Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (402) GO Terms (16) Nucleotides (515) Proteins (32) Interactants (2112) Wiki
XB-GENEPAGE- 484552

Gene Symbol: sox2

Gene Name: SRY-box 2

Synonyms: XLSOX-2 , Sox-2 , XSox2 , Xsox-2 , anop3 , mcops3
Add Xenopus synonyms , Nomenclature history

Gene Function: HMG-box transcription factor

Protein Function :
Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells resp...[+]


Interactants: Loading ...

Disease Ontology:
   MICROPHTHALMIA

OMIM Diseases:
   MICROPHTHALMIA, SYNDROMIC 3; MCOPS3 [+]
1/8
 

Xenbase Gene ID XB-GENE-484553 XB-GENE-17341038 XB-GENE-865099
Gene Symbol sox2 sox2.L sox2.S
Chromosome Chr05 Scaffold33547
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.6201 [+] Xl.188
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 419 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine sox2 sox2.L sox2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SOX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Sox2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR sox2 ZFIN Ensembl
chicken
GEISHA SOX2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Neural crest formation in Xenopus laevis: mechanisms of Xslug induction. [Dev Biol 1996]
Most recent: Cellular composition and organization of the spinal cord central canal during metamorphosis of the frog Xenopus laevis. [J Comp Neurol 2018]
View All Papers 138 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 11 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 16 terms 0 term 7 terms
PANTHER sox2
KEGG Pathways K16796 K16796
KOG [K] HMG-box transcription factor
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)   EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Sox2 Ab1 , Sox2 Ab2 , Sox2 Ab3 , Sox2 Ab5 , Sox2 Ab6 , Sox2 Ab7 Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab5 , Sox2 Ab6 , Sox2 Ab7
Morpholino sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5 sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5 sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5
ORF sox2 ORF1 , sox2 ORF1
Affymetrix 1.0 Str.43967.1.A1_at [+] Xl.188.1.S1_at [+]
Affymetrix 2.0 Xl2.188.1.S1_a_at [+]

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.1
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556