Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (28) GO Terms (14) Nucleotides (49) Proteins (21) Interactants (189) Wiki
XB-GENEPAGE- 484424

Gene Symbol: ptf1a

Gene Name: pancreas specific transcription factor, 1a

Synonyms: Ptf1a/p48 , XPtf1a , ptf1a-a , ptf1a-b
Add Xenopus synonyms , Nomenclature history


Gene Function: transcription factor

Protein Function:
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the...[+]


Interactants: YYY

OMIM Disease Associations: PANCREATIC AND CEREBELLAR AGENESIS; PACA
1/2
 
Xenbase Gene ID XB-GENE-484425 XB-GENE-484429 XB-GENE-6466546
Gene Symbol ptf1a ptf1a.L ptf1a.S
Chromosome scaffold_6 Scaffold18689 Scaffold155082
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 6.0 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide NCBI Nucleotide Refseq
Protein NCBI Protein NCBI Protein Refseq Swiss-Prot Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v6.0 gene model
GBrowse
laevis genome v7.2 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.36339 Xl.29862 Xl.85876
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 25 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine ptf1a ptf1a.L ptf1a.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PTF1A OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Ptf1a MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ptf1a ZFIN Ensembl
chicken
GEISHA PTF1A Ensembl
fruit fly
worm
WORMBASE
Publications
First: Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. [Genes Dev 2006]
Most recent: Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina. [Neural Dev 2017]
View All Papers 11 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 14 terms
EC
PANTHER ptf1a
KEGG Pathways K09073
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s) EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino ptf1a MO1 , ptf1a MO2 , ptf1a MO3 ptf1a MO1 , ptf1a MO2 , ptf1a MO3 ptf1a MO1 , ptf1a MO2 , ptf1a MO3
Affymetrix 1.0 Str.36339.1.S1_at
Affymetrix 2.0 Xl2.29862.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556