sox2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (200)

Nucleotides (513)

Interactants (648)

XB-GENEPAGE-484552

Gene Symbol: sox2 Gene Name: SRY (sex determining region Y)-box 2 Synonyms: XLSOX-2, Sox-2, XSox2, Xsox-2, anop3, mcops3 Add Xenopus synonyms Gene Function: HMG-box transcription factor Interactants: chrd(59) , snai2(57) , t(46) , otx2(44) , bmp4(42) , tubb2b(39) , nog(38) View All	1/4

XB-GENE-484553

XB-GENE-865099

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_213704\|Xenopus (Silurana) tropicalis SRY (sex determining region Y)-box 2 (sox2), mRNA CCGGGATTCCATTTATTCCCTGACAGCCCACATCACATGGACGGTTGTCTATTAACTTGTTTCAAAAAAGTAGCAGGACTTGTCACACGCTCAGGGAGGGAGAGCAGTTGGCTCAGCTGCCCGAGAGCAGAGAGAGAAAGTGAGGCAGCAACGGCGGCAGCGGCGGCGGGAGAGAGAGAAAGTGAAGAGAGTTTGGGAAACTGTGTGTCAGTGCCCCCCTGATTCCGCCGTGCCAGGCTTTGCTACCCACAGGCCGCCTGAATGTACAACATGATGGAGACCGATCTCAAGCCCCCCGCCCCCCAGCAGGCTTCGGGGGGCAACTCCAACTCGGGCTCCAACAACCAGAGTAAGAACAGCCCGGATCGAGTCAAGAGACCCATGAATGCCTTCATGGTATGGTCCAGGGGCCAGAGGAGAAAGATGGCTCAGGAGAACCCCAAGATGCACAACTCAGAGATCAGCAAGAGACTGGGGGCTGAGTGGAAGCTGCTCTCCGAGGCCGAGAAAAGACCATTCATCGACGAGGCCAAGAGGCTGCGAGCTCTGCACATGAAGGAGCATCCGGATTATAAATACAGGCCCAGGAGGAAAACCAAAACCCTCATGAAGAAGGATAAGTACACTCTGCCTGGGGGCTTGCTGGCTCCTGGGGCCAACCCCATGACTTCTGGGGTAGGGGCCAGTCTGGGGGCCGGGGTCAATCAAAGGATGGACACTTATGCCCATATGAACGGCTGGACCAACGGGGGGTATGGCATGATGCAAGAGCAGCTCGGCTACCCCCAACACCCGGGCCTCAGCGCTCACAACGCGCCCCAGATGCAGCCCATGCACCGCTACGATGTCAGTGCCCTGCAATATAACTCCATGAGCAGCTCGCAGACTTACATGAACGGCTCGCCTACCTACAGCATGTCCTACTCCCAACAAGGGGCCCCGGGCATGTCCCTGGGATCCATGGGCTCTGTAGTCAAGTCGGAATCCAGCTCCAGTCCACCTGTAGTCACCTCTTCTTCCCATTCACGGGCTCCATGCCAGGCAGGGGACCTCCGGGACATGATCAGCATGTACCTACCTGGGGCAGAAGTGCCAGAGCCCGCAGCCCAAAGCAGACTGCACATGTCCCAACACTATCAGAGTGCCTCAGTAGCGGGCACAGCCATCAATGGCACGCTGCCTCTGTCGCACATGTGAAAGGCAATACTGAAGGAACTTTTATATCCAGAGCCTGGGCTAGAGGGGGACAAACTGTGGCCCTCCACCTGTTTCTGTACTACAGCTCCCAGTATCGTCTGTCTAGAGTGTCTGAGAGTTATAGTTCAGTAACAGCAGGAAGGCCAAAGGTTGGACCTCACTGTTCTGGACTCGTTTTTGGACTATTTTTGTACAGAAGAAAACAAAAATCTGGGGAGGGAAAAGGGAACTTGTATAGAACGAGAGAAAGGAGAGAAAAAAAGAGACAAAACATTGAAAATTCTAGGTAGGAACTTTGCAGAAAAGTTTGCAGACGCCCTTCCCAATACTATTAGCTCTAGTCTCACAGTGATGAGAAATCGTTTTATTATTTGCGACTTTTTTGTACAGTATTTATCAGATAAACAGGGCAGTCAGAATGGCCATTGTTTATAAGCTGCGACTTTGCCAATCTTTTTACAGTCATAGGTCAAGGAAGCCCCTCTAGAAAAAAGCTTTTCAATATGGGGGGAGGGGTACCAAATTTGGACAAGCGTAAACGTTTCAAAAATGTTCTCAAATTAACTACCATGCACCTGATATCCCATAATAACAAGCACAAGGCACAAGATGTACTTTTTCTTACAAAACCCCCATATTGTTAGAGTAAGAAATGGCCGCTATGATTCCAGCATTTGTTAATTTATATATCCGGCTGCTGTCCAACTCTTCCGATTTAAAAAAAAAAAAAAAGAAAGCAACGGAAACATGAATCTAATGTGTTTGAAATATTTTCTTATGGTTTGTAATATTTCTGTAAATTTATTGTGCTTATATTTTAAGTTTTTTTTTCTCTATCTCATTTTCAGTAGATGTATTTTAATGACTCGGCGCTGTATTATTTGGATCAGTTTGCCGAAAGTCCTTGTATATATATATATGAACTAATCCAACCCTAATAACAGGTACATTTTCAGCTTAAGTTTCTACACCATTATTCACAGTTTGAGATAAATAAATTTTTGAAATATGGAATCTGATATCAAAAAAAAAAAAAAAAAA	Refseq >NM_001088222\|Xenopus laevis SRY (sex determining region Y)-box 2 (sox2), mRNA CTGACAGCCCACATCACATGGACGGTTGTCTATTAACTTGTTTCAAAAAAGTAGCAGGACTTGTCACAAGCGCAGGGAGGGACAGCAGTTGGCTCAGCTGCCCGAGAGCAGAAACCGAGAGAGAGAGAGAGGCTGTGGCGGGAGAGAGAAAGTGAAGATAGTTTGGGAAACTGTGGGAAACTGATTCCGCTCTGCCAGCCTTTGCTCCCCACACGCCGCCTCGATGTACAGCATGATGGAGACCGAGCTCAAGCCCCCCGCCCCCCAGCAGCCATCGGGGGGCAACTCCAACTCTGCGTCCAACAACCAGAATAAGAACAGCCCGGACCGAGTGAAGAGACCCATGAACGCTTTCATGGTATGGTCCAGGGGCCAGAGGAGAAAGATGGCTCAGGAGAACCCCAAGATGCACAACTCGGAGATCAGCAAGAGGCTGGGGGCTGAGTGGAAGCTCCTCTCCGAGGCCGAGAAAAGACCCTTCATCGACGAGGCCAAGAGGCTGCGAGCTCTGCACATGAAGGAGCATCCGGATTATAAATACAGGCCCAGGAGGAAAACCAAAACCCTCATGAAGAAGGATAAGTACACTCTGCCCGGGGGCTTGCTGGCTCCTGGGGCCAACGCCATGACTTCTGGGGTCGGGGGCAGCCTGGGGGCCGGGGTCAACCAGAGGATGGACACTTATGCCCACATGAACGGCTGGACCAACGGGGGGTATGGCATGATGCAAGAGCAGCTTGGATACCCCCAACACCCGGGCCTCAACGCGCACAACGCGCCCCAGATGCAGCCCATGCACCGCTATGATGTCAGTGCCCTGCAATATAACTCCATGAGCAGCTCGCAGACTTACATGAACGGCTCGCCTACCTACAGCATGTCCTACTCCCAACAAGGGGCCCCGGGCATGTCTCTGGGATCCATGGGCTCGGTAGTCAAGTCGGAATCCAGCTCCAGTCCACCTGTAGTCACCTCTTCTTCCCATTCGCGGGCTCCGTGCCAGGCAGGGGACCTCCGGGACATGATCAGCATGTACCTACCTGGGGCAGAAGTGCCAGAGTCCGCAGCGCAAAGCAGACTGCACATGTCGCAACACTATCAGAGTGCCTCAGTAGCGGGCACAGGGATCAATGGCACGCTGCCTCTGTCGCACATGTGAAAAAGGGCATTACTGAAGAAACTTTATATCC
Protein		Refseq >NP_998869\|transcription factor Sox-2 [Xenopus (Silurana) tropicalis] MYNMMETDLKPPAPQQASGGNSNSGSNNQSKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGANPMTSGVGASLGAGVNQRMDTYAHMNGWTNGGYGMMQEQLGYPQHPGLSAHNAPQMQPMHRYDVSALQYNSMSSSQTYMNGSPTYSMSYSQQGAPGMSLGSMGSVVKSESSSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAQSRLHMSQHYQSASVAGTAINGTLPLSHM UniProtKB	Refseq >NP_001081691\|transcription factor Sox-2 [Xenopus laevis] MYSMMETELKPPAPQQPSGGNSNSASNNQNKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGANAMTSGVGGSLGAGVNQRMDTYAHMNGWTNGGYGMMQEQLGYPQHPGLNAHNAPQMQPMHRYDVSALQYNSMSSSQTYMNGSPTYSMSYSQQGAPGMSLGSMGSVVKSESSSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPESAAQSRLHMSQHYQSASVAGTGINGTLPLSHM UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.6201 [+] Str.53896	Xl.188
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		254 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SOX2	OMIM:206900
mouse		MGI	Sox2	All(21) Targeted, knock Out(4) Targeted, other(10) Radiation Induced(1)
zebrafish		ZFIN	sox2

Publications
First:		Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. [Development 1997]
Most recent:		The XenopusTGFBI is required for embryogenesis throughregulation of canonical Wnt signalling. [Dev Biol 2013]
		View All Papers 83 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding
Biological:		regulation of transcription, DNA-dependent
Cellular Component:
EC:
KOG:		[K] HMG-box transcription factor

Reagents		tropicalis	laevis
Clones		EXRC - 2 clone(s)	EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.43967.1.A1_at [+] Str.6201.1.S1_at	Xl.188.1.S1_at [+] Xl.6199.1.A1_x_at
Affymetrix 2.0			Xl2.188.1.S1_a_at [+] Xl2.188.1.S2_at Xl2.188.1.S2_a_at

Symbol legend[+]