pax6 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (164)

Nucleotides (123)

Interactants (477)

XB-GENEPAGE-484087

Gene Symbol: pax6 Gene Name: paired box 6 Synonyms: XLPAX6, xpax6, pax-6, an2, mgda, wagr Add Xenopus synonyms Gene Function: paired box transcription factor with homeodomain, involved in eye development Interactants: otx2(50) , rax(39) , pax2(24) , sox2(22) , sox3(19) , en2(17) , six3(17) View All	1/4

XB-GENE-484088

XB-GENE-865046

XB-GENE-6464331

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001006762\|Xenopus (Silurana) tropicalis paired box 6 (pax6), mRNA GGTGTGTGCACTGTGTAGCCGGGCTCTCTCCACTCCCATACACTCTGCTGCTCCCCCACTGACAGCCCATCTTATTGTCAGTCTCTGTCTCCTTCCCAGGATCCAGACACCCAGCCTCCCTGGGAGAAACTGCCATTTCTTTGCCTTTTCTGCCCACTGGAAGGGAAGGGGGGAATCAGCTCTGCAGATCAGACTCTCCCCCGGCAGCTGCACAGAGGATCTAGCGAAGAAGGGATGCACCAAGTAGTCCTAGGGGGAAATCACTAGGCGCACATCGACAGATGCTGGGAATTACACAGGCCCTTGGAAGAGAAGCAGAAAAGCTATCCAGAATCCCATCCATAAACCACGTGGGACCCGGCGGCGACTCAGAGATGCAGAACAGTCACAGCGGAGTCAATCAACTCGGGGGAGTGTTTGTGAACGGCCGACCCCTGCCCGACTCCACCAGGCAGAAGATCGTGGAACTGGCGCACAGCGGCGCACGTCCCTGCGACATTTCTCGGATTCTGCAGGTGTCCAACGGCTGTGTGAGTAAGATCTTAGGGAGATATTACGAGACTGGATCGATCCGACCCAGAGCAATCGGTGGCAGCAAACCCAGAGTAGCCACCCCAGAAGTGGTTAGCAAGATAGCCCAGTATAAAAGAGAGTGCCCTTCCATCTTTGCATGGGAAATCCGAGACAGGTTGCTATCTGAGGGAGTCTGTACCAACGACAATATCCCCAGTGTGTCATCAATAAACCGAGTGCTGCGCAACCTGGCGAGCGAAAAGCAACAGATGGGCGCCGATGGCATGTACGACAAGCTCAGGATGCTGAATGGGCAAACTGGGACCTGGGGGACCCGGCCAGGGTGGTACCCCGGCACCTCGGTACCTGGCCAGCCAGCACAGGACGGGTGTCAGCCGCAAGAAGGAGGAGGAGGAGGAGAAAACACAAACTCAATCAGCTCCAATGGCGAAGACTCAGACGAGGCCCAAATGAGGCTTCAGCTGAAGAGAAAATTACAAAGGAACAGAACATCTTTTACCCAGGAACAAATAGAGGCCCTAGAAAAAGAATTTGAACGAACACATTACCCCGACGTGTTTGCCAGGGAAAGATTAGCTGCCAAAATCGACCTGCCAGAAGCAAGAATACAGGTATGGTTCTCCAACAGAAGAGCAAAATGGAGAAGGGAGGAAAAACTTCGAAACCAGAGAAGGCAGGCCAGTAACACACCCAGCCACATTCCCATTAGCAGTAGTTTCAGTACGAGCGTCTACCAGCCAATCCCACAGCCTACCACACCAGTGTCCTCTTTCACATCGGGTTCCATGCTGGGCAGAACGGACACAGCATTGACAAACTCCTACAGTGCGCTGCCACCTATGCCTAGTTTTACAATGGGCAACAACCTACCTATGCAACCCCCTGTACCCAGCCAGACATCCTCCTACTCATGCATGCTGCCCACAAGTCCATCTGTGAATGGGCGGAGCTATGACACATACACACCTCCCCACATGCAGACACATATGAACAGCCAGCCAATGGGCACATCTGGCACCGCCTCTACAGGTCTCATTTCCCCTGGAGTGTCAGTCCCAGTTCAAGTACCCGGCAGTGAACCTGACATGTCTCAGTACTGGCCAAGACTACAGTAAAAACCGTGTTAATTTAACCAATGACTTTATGGAAAACAGTTGGATGTTCAGCAGTATTTTATAAAGACGGACAGACTGGCAAACAAAGGACTTGTTCACGCCGATGTGCGTCAGATACGTGGACTGTTGGAAGGACTGCATCATGGACTTTTTGCACATGGAAGGCGTTATATCAGTTGGAACAAATCTTCATTTTGATATCCAAACTTTTATCCATTTGATGTACTATTTGTAAATTGACATTTGTATGTTATGATGAATAGAACAACGCGGACTGCATAGATGGATCTACCCCCCCATTGGTCATGAAACAGAATTTTTTTTCCAATAAGGAACCCATGATCAAGCCAAGAATTAAAAGAGATAGCCAAGAGATATCAATTCCTTCTACAATTTTTTCGGTACATGGATCAACGTTCCATGTTTGTATCAACCCCTTTGGTCGGGACCTTTAACCACCACCCCTCCTAAATCTTTCCTTGGTACCCCCCGCCCCCAAAAAAGTCGACCCTACTTTACAAAAACATTAAAATAAGACAAAGAAGAAAACCACGAAGAGAGACGTTTGGTAGATGAAAGGTAGATTGTGTCTTCGATATAATCCAATTTGTTTTATGTCGAGAAATGTATGTTTTTGTCTTCCCTAGAAATCTCCCAGAACGATTTCTATAATAAAGTTCATTTCATTTTTATCTGAAAAAAAAAAAAAAAA	Refseq >NM_001085944\|Xenopus laevis paired box 6 (pax6-a), mRNA GTGGGTTTGAAAGGCAAGGCCATTCTCAGCCTCAATTCCCGCTCTGGGGAAGGAGCAGGGAGGAAGTGTTTTTTTTTTTTTTGCAGGGGGATGATGACAGGGGTCAGCCTCTGCTAATGGGCCAGTAAAGAAGATTGGAGGCAGGCACAGGGACACACACACATTAATACAGTTGAACCATCACCAATCAGCCTAGGATTCCAGCTCATCCTCCCTGGGAGAGAAAAACTGCAATTTCTTTTTTTTTTTTTTTTTTTATTCCCTTTTCTGCCTACTGCAAGGAGAAGCAGCTCTTCAGATCCTACTTGGCAGTTGCACACAGGATCTTAGCGAGGAAGGGATGATCTAAGCAGTCCTAGGGGGAAATCACTAGGCGTTGATCATCAGATGTTGGGAATTACACAGTCCCTTGGAGGAGAAACAGAAAAGATATCCAGAATTCCATACATAGACCACGTGGGATCCGGCAGCGACTTAGACATGCAGAACAGTCACAGCGGAGTAAATCAACTCGGGGGAGTGTTTGTCAACGGCCGACCCCTGCCCGACTCGACCAGACAGAAGATCGTGGAACTGGCGCACAGTGGCGCGCGACCCTGCGACATTTCTCGGATTCTGCAGGTGTCCAACGGCTGCGTCAGTAAGATCTTAGGCAGATATTACGAGACCGGATCGATCCGACCTCGGGCGATCGGTGGCAGCAAACCCAGAGTAGCCACCCCAGAAGTGGTTAACAAGATAGCCCAGTATAAGAGAGAGTGCCCTTCTATCTTTGCATGGGAAATCCGAGACAGGTTGCTTTCTGACGGAGTCTGTACCAACGACAATATCCCCAGTGTGTCATCAATAAACCGAGTGCTGCGCAACCTGGCGAGCGAGAAGCAGCAGATGGGCTCGGATGGGATGTACGACAAGCTTAGGATGCTTAACGGACAAACTGGCACTTGGGGGGCACGGCCAGGGTGGTACCCGGGCACCTCAGTACCTGGCCAACCAGCACAGGAAGGGTGTCAGCCACAAGAAGGAGGAGCAGAAAACACAAACTCAATTAGCTCCAATGGTGAAGACTCAGACGAGGCCCAGATGAGGCTTCAGCTGAAGAGAAAATTACAAAGAAACAGGACATCTTTTACCCAGGAACAAATAGAGGCGCTAGAAAAAGAATTTGAACGGACACATTATCCCGACGTGTTTGCCAGGGAAAGATTAGCTGCCAAAATCGACTTACCAGAAGCAAGAATACAGGTTTGGTTCTCCAACAGAAGAGCAAAGTGGAGAAGGGAGGAAAAACTTCGGAACCAGAGAAGGCAGGCCAGTAACACACCCAGCCACATTCCTATTAGCAGTAGTTTCAGTACGAGTGTCTACCAGCCAATCCCACAGCCTACCACACCAGTGTCCTCATTCACATCGGGTTCCATGCTGGGCAGAACGGACACAGCATTGTCAAACTCTTACAGTGCTCTGCCACCTATGCCTAGTTTTACAATGGGCAACAATCTACCTATGCAACCCCCTGTACCCAGCCAGCCATCCTCCTACTCATGCATGCTGCCCACAAGTCCATCTGTGAATGGGCGGAGCTATGACACATACACACCTCCCCACATGCAGACACATATGAACAGCCAGCCAATGGGCACATCTGGCACCACCTCTACAGGTCTCATTTCCCCTGGAGTGTCAGTCCCAGTTCAAGTACCCGGCAGTGAACCTGACATGTCTCAGTACTGGCCAAGACTACAGTAAAAACCGTGTTAATTTAACCAATGACTTTATGGAAAACAGTTGGATGTTCAGCAGTATTTTATAAAGACGGGGAGACTGAGGAAAGGACTTGTGCCAAACAGATGTGCGTAAGATACATGGGCTGTTGGAAGGAACTGCATCATGGACTTTTTGCACACAGAAGGCGTTATATCAGTTGGAACAAATCTTCATTTTGATATCCAAACTTTTATCCATTTGATGTACTATTTGTAAATTGACATTTGTATGTTATGATGACTAGAACAATGCGGACTGTATAGATGGATCTACCCCCCATTGGTCATGAAACAGATTTTTTTTTTTACAAAGGAACCCATGATCAAGCCAAGAATCTAAGAGTTTTATCAAGAGATATCAACTCCTTCTACAATTGTTTTTTTTTTGGCACATGGATCAATGTTCCATGTTTGTATCGAACTCCTTCGCCCAGGACCCCCTAACCACCGGCCCCATCTAAAATCGTCCCTTGGTATCCCACAAAAAAAAAAAAAAAA		Refseq >NM_001172195\|Xenopus laevis paired box 6 (pax6-b), mRNA GCAGTCTCTGCTAATGGGCCAGTGAAGAAGATTGGAGGCAGGCACAGGAGCAGGCACAGGAGCAGGCACAGTTGAAGCATCACCAATCAGACTAGGATTCCAGCTCATCCTCCCTGGGAGAGAGAGAGAGAAAAAAACTGCAATTTTCTTTTTTTTTTTTACTCCTTTTCTACAAGAGCCTACTTCCAACTGGCAGTTGCTCACAGGATCTGAGCGAGGAAGGGATGCTCCATTTGCAGTCCTAGGGGAAAATCACTAGGCGTTGATCAGCAGATGTTGGGAATTACACAGTCCCTGGGAGGAGAAGCAGAAAAGATATTCAGAATTCCATCCATAAACCACGTGGGACCCGGCAGCGACTCAGACATGCAGAACAGTCACAGCGGAGTAAATCAACTCGGGGGAGTGTTTGTCAACGGCCGACCCCTGCCAGATTCGACCCGACAGAAGATTGTGGAATTAGCGCACAGCGGCGCGCGACCCTGCGACATTTCTCGGATTCTGCAGGTGTCCAACGGCTGCGTGAGTAAGATCTTGGGCAGATATTACGAGACCGGATCGATCCGACCTCGGGCGATCGGTGGCAGCAAACCCAGAGTTGCCACCCCAGAAGTGGTGAACAAGATTGCCCACTATAAGCGAGAGTGCCCTTCTATCTTTGCCTGGGAAATCCGAGACAGGTTGCTGTCTGAGGGAGTCTGTACCAACGACAATATCCCCAGTGTGTCATCAATAAACCGAGTGCTGCGCAACCTGGCGAGCGATAAGCAACAGATGGGATCTGAAGGGATGTATGACAAGCTCAGGATGCTCAATGGACAAACTGCAACTTGGGGGTCGCGGCCAGGGTGGTACCCAGGCACCTCAGTACCTGGCCAACCAGCACAGGAGGGGTGTCAGCCACAAGAAGGAGTAGGAGAAAACACAAACTCAATCAGCTCCAATGGTGAAGACTCGGACGAGGCCCAAATGAGGCTTCAACTGAAGAGAAAATTACAAAGAAACAGAACATCTTTTACCCAGGAACAAATAGAGGCACTAGAAAAAGAATTTGAACGAACACATTATCCCGATGTGTTTGCCCGGGAAAGATTGGCTGCCAAAATCGACTTACCAGAAGCAAGAATACAGGTATGGTTCTCCAACAGAAGAGCAAAGTGGAGAAGGGAGGAAAAACTACGGAACCAGAGACGGCAGGCCAGTAACACACCCAGCCACATTCCCATTAGCAGTAGTTTCAGTACGAGTGTCTACCAGCCAATCCCACAGCCTACCACACCAGTGTCCTCATTCACATCGGGTGCCATGCTGGGAAGGACGGACACAGCATTGACAAACTCTTACAGTGCTTTGCCACCTATGCCTAGTTTTACGATGGGCAACAATCTACCTATGCAAGTCTCATTTCCCCTGGAGTGTCAGTCCCAGTTCAAGTACCCGGCAGTGAACCTGACATGTCTCAGTACTGGCCAAGATTACAGTAAAAACCGTGTTAATTTAACCAATGACTTTATGGAAAACAGTTGGATGTTCAGCAGTATTTTATAAAGACTGACAAACTGGGGAAAGGACTTGTGCACAGCAGACGTGAGATACGTGGACTGTTGGAAGGACTGCATCATGGACTTTTTGCACACGGAAGGCGTTGTATCAGTTGGAACAAATCTTCATTTTGATATCCAAACTTTTATCCATTTGATGTACTATTTGTAAATTGACATTTGTATGTAATGATGAATAGAACAACGCGGACTGCATAGATGGATCTACCCCCATTGGCCATGAAACTGATTTTTGTTTAACAAGGAACCCATGATCAAGCCAAGAATCTAAGAGTTTTATCAAGAGATATCAACTCATTCTACCAATTTTTTTGTTTTTTTTGATACATGGATCAATGTTCCATGTATCGTTTGGCCGGGAGCCTTAACCACCGGCCCCACCTAAAATCATTCCTTCGTATCCCACAAAAAAAAAAAA
Protein		Refseq >NP_001006763\|paired box 6 [Xenopus (Silurana) tropicalis] MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGTWGTRPGWYPGTSVPGQPAQDGCQPQEGGGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNSYSALPPMPSFTMGNNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTASTGLISPGVSVPVQVPGSEPDMSQYWPRLQ	Refseq >NP_001079413\|paired box 6 [Xenopus laevis] MLGITQSLGGETEKISRIPYIDHVGSGSDLDMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVNKIAQYKRECPSIFAWEIRDRLLSDGVCTNDNIPSVSSINRVLRNLASEKQQMGSDGMYDKLRMLNGQTGTWGARPGWYPGTSVPGQPAQEGCQPQEGGAENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALSNSYSALPPMPSFTMGNNLPMQPPVPSQPSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ		Refseq >NP_001165666\|paired box protein Pax-6 [Xenopus laevis] MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVNKIAHYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASDKQQMGSEGMYDKLRMLNGQTATWGSRPGWYPGTSVPGQPAQEGCQPQEGVGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGAMLGRTDTALTNSYSALPPMPSFTMGNNLPMQVSFPLECQSQFKYPAVNLTCLSTGQDYSKNRVNLTNDFMENSWMFSSIL UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.20625 [+] Str.44794	Xl.85439		Xl.647
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		102 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PAX6	OMIM:106210 OMIM:120200 OMIM:129750 OMIM:136520 OMIM:148190 OMIM:165550 OMIM:603807 OMIM:604219 OMIM:604229 OMIM:120430 OMIM:206700
mouse		MGI	Pax6	All(39) Targeted, knock Out(3) Targeted, other(4) Radiation Induced(5) Chemically Induced(23) Spontaneous(2)
zebrafish		ZFIN ZFIN	pax6a pax6b	1 Lines(s) 7 Lines(s)

Publications
First:		A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase. [Proc Natl Acad Sci U S A 1987]
Most recent:		Gene expression responses for detecting sublethal effects of xenobiotics and whole effluents on a Xenopus laevis embryo assay. [Environ Toxicol Chem 2013]
		View All Papers 40 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		multicellular organismal development regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor PRD and related proteins, contain PAX and HOX domains

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.20625.1.S1_at [+] Str.44794.1.S1_at	Xl.647.1.S1_a_at [+] Xl.647.3.S1_x_at		Xl.647.4.S1_x_at [+] Xl.647.2.S2_at Xl.647.6.S1_x_at
Affymetrix 2.0			Xl2.647.2.S1_a_at		Xl2.647.3.S2_at

Symbol legend[+]