Please note upcoming maintenance times for Xenbase - times are EST:

Wednesday 12-Dec-2018 before noon: BLAST, FTP (Xenbase will be partially functional)
Thursday 13-Dec-2018 before noon: Wiki, GBrowse, JBrowse (Xenbase will be partially functional)
Friday 14-Dec-2018 starting at 5 pm through weekend: Xenbase site and database (Xenbase will be completely down)

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (48) GO Terms (13) Nucleotides (290) Proteins (30) Interactants (195) Wiki
XB-GENEPAGE-483949

Gene Symbol: tacc3

Gene Name: transforming acidic coiled-coil containing protein 3

Synonyms: maskin , xmaskin , eric1 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: Projectin/twitchin and related proteins

Protein Function :
Maternal RNA in oocytes remains in a dormant state as masking outcompetes eif4g to bind eif4e, thereby preventing translation. During oocyte maturation this complex dissolves and eif4g binds eif4e to a...[+]

Interactants: Loading ...
Disease Ontology: URINARY BLADDER CANCER

OMIM Diseases: BLADDER CANCER
 
Xenbase Gene ID XB-GENE-483950 XB-GENE-17343957 XB-GENE-865032
Gene Symbol tacc3 tacc3.L tacc3.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL TrEMBL Refseq TrEMBL TrEMBL Refseq Swiss-Prot TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images                   Ensembl In situ: Single cell: RNA-Seq:  
Data Mining tropicalis laevis.L laevis.S
XenMine tacc3 tacc3.L tacc3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards TACC3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Tacc3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR tacc3 ZFIN Ensembl
chicken
GEISHA TACC3 Ensembl
fruit fly
worm
WORMBASE
Publications
First Maskin is a CPEB-associated factor that transiently interacts with elF-4E., Mol Cell 1999  
Most recent The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development., Neural Dev 2017          
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 5 terms 0 term 9 terms
PANTHER tacc3
KEGG Pathways K14283 K14283
KOG [Z] Projectin/twitchin and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Antibody Tacc3 Ab1 , Tacc3 Ab2 Tacc3 Ab1 , Tacc3 Ab2
Morpholino tacc3 MO1 , tacc3 MO2 tacc3 MO1 , tacc3 MO2 tacc3 MO1 , tacc3 MO2
ORF tacc3.S ORF1
Affymetrix 1.0 Str.5836.1.S1_a_at Xl.580.1.S1_at
Affymetrix 2.0 Xl2.580.1.S1_a_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.10.0


Major funding for Xenbase is provided by grant P41 HD064556