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XB-GENEPAGE-
484285
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Gene Symbol: tp53
Gene Name: tumor protein p53 Synonyms: p53 , Xp53 , Trp248 , Xrel3 , tumor suppressor p53 Add Xenopus synonyms , Nomenclature history Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling Protein Function  :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]
Interactants: Loading ... 
OMIM Disease Associations: HEPATOCELLULAR CARCINOMA |
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1/4 | Xenbase Gene ID | XB-GENE-484286 | XB-GENE-6252168 | XB-GENE-17346471 | ||||
| Gene Symbol | tp53 | tp53.L | tp53.S | ||||
| Chromosome | scaffold_393 | chr3L | Scaffold20 | ||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||
| Gene |
Genomic sequence
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Genomic sequence
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Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
Refseq
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Refseq
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| Protein
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Refseq
TrEMBL
TrEMBL
TrEMBL
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Refseq
Swiss-Prot
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| Genomic | tropicalis | laevis.L | laevis.S | ||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus | ||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||
| Ensembl | Ensembl | ||||||
| UniGene | Str.11712 [+] | Xl.394 | |||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 11 expression image(s) for tropicalis and laevis | ||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||
| XenMine | tp53 | tp53.L | tp53.S | ||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||
| Smith Morpholino Screen | tneu034a23 | ||||||
| Orthology |
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| fruit fly |
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| Publications | |||||||
| First: | Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. [Oncogene 1987] | ||||||
| Most recent: |
Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. [Dev Cell 2018]
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| View All Papers 22 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs | |||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||
| GO | 28 terms | 10 terms | 0 term | ||||
| PANTHER | tp53 | ||||||
| KEGG Pathways | K04451 | K04451 | |||||
| KOG | |||||||
| Reagents | tropicalis | laevis.L | laevis.S | ||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||
| Clones | EXRC - 1 clone(s) | ||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||
| Source BioScience | Source BioScience | ||||||
| Morpholino | tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 | tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 | tp53 MO1 , tp53 MO2 , tp53 MO3 , tp53 MO4 | ||||
| ORF | tp53 ORF1 | ||||||
| Affymetrix 1.0 | Str.6676.1.S1_at [+] | Xl.394.1.S1_at | |||||
| Affymetrix 2.0 | Xl2.394.1.S1_at | ||||||
Symbol legend[+]
