Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (35) GO Terms (21) Nucleotides (59) Proteins (29) Interactants (255) Wiki
XB-GENEPAGE-484424
Gene Symbol:
ptf1a

Gene Name:
pancreas associated transcription factor 1a

Synonyms:
Ptf1a/p48 , XPtf1a , ptf1a-a , ptf1a-b ( Add synonyms , Nomenclature history )

Gene Function:
transcription factor

Protein Function :
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the...[+]


InterPro :
AA/rel permease1 , HLH DNA-bd sf , bHLH dom

Interactants:
Loading ...

Diseases: 


Disease Ontology:
pancreatic agenesis

OMIM:
PANCREATIC AND CEREBELLAR AGENESIS; PACA [+]

External Links:
1/4
 
Xenbase Gene ID XB-GENE-484425 XB-GENE-6466546 XB-GENE-484429
Gene Symbol ptf1a ptf1a.L ptf1a.S
Chromosome Chr6 chr6L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2
CDS Gene model Gene model
Entrez Gene 100494161
100381084
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ptf1a ptf1a.L ptf1a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards PTF1A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ptf1a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ptf1a Ensembl
zebrafish
ZFIN, AGR ptf1a ZFIN Ensembl
chicken
GEISHA PTF1A Ensembl
fruit fly
Publications
First The RNA-binding protein, Vg1RBP, is required for pancreatic fate specification., Dev Biol 2006                        
Most Recent CRISPR/Cas9 disease models in zebrafish and Xenopus: The genetic renaissance of fish and frogs., Drug Discov Today Technol 2018  
All View All Papers 12 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 12 terms 0 term
PANTHER ptf1a
KEGG Pathways K09073 K09073
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ptf1a
Morpholinos ptf1a MO2 , ptf1a MO3
Clones EXRC Horizon Source BioScience Horizon Source BioScience Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info