|
XB-GENEPAGE-
484424
|
Gene Symbol: ptf1a
Gene Name: pancreas associated transcription factor 1a Synonyms: Ptf1a/p48 , XPtf1a , ptf1a-a , ptf1a-b Add Xenopus synonyms , Nomenclature history Gene Function: transcription factor Protein Function  :
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the...[+]
Interactants: Loading ... 
OMIM Disease Associations: PANCREATIC AND CEREBELLAR AGENESIS; PACA |
|
1/2 | Xenbase Gene ID | XB-GENE-484425 | XB-GENE-484429 | XB-GENE-6466546 | ||||||
| Gene Symbol | ptf1a | ptf1a.L | ptf1a.S | ||||||
| Chromosome | Chr06 | Scaffold18689 | Scaffold155082 | ||||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||||
| Gene |
Genomic sequence
|
Genomic sequence
|
Genomic sequence
|
||||||
| CDS |
Gene model
|
||||||||
|
Entrez Gene
|
Entrez Gene
|
||||||||
| mRNA |
NCBI Nucleotide
|
NCBI Nucleotide
|
Refseq
|
||||||
| Protein
|
NCBI Protein
TrEMBL
|
NCBI Protein
|
Refseq
Swiss-Prot
Swiss-Prot
TrEMBL
|
||||||
| Genomic | tropicalis | laevis.L | laevis.S | ||||||
| Genome Browser |
|
||||||||
| Links |
|
||||||||
| Genomic Synteny | Genomicus | ||||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||||
| Ensembl | Ensembl | ||||||||
| UniGene | Str.36339 | Xl.29862 | Xl.85876 | ||||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
|
|||||||
| Experimental regulation |
Regulation heatmap:
|
||||||||
| Images | 30 expression image(s) for tropicalis and laevis | ||||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||||
| XenMine | ptf1a | ptf1a.L | ptf1a.S | ||||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||||
| Smith Morpholino Screen | |||||||||
| Orthology |
|
||||||||
| human |
|
||||||||
| mouse |
|
||||||||
| zebrafish |
|
||||||||
| chicken |
|
||||||||
| fruit fly |
|
||||||||
| worm |
|
||||||||
| Publications | |||||||||
| First: |
Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. [Genes Dev 2006]
|
||||||||
| Most recent: |
Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina. [Neural Dev 2017]
|
||||||||
| View All Papers 11 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs | |||||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||||
| GO | 7 terms | 0 term | 14 terms | ||||||
| PANTHER | ptf1a | ||||||||
| KEGG Pathways | K09073 | ||||||||
| KOG |
[K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
|
||||||||
| Reagents | tropicalis | laevis.L | laevis.S | ||||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||||
| Clones | EXRC - 1 clone(s) | EXRC - 1 clone(s) | |||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||||
| Source BioScience | Source BioScience | Source BioScience | |||||||
| Morpholino | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ||||||
| Affymetrix 1.0 | Str.36339.1.S1_at | ||||||||
| Affymetrix 2.0 | Xl2.29862.1.S1_at | ||||||||
Symbol legend[+]
