Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (151) GO Terms (29) Nucleotides (319) Proteins (53) Interactants (1421) Wiki
XB-GENEPAGE-484294
Gene Symbol:
sox17a

Gene Name:
SRY-box 17 alpha

Synonyms:
xSox17alpha1 , xSox17alpha2 , tSox17alpha , Xsox17-alpha , Sox17alpha , sox17-alpha , xsox17a , xsox17 , Xsox17alpha , sox17 alpha ( Add synonyms , Nomenclature history )

Gene Function:
HMG-box transcription factor

Protein Function :
Transcription activator. Binds to the DNA sequence 5'-AACAAT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in functi...[+]


InterPro :
Sox C , HMG box dom sf , HMG box dom , Sox7/17/18 central

Interactants:
Loading ...

Diseases: 


Disease Ontology:
vesicoureteral reflux

OMIM:
VESICOURETERAL REFLUX 3; VUR3

External Links:
1/5
 
Xenbase Gene ID XB-GENE-484295 XB-GENE-865067 XB-GENE-6255435
Gene Symbol sox17a sox17a.L sox17a.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 395066
397966
398765
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine sox17a sox17a.L sox17a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, GeneCards SOX17 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Sox17 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
zebrafish
ZFIN, AGR sox17 ZFIN Ensembl
chicken
GEISHA SOX17 Ensembl
fruit fly
worm
Publications
First Xsox17alpha and -beta mediate endoderm formation in Xenopus., Cell 1997    
Most Recent Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network., Elife 2020                        
All View All Papers 41 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 23 terms 13 terms 10 terms
PANTHER sox17a
KEGG Pathways K04495 K04495 K04495
KOG [K] HMG-box transcription factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks sox17a
Antibodies Sox17a Ab1 , Sox17a/b Ab2 Sox17a Ab1 , Sox17a/b Ab2 Sox17a/b Ab2 , Sox17a Ab1
Morpholinos sox17a MO1 , sox17a MO2 , sox17a MO3 , sox17a MO4 , sox17a MO5 sox17a MO1 , sox17a MO2 , sox17a MO3 , sox17a MO4 , sox17a MO5 sox17a MO1 , sox17a MO2 , sox17a MO3 , sox17a MO4 , sox17a MO5
ORFs sox17a ORF1 sox17a.L ORF1 sox17a.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556