Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (497) GO Terms (30) Nucleotides (527) Proteins (42) Interactants (2550) Wiki
XB-GENEPAGE-484552
Gene Symbol:
sox2

Gene Name:
SRY-box 2

Synonyms:
XLSOX-2 , Sox-2 , XSox2 , Xsox-2 , anop3 , mcops3 ( Add synonyms , Nomenclature history )

Gene Function:
HMG-box transcription factor

Protein Function :
Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells resp...[+]


InterPro :
SOX-2 , SOX fam , HMG box dom sf , HMG box dom

Interactants:
Loading ...

Diseases: 


Disease Ontology:
septooptic dysplasia [+]

OMIM:
MICROPHTHALMIA, SYNDROMIC 3; MCOPS3 [+]

External Links:
1/8
 
Xenbase Gene ID XB-GENE-484553 XB-GENE-865099 XB-GENE-17341038
Gene Symbol sox2 sox2.L sox2.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 407873
398000
mRNA NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine sox2 sox2.L sox2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards SOX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Sox2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Sox2 Ensembl
zebrafish
ZFIN, AGR sox2 ZFIN Ensembl
chicken
GEISHA SOX2 Ensembl
fruit fly
Publications
First Neural crest formation in Xenopus laevis: mechanisms of Xslug induction., Dev Biol 1996          
Most Recent Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage., Biol Open 2021                  
All View All Papers 145 paper(s) referencing morpholinos 17 paper(s) referencing OMIMs 24 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 29 terms 8 terms 0 term
PANTHER sox2
KEGG Pathways K16796 K16796
KOG [K] HMG-box transcription factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks sox2
Antibodies Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab2 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8 Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8 Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8
Morpholinos sox2 MO1 , sox2 MO3 , sox2 MO2
ORFs sox2 ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info