Gene Symbol: tp53 Gene Name: tumor protein p53 Synonyms: p53, Xp53, Li-Fraumeni syndrome Add Xenopus synonyms Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling Interactants: mdm2(13) , cdkn1a(12) , myc(8) , tgfb1(7) , tp63(7) , atm(6) , aurka(6) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001001903|Xenopus (Silurana) tropicalis tumor protein p53 (tp53), mRNA GCCGAGAGGAACGGACCGGATAGAAACAGAGCGACCGATTCTTGTTCCGTTACCGACACTTTCCGGCCTGTGATCTGGTTCTGCCATGGAACCTTCTTCTGAGACCGGCATGGAGCCGCCCCTCAGCCAGGAGACCTTCGAGGATTTGTGGAGCCTGTTGCCGGACCCCCTACAGACCGGGACAGGTCAGATGGAAAACTTTGCGGAGTTTTCAGAGTACCCCCTGGCGCCAGACATGACGGTTCTGCAGGAAGGGCTTATGGGTAATACCGTGCCCACCGTGACTTCGTCTGCTGTCCCCTCAACTGAGGATTACGCAGGGAGCTACGGGCTCAAATTGGAGTTCCAACAGAATGGAACCGCAAAGTCTGTTACCTGCACATACTCCACCGACCTCAACAAGCTCTTCTGCCAATTGGCCAAGACCTGCCCTTTGCTGGTCCGTGTGGAGAGACCCCCGCCGCTCGGCTCCATTCTCCGGGCTACGGCCGTGTACAAGAAATCCGAGCACGTGGCCGAGGTGGTCAAGAGGTGCCCCCACCATGAGCGCAGCGTGGAGCCAGGGGATGACCCTGCCCCTCCCAGTCACCTGATGCGCGTGGAGGGAAATTCAAAGGCTTATTATATGGAGGATGTTGGTACCGGGCGCCATAGTGTCTGTGTGCCCTATGAGGGCCCTCAGGTCGGAACCGAATGTACCACCGTTCTGTACAACTATATGTGTAACAGCTCGTGTATGGGTGGGATGAACCGCCGGCCCATTCTCACTATTATCACCCTGGAGTCCCCAGAGGGGCTGCTGCTTGGCCGCCGCTGCTTTGAGGTTCGTGTGTGCGCCTGCCCCGGGAGGGATCGTCGCACAGAAGAAGATAATTGCACAAAGAAACGGGGCCTGAAACCCAACGGGAAGAGAGAGCTTTCTCACCCACCATCCAGTGACCCTCCACTTCCCAAGAAGCGCCTTGTTGAGGAGGATGATGAAGAGACCTTCACCTTGCTGATTAAGGGGCGGAGCCGCTATGAGATGATAAAGAAACTGAATGACGCACTTGAATTACAAGAGAGCCTCGACCAGCAGAAACTGTCCATAAAGTGCCGCAAGTGCCGGGACGAGATCAAACCCAAGAAAGGGAAGAAGCTGCTGGTGAAAGATGAGCTGCAGGACTCCGAGTGAGACCCCGACGGGAGCCAGCACTTGGGGGGCATCGGTGGCCGGTTCTCCGACTTTTGTTTTTTTTGTTTTGTTTTTTTTTTAAGCTCTGTCCCTCCTTTTAGCTAGTTTAGAGGGTCCGCATTGCCCTTGGGGGGCCCGCTAGTTCTATATGGCACCCAATATTATCCAGTCATTATGTGTTTGGGGGCTCAATTACACTGTTTACTCTGTATCATTGTAAGAGATGGGGGTACACCCCCCCACCCTGATAATGCATTTAAGGAAAATGAATGTCATATTGTTGTGGCCCACGAACAAAGTACCAAGGTCCCCCTGGCCCGCCCAGTCTGTGGTTCCAGTGCATTATGGGGCACTGGGTCAGGCTGTGTGGGTCACCCAATCAGTGAGGTGGCACCCCACTTGGGTAAAGGGAGGGCCTCTACTCCTGCCAACCTGTTAGTCATTGACTCCTGTAAGGAGGAGCTAATGCAGTGGGGGAGGGGCTTAAGGACAGGCAAAATAGTTCCCTTTCCATTGGCCAAAGTGATGGTGTTGGCCCTTACTGGGGCTGAATCCCATAATGCATCTGTAGGGCTCGGGACGGCCCAGTGTACGCATCAGAGGGTGGAGCTTCCTGCAGATTGAGTTGAATTCCCCCTTGAGTGGGGAATGTATTGGAGTGGGATAGGCCCCGCCCATCCAGGGTTCTGCTGACTGCCACCTTATTATGTAACCCTGTGGGTGAGGGTGTGAATGGTATGTGCCCAGTGTGGGAGGGATATAACTGCCACTCCTACCCCCCCATACAGACTCTCCTGGCATGCCAGCATGGTGGGCACTGTATGGGTTCATTGCTGCTCCGGTGTAGTGGCACCTATGCCTCTGGGGGTGCTAGAGAGCTCAGGGAGTTTCCCAGGCAGGGGCAATAAGAGGCCCGGGGGGTAAGATTTAGGCTCTGAAGGGCAGTTATATCGACATTTCATGGAGATTAGCGCCACATTTCCTCCCTTCAGCGCCAAATGGGTTATGGGCATCAATGGGTTATGGGCATCATTATTCGGTTGCTGGGGCTCCCCCAGATCTGCCCCTGTCTCCCCCCCCAAATGTGCCCCTGTCTCCCCATAACCTTCCTTTTTACTAACACTCACTGCCAATGAATTTTGTATCTTCTTTTTTTAATAAAAAAAATCCAGTAATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088098|Xenopus laevis tumor protein p53 (tp53), mRNA GGAATTCCGCCCCGACTCGAGGAAGCAGAGAGGATAGAATCAGAGTCGCCATTTCTTTGGTTCCCGTTACCGGTCCTTTGCAGCGAGCCACCCCTCTGCTGCCTCCATAATGGAACCTTCCTCTGAGACCGGCATGGACCCCCCCCTCAGCCAGGAGACATTCGAGGATCTGTGGAGTCTGTTGCCTGACCCCCTGCAGACTGTCACGTGTCGGCTGGACAACCTATCAGAGTTTCCAGACTATCCCCTGGCAGCAGACATGACGGTCCTACAGGAGGGGCTTATGGGTAATGCTGTTCCCACCGTCACTTCATGTGCTGTCCCCTCAACTGACGATTATGCTGGGAAGTATGGGCTCCAACTGGACTTCCAACAGAACGGCACCGCAAAGTCTGTTACCTGCACGTATTCCCCAGAGCTCAACAAACTCTTCTGCCAGTTGGCCAAGACTTGCCCTTTGCTGGTGCGTGTGGAGAGCCCCCCGCCTCGCGGCTCCATTCTCCGGGCTACGGCCGTCTACAAGAAATCTGAGCATGTGGCCGAGGTGGTGAAGAGATGCCCCCACCATGAGCGCAGTGTGGAGCCAGGGGAGGATGCTGCGCCTCCCAGTCACCTGATGCGAGTGGAGGGAAATCTCCAGGCTTATTATATGGAGGATGTAAATAGCGGGCGCCATAGTGTCTGTGTTCCCTATGAGGGGCCTCAGGTTGGAACGGAATGTACAACAGTTCTGTACAATTATATGTGTAACAGCTCCTGTATGGGAGGGATGAACCGCCGGCCCATTCTCACCATCATCACCCTCGAGACCCCACAGGGGCTACTTCTTGGCCGCCGCTGTTTTGAGGTTCGAGTGTGTGCCTGCCCAGGGAGGGATCGTCGCACAGAGGAAGACAATTACACAAAAAAGAGGGGCCTGAAACCCAGCGGCAAGAGAGAACTTGCTCACCCACCATCCAGTGAACCACCACTTCCTAAGAAGCGTCTTGTTGTTGTTGATGATGATGAAGAAATCTTCACTTTGCGGATTAAGGGGCGCAGCCGCTATGAGATGATTAAGAAACTGAATGACGCACTTGAATTACAAGAAAGCCTCGATCAGCAGAAAGTGACCATTAAGTGCCGCAAGTGCCGGGATGAAATCAAACCCAAGAAAGGAAAGAAGCTGCTGGTTAAAGATGAACAGCCCGACTCGGAATGAGGACCCCGAATGAATGTAACGAACAGTTAGGGGGGATATCGGTGGCCGGTTCTCCGATCGTTTTGTTTTCTTTAAACTGCCTCCCTCCTTTTAGTTAGTTTAGAGGTTCAGTATTGCCTGTTTCATGTAGCACCCAATATGTTTATCCAGTTAGTCATTATGGGTTGGAGGCTCCATTACACCCTTTATGGGTTCACTGTAAGATATGGGGGTACACGCTCTCCCCCTATAATGTATTTAAGGGAAACAAATGTCATATCAGGATTGTTGTACAATTAAAGGCACATGAACCCTGTCTGAGCAGAAACAAAGCAATAGGGCCCCCGACCCACCGTGTCTCTGGTTCCAGTGCATTATGGGAAGCCTGTACTTTATGGACTGGTACCCAGTCACTGTGTGGGTGGGGCTTGTCTCTTCCTCAGGGAAAGTCAAACCCTCTACGCCTGCCCCTCCTGGAGGCGGAGTAAATGCAGTGGGGGAGGGGCTTCGATTCAATTCCACTGGCCAAGGAGCTGATTATGGGACGGTGAGAAGGAGGTAGGTGGGAAACCGGCTCTTACTGGGCTTCAGTCCCATAATGCATCTGTGTGTGGGACAACCAGTTATTTATTTGGGCTAGCTGCAGGCTTTTTATTATGTGACCCTATTTGTGAGGATATGAATGAGCCCTGCTGTGGCCAGTTTGGGAGGGGTAATAGTGCCCTCCAGCCATAGCACTGGGTGAGCCATACACAGAATGAGTTGGTCGCTCCCTGCATGTGGGGGGGGCAGTTGTATTTCCCTCCTCCAACACGGGTTATGCACATTGTAAATTCTCAATCAGGTTCCAGATAAAATTCTCTGATCATTCTTCAACTGCTGGGGCTCCCCCAAATCTGCCCCTGTCTCCCCCAATACTTCCTTTGTACTAACACTCACTGCCATCCAAATTTTGTATTTTTCTTTTTTTAATAAAAATTCTATTAATCTATAAAAAAAAAAAAACGAATTC
Protein		Refseq >NP_001001903|tumor protein p53 [Xenopus (Silurana) tropicalis] MEPSSETGMEPPLSQETFEDLWSLLPDPLQTGTGQMENFAEFSEYPLAPDMTVLQEGLMGNTVPTVTSSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCTYSTDLNKLFCQLAKTCPLLVRVERPPPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGDDPAPPSHLMRVEGNSKAYYMEDVGTGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLESPEGLLLGRRCFEVRVCACPGRDRRTEEDNCTKKRGLKPNGKRELSHPPSSDPPLPKKRLVEEDDEETFTLLIKGRSRYEMIKKLNDALELQESLDQQKLSIKCRKCRDEIKPKKGKKLLVKDELQDSE	Refseq >NP_001081567|cellular tumor antigen p53 [Xenopus laevis] MEPSSETGMDPPLSQETFEDLWSLLPDPLQTVTCRLDNLSEFPDYPLAADMTVLQEGLMGNAVPTVTSCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACPGRDRRTEEDNYTKKRGLKPSGKRELAHPPSSEPPLPKKRLVVVDDDEEIFTLRIKGRSRYEMIKKLNDALELQESLDQQKVTIKCRKCRDEIKPKKGKKLLVKDEQPDSE UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.11712 [+] Str.48473 Str.54691	Xl.394
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		5 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tneu034a23

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	TP53	OMIM:114550 OMIM:114500 OMIM:202300 OMIM:114480 OMIM:151623 OMIM:161550 OMIM:260350
mouse		MGI	Trp53	All(73) Targeted, knock Out(9) Targeted, other(52) Chemically Induced(2)
zebrafish		ZFIN	tp53	60 Lines(s)

Publications
First:		Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. [Oncogene 1987]
Most recent:		Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. [Hum Mol Genet 2013]
		View All Papers 9 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.6676.1.S1_at [+] Str.11712.1.A1_at	Xl.394.1.S1_at
Affymetrix 2.0			Xl2.394.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images