Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (217) GO Terms (51) Nucleotides (359) Proteins (41) Interactants (1780) Wiki
Gene Symbol:

Gene Name:
tumor protein p53

p53 , Xp53 , Trp248 , Xrel3 , tumor suppressor p53 ( Add synonyms , Nomenclature history )

Gene Function:
transcription factor regulating cell cycle, apoptosis and TGF-beta signaling

Protein Function :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator tha...[+]

InterPro :
RecA ATP-bd , DNA repair Rad51/TF NusA a-hlx , DNA recomb/repair Rad51 C , RecA monomer-monomer interface [+]

Loading ...


Disease Ontology:
chronic lymphocytic leukemia [+]


External Links:
Xenbase Gene ID XB-GENE-484286 XB-GENE-6252168 XB-GENE-17346471
Gene Symbol tp53 tp53.L tp53.S
Chromosome Chr3 chr3L Scaffold20
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 431679
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tp53 tp53.L tp53.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu034a23      
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC, AGR, Monarch, OMIM, GeneCards TP53 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Trp53 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Tp53 Ensembl
ZFIN, AGR tp53 ZFIN Ensembl
GEISHA TP53 Ensembl
fruit fly
First Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53., Oncogene 1987  
Most Recent High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability., BMC Cancer 2021  
All View All Papers 22 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 19 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 49 terms 13 terms 0 term
KEGG Pathways K04451 [+] K04451
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tp53
Mutants Xtr.tp53em_del1/+_Vlemx , Xtr.tp53em_del2/+_Vlemx , Xtr.tp53em_del1/em_del2_Vlemx
Antibodies Tp53 Ab1 Tp53 Ab1 Tp53 Ab1
Morpholinos tp53 MO1 , tp53 MO4 , tp53 MO2 , tp53 MO3
ORFs tp53 ORF1 tp53.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info