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Summary Expression Gene Literature (78) GO Terms (22) Nucleotides (71) Proteins (26) Interactants (980) Wiki
XB-GENEPAGE- 483692

Gene Symbol: pax8

Gene Name: paired box 8

Synonyms: XPax8 , XPax-8 , pax-8
Add Xenopus synonyms , Nomenclature history


Gene Function: paired box transcription factor

Protein Function :
Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 to establish the pronephric primordium in late gastrulae/early neurulae.


Interactants: Loading ...

Disease Ontology Associations: CONGENITAL NONGOITROUS HYPOTHRYOIDISM 2

OMIM Disease Associations: PAIRED BOX GENE 8; PAX8 [+]
1/11
 
Xenbase Gene ID XB-GENE-483693 XB-GENE-865008 XB-GENE-17334490
Gene Symbol pax8 pax8.L pax8.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.51436 Xl.2754
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 174 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine pax8 pax8.L pax8.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PAX8 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Pax8 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR pax8 ZFIN Ensembl
chicken
fruit fly
worm
WORMBASE
Publications
First: Molecular regulation of pronephric development. [Curr Top Dev Biol 1999]
Most recent: Anosmin-1 is essential for neural crest and cranial placodes formation in Xenopus. [Biochem Biophys Res Commun 2018]
View All Papers 32 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontologies
Functional Ontologies tropicalis laevis.L laevis.S
GO 20 terms 19 terms 0 term
PANTHER pax8
KEGG Pathways K09293 K09293
KOG [K] Transcription factor PAX2/5/8, contains PAX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s) EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Pax8 Ab1 Pax8 Ab1
Morpholino pax8 MO1 , pax8 MO2 , pax8 MO3 pax8 MO1 , pax8 MO2 , pax8 MO3 pax8 MO1 , pax8 MO2 , pax8 MO3
Affymetrix 1.0 Str.51436.2.S1_s_at [+] Xl.2754.1.S1_at
Affymetrix 2.0 Xl2.2754.1.S1_at [+]

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556