Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (473) GO Terms (25) Nucleotides (517) Proteins (34) Interactants (2475) Wiki
XB-GENEPAGE-484552
Gene Symbol: sox2

Gene Name: SRY-box 2

Synonyms: XLSOX-2 , Sox-2 , XSox2 , Xsox-2 , anop3 , mcops3 ( Add synonyms , Nomenclature history )

Gene Function: HMG-box transcription factor

Protein Function :
Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells resp...[+]


Interactants: Loading ...
Disease Ontology: microphthalmia

OMIM Diseases: MICROPHTHALMIA, SYNDROMIC 3; MCOPS3 [+]

1/8
 
Xenbase Gene ID XB-GENE-484553 XB-GENE-865099 XB-GENE-17341038
Gene Symbol sox2 sox2.L sox2.S
Chromosome Chr05 chr5L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model
Entrez Gene: 407873
Entrez Gene: 398000
mRNA RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine sox2 sox2.L sox2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SOX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Sox2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR sox2 ZFIN Ensembl
chicken
GEISHA SOX2 Ensembl
fruit fly
worm
WORMBASE
Publications
First Neural crest formation in Xenopus laevis: mechanisms of Xslug induction., Dev Biol 1996          
Most Recent Role of TrkA signaling during tadpole tail regeneration and early embryonic development in Xenopus laevis., Genes Cells 2020                  
All View All Papers 145 paper(s) referencing morpholinos 11 paper(s) referencing OMIMs 16 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 25 terms 6 terms 0 term
PANTHER sox2
KEGG Pathways K16796 K16796
KOG [K] HMG-box transcription factor
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)    
Horizon Horizon
Antibody Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab2 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8 Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8 Sox2 Ab5 , Sox2 Ab1 , Sox2 Ab3 , Sox2 Ab6 , Sox2 Ab7 , sox2 Ab8
Morpholino sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5 sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5 sox2 MO1 , sox2 MO2 , sox2 MO3 , sox2 MO4 , sox2 MO5
ORF sox2 ORF1
Affymetrix 1.0 Str.43967.1.A1_at [+] Xl.188.1.S1_at [+]
Affymetrix 2.0 Xl2.188.1.S1_a_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.3


Major funding for Xenbase is provided by grant P41 HD064556