSNANMMAAYNGGTSTAAGGHHHHHHHHLAHLPPPHLHHHHHLHPQHHLHPGSAAAVHPVQQHVSSSSASTSSSAAAAAAAAAAAAAMLNPGQAQSYFPSPAPGQAPGPAAAVAPAQVQAAAVKAHHHQHSHHAQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSGRVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE	Refseq >NP_001084570\|nemo-like kinase [Xenopus laevis] MSLCGTSTNANMMAAYNGGTSTAAGGHHHHHHHHHLAHLPPPHLHHHHHLHPQHHLHPGSAAAVHPVQQHVSSSSASSSAAAAAAAAAAAAAMLNPGQAQSYFPSPAPGQAPGPAAAVAPAQVQAAAVKAHHHQHSHHAQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSGRVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.3307	Xl.46708
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NLK
mouse		MGI	Nlk	All(5) Targeted, other(4) Gene Trapped(1)
zebrafish		ZFIN	nlk1

Publications
First:		The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. [Nature 1999]
Most recent:		Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. [EMBO J 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Mitogen-activated protein kinase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.38324.1.S1_at [+] Str.38324.1.S1_s_at Str.38324.2.A1_at Str.3307.1.A1_at
Affymetrix 2.0			Xl2.46708.1.S1_at

Symbol legend[+]