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Summary Expression Gene Literature (216) GO Terms (51) Nucleotides (359) Proteins (41) Interactants (1780) Wiki
XB-GENEPAGE-484285
Gene Symbol:
tp53

Gene Name:
tumor protein p53

Synonyms:
p53 , Xp53 , Trp248 , Xrel3 , tumor suppressor p53 ( Add synonyms , Nomenclature history )

Gene Function:
transcription factor regulating cell cycle, apoptosis and TGF-beta signaling

Protein Function :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]


InterPro :
RecA ATP-bd , DNA repair Rad51/TF NusA a-hlx , DNA recomb/repair Rad51 C , RecA monomer-monomer interface [+]

Interactants:
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Diseases: 


Disease Ontology:
chronic lymphocytic leukemia [+]

OMIM:
HEPATOCELLULAR CARCINOMA [+]

External Links:
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Xenbase Gene ID XB-GENE-484286 XB-GENE-6252168 XB-GENE-17346471
Gene Symbol tp53 tp53.L tp53.S
Chromosome Chr3 chr3L Scaffold20
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 431679
397926
108703451
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tp53 tp53.L tp53.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu034a23      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TP53 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Trp53 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tp53 Ensembl
zebrafish
ZFIN, AGR tp53 ZFIN Ensembl
chicken
GEISHA TP53 Ensembl
fruit fly
worm
Publications
First Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53., Oncogene 1987  
Most Recent Rab11fip5 regulates telencephalon development via ephrinB1 recycling., Development 2021                                                              
All View All Papers 22 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 18 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 49 terms 13 terms 0 term
PANTHER tp53
KEGG Pathways K04451 [+] K04451
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tp53
Mutants Xtr.tp53em_del1/+_Vlemx , Xtr.tp53em_del2/+_Vlemx , Xtr.tp53em_del1/em_del2_Vlemx
Antibodies Tp53 Ab1 Tp53 Ab1 Tp53 Ab1
Morpholinos (on-target & off-target) tp53 MO1 , tp53 MO4 , tp53 MO2 , tp53 MO3
ORFs tp53 ORF1 tp53.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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