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XB-GENEPAGE-484285
Gene Symbol:
tp53
Gene Name: tumor protein p53
Synonyms:
p53
,
Xp53
,
Trp248
,
Xrel3
,
tumor suppressor p53
( Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling Protein Function
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]
InterPro
![]() Interactants:
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Diseases: Disease Ontology:
chronic lymphocytic leukemia
OMIM:
HEPATOCELLULAR CARCINOMA
External Links:
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Xenbase Gene ID | XB-GENE-484286 | XB-GENE-6252168 | XB-GENE-17346471 | |||||
Gene Symbol | tp53 | tp53.L | tp53.S | Chromosome | Chr3 | chr3L | Scaffold20 | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
431679
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397926
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108703451
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mRNA |
RefSeq
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser)
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | tp53 | tp53.L | tp53.S | |||||
Phenotype | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Smith Morpholino Screen | tneu034a23 | |||||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53., Oncogene 1987 |
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Most Recent |
Rab11fip5 regulates telencephalon development via ephrinB1 recycling., Development 2021 ![]() |
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All | View All Papers 22 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 18 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 49 terms | 13 terms | 0 term | |||||
PANTHER | tp53 | |||||||
KEGG Pathways | K04451 [+] | K04451 | ||||||
KOG | ||||||||
Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | tp53 | |||||||
Mutants | Xtr.tp53em_del1/+_Vlemx , Xtr.tp53em_del2/+_Vlemx , Xtr.tp53em_del1/em_del2_Vlemx | |||||||
Antibodies | Tp53 Ab1 | Tp53 Ab1 | Tp53 Ab1 | |||||
Morpholinos (on-target & off-target) | tp53 MO1 , tp53 MO4 , tp53 MO2 , tp53 MO3 | |||||||
ORFs | tp53 ORF1 | tp53.L ORF1 | ||||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon | |||||
Plasmids | Addgene | Addgene |
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