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Summary Expression Gene Literature (183) GO Terms (10) Nucleotides (341) Proteins (27) Interactants (1124) Wiki
XB-GENEPAGE- 484285

Gene Symbol: tp53

Gene Name: tumor protein p53

Synonyms: p53 , Xp53 , Trp248 , Xrel3 , tumor suppressor p53
Add Xenopus synonyms , Nomenclature history


Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling

Protein Function:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]


Interactants: YYY

OMIM Disease Associations: HEPATOCELLULAR CARCINOMA [+]
1/2
 
Xenbase Gene ID XB-GENE-484286 XB-GENE-6252168 XB-GENE-17346471
Gene Symbol tp53 tp53.L tp53.S
Chromosome scaffold_393 chr3L Scaffold20
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.11712 [+] Xl.394
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 8 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine tp53 tp53.L tp53.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tneu034a23      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards TP53 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Trp53 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN tp53 ZFIN Ensembl
chicken
GEISHA TP53 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. [Oncogene 1987]
Most recent: Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. [Elife 2017]
View All Papers 22 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 10 terms 10 terms 0 term
EC
PANTHER tp53
KEGG Pathways K04451 K04451
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4
ORF tp53 ORF1
Affymetrix 1.0 Str.6676.1.S1_at [+] Xl.394.1.S1_at
Affymetrix 2.0 Xl2.394.1.S1_at

Symbol legend[+]

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