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Summary Expression Gene Literature (199) GO Terms (30) Nucleotides (343) Proteins (28) Interactants (1697) Wiki
XB-GENEPAGE-484285

Gene Symbol: tp53

Gene Name: tumor protein p53

Synonyms: p53 , Xp53 , Trp248 , Xrel3 , tumor suppressor p53 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling

Protein Function :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]

Interactants: Loading ...
Disease Ontology: breast cancer [+]

OMIM Diseases: HEPATOCELLULAR CARCINOMA [+]

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Xenbase Gene ID XB-GENE-484286 XB-GENE-6252168 XB-GENE-17346471
Gene Symbol tp53 tp53.L tp53.S
Chromosome scaffold_393 chr3L Scaffold20
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL TrEMBL TrEMBL Refseq Swiss-Prot Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine tp53 tp53.L tp53.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tneu034a23      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards TP53 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Trp53 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR tp53 ZFIN Ensembl
chicken
GEISHA TP53 Ensembl
fruit fly
worm
WORMBASE
Publications
First Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53., Oncogene 1987  
Most Recent X-linked α-thalassemia with mental retardation is downstream of protein kinase A in the meiotic cell cycle signaling cascade in Xenopus oocytes and is dynamically regulated in response to DNA damage†., Biol Reprod 2019  
All View All Papers 22 paper(s) referencing morpholinos 7 paper(s) referencing OMIMs 13 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 28 terms 13 terms 0 term
PANTHER tp53
KEGG Pathways K04451 K04451
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s)  
Dharmacon Dharmacon Dharmacon
Morpholino tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4
ORF tp53 ORF1 tp53.L ORF1
Affymetrix 1.0 Str.6676.1.S1_at [+] Xl.394.1.S1_at
Affymetrix 2.0 Xl2.394.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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