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XB-GENEPAGE-
484424
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Gene Symbol: ptf1a
Gene Name: pancreas associated transcription factor 1a Synonyms: Ptf1a/p48 , XPtf1a , ptf1a-a , ptf1a-b Add Xenopus synonyms , Nomenclature history Gene Function: transcription factor Protein Function  :
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the...[+]
Interactants: Loading ... 
Disease Ontology: OMIM Diseases: PANCREATIC AND CEREBELLAR AGENESIS; PACA |
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1/2 | Xenbase Gene ID | XB-GENE-484425 | XB-GENE-484429 | XB-GENE-6466546 | ||||
| Gene Symbol | ptf1a | ptf1a.L | ptf1a.S | ||||
| Chromosome | Chr06 | Scaffold18689 | Scaffold155082 | ||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||
| Gene |
Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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| mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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Refseq
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| Protein
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NCBI Protein
TrEMBL
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NCBI Protein
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Refseq
Swiss-Prot
Swiss-Prot
TrEMBL
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| Genomic | tropicalis | laevis.L | laevis.S | ||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus PANTHER | ||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||
| Ensembl | Ensembl | ||||||
| UniGene | Str.36339 | Xl.29862 | Xl.85876 | ||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 30 expression image(s) for tropicalis and laevis | ||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||
| XenMine | ptf1a | ptf1a.L | ptf1a.S | ||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||
| Smith Morpholino Screen | |||||||
| Orthology |
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| human |
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| mouse |
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| zebrafish |
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| chicken |
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| fruit fly |
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| worm |
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| Publications | |||||||
| First: |
Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. [Genes Dev 2006]
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| Most recent: |
Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis. [Development 2018]
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| View All Papers 11 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology | |||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||
| GO | 7 terms | 0 term | 14 terms | ||||
| PANTHER | ptf1a | ||||||
| KEGG Pathways | K09073 | ||||||
| KOG |
[K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
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| Reagents | tropicalis | laevis.L | laevis.S | ||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||
| Clones | EXRC - 1 clone(s) | EXRC - 1 clone(s) | |||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||
| Source BioScience | Source BioScience | Source BioScience | |||||
| Morpholino | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ptf1a MO1 , ptf1a MO2 , ptf1a MO3 | ||||
| Affymetrix 1.0 | Str.36339.1.S1_at | ||||||
| Affymetrix 2.0 | Xl2.29862.1.S1_at | ||||||
Symbol legend[+]
