Gene Symbol: opn4 Gene Name: opsin 4 Synonyms: opn4m, mammalian-like melanopsin, melanopsin Add Xenopus synonyms Gene Function: G protein-coupled receptor, photoreceptive opsin Interactants: rho(2) , clock(1) , crx(1) , pax6(1) , prox1(1) , rpa1(1) , rpe(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002937570|PREDICTED: Xenopus (Silurana) tropicalis melanopsin-A-like (LOC100491785), mRNA AAGAAAGCAAAGCAGTCATTCAGCCTATACTAGCCATTCAGTTGTGTTCTGGTGAAAAGAAGAAAAAACATGAATTATCAGTCTGTAAGAAAAGGCATCACCTGTCCTCCGCAAGATGCCAATTGCTCCAGGATACTGGAATCTTTAAACTCCTGGAATAACTCAGAAGTTAATTCTTATAAACTAGTGGAACTGCCACCAATTGTTACTACGGAAACACCTCAGTATGAGATTCACCATGTCTATCCGACGGTTGATGTTCCAGACCATGTGCATTATGTAGTTGGTGCTGTCATCCTTGCAGTGGGAATTACAGGCATGCTGGGAAATTTTCTAGTCATCTATGCTTTCTGCAGAAGTAGGAGCCTTCGATCTCCTGCAAATATGTTCATCATCAACCTAGCTATCACTGATTTCTTAATGTCTGTAACTCAGGCACCAGTATTTTTTGCAACTAGTCTGCATAAAAGATGGATCTTTGGAGAGAAAGGTTGCGAGCTATATGCTTTTTGTGGAGCCCTTTTTGGAATTACTTCCATGATCACACTGATGGTGATTGCTTTGGATAGGTATTTTGTGATCACACGACCACTCACCTCTATTGGTGTTATGTCCAAGAAAAGGGCAGTGCTAATCCTTTCAGGTGTTTGGCTGTATTCTCTGGCATGGAGTCTGCCTCCCTTCTTTGGTTGGAGTGCATATGTGCCCGAGGGTCTCCTGACATCCTGCACCTGGGATTATATGACCTTCACTCCATCTGTTCGAGCATATACCATGCTTCTCTTCTGTTTTGTTTTCTTCATTCCTCTTTTTATCATTATATATTGCTACATCTTTATCTTCAAGGCCATCAAAAATACAAACAGGGCAGTTCAGAAAATAGGCACAGATGACAATAAGGAATCTCATAAACAGTATCAGAAAATGAAGAATGAATGGAAAATGGCAAAAATTGCTCTGATTGTAATCCTCCTTTATGTTGTTTCATGGTCACCATATTCTACAGTGGCCCTTGTGGCCTTTGCAGGATATGCAAGTGTCTTAACACCATACATGAACTCTGTGCCGGCTGTGATTGCAAAAGCTTCTGCCATTCACAATCCTATCATCTATGCAATTACACATCCCAAATATCGGATGGCAATTGCAAAATATATTCCTTGCCTGGGATCATTGCTAAGAGTAAAACGCAGAGACTCCAGGTCCTACAGCAGTTACCCTTCTTCTCGGCGTTCCACTGTTACCAGCCACTGTAGCCAGTCCTCTGACGTGGGTGGGCATCCCAAGCTCAAAAATCATTTGCCAAGTGTCTCAGACAGTGAATCGGGCTGGACTGATACTGAAGCTGATAGTAGTGTGAACTCCAGACCAGCCAGTAGGCAGGTTTCCTATGAAATGGGCAAAGACACCACTGAGACCAATGATTTAAAATCCAAAGCTAAGCTGAAAAGTCATGATTCTGGAATTTTTGAGAAGACATCCATGGATGCAGATGATATTTCCTTGGTGGAACTTGGGACAGTTGATCGAAGTTCTCCCATTATGGCAAATAAACATTTGAACGGCCTGGGGCAAAGAAAGGGTGACTCTTTCACTAGACGATCCCCATCATCACGCATTCCAAGTATTGTTGTGACGCACAGCAACCACCAAGGGAGCCCAGCCGCAGTGAGGCATAATTCAACCTTGCCTGGTATTAAAGTCAGCAACAGTCAAGATCGAGAGAAGGAACTCAAAAGGCAAATAGAGAAAGTTAAGCAGTATGTGCCCATTGTGACCATCACCTCTGACACAGAAAATAGCACAGGAGGTTTTTCAAATGAATTACTACCTGCAAACACATCTTGA	NCBI Nucleotide >DQ384639|Xenopus laevis mammalian-like melanopsin (Opn4m) mRNA, partial cds GTGTGCATTATGTAGTTGGTGCTGTTATCCTTGCAGTAGGAATCACAGGCATGCTGGGAAATTTTCTAGTCATCTATGCTTTCTGCAGAAGTAGGAGTCTCCGATCTCCTGCAAATATGTTCATCATCAACCTTGCTATCACTGATTTCTTAATGTCGGTAACTCAGGCACCAGTATTTTTTGCAACTAGTCTGCATAAAAGATGGATCTTTGGAGAAAAAGGTTGCGAGTTATACGCTTTTTGCGGAGCCCTTTTTGGAATTACTTCCATGATCACACTGATGGTGATTGCTGTGGATAGATATTTTGTGATCACACGACCACTCACCTCCATTGGTGTTATGTCCAAGAAAAGGGCAGTGCTAATCCTTTCAGGTGTTTGGCTGTATTCTCTGGCATGGAGTCTTCCTCCATTCTTTGGTTGGAGTGCATATGTACCCGAGGGTCTTCTGACATCCTGCACCTGGGATTATATGACCTTTACTCCATCTGTTCGAGCATATACCATGCTTCTCTTCTGTTTTGTTTTCTTCATTCCACTTTTTATCATTATATACTGCTACATCTTTATCTTCAAGGCCATCAAGAATACAAACAGGGCAGTTCAGAAAATAGGTACAGATAACAACAAGGAATCTCACAAACAGTATCAGAAAATGAAGAATGAATGGAAAATGGCCAAAATTGCTTTGATTGTTATCCTCCTTTATGTTGTTTCATGGTCACCATATTCTACAGTGGCCCTACTGGCCTTTGCAGGATATGCAAGCATCTTAACACCATACATGAACTCTGTGCCTGCTGTGATTGCAAAAGCTTCTGCCATTCACAATCCTATCATATATGCTATTACACATCCCAAATATCGGATGGCAATTGCAAAATATATTCCTTGCCTGGGATCATTGCTGAGAGTAAAACGCAGAGACTCCAGATCCTT
Protein		NCBI Protein >XP_002937616|PREDICTED: melanopsin-A-like [Xenopus (Silurana) tropicalis] MNYQSVRKGITCPPQDANCSRILESLNSWNNSEVNSYKLVELPPIVTTETPQYEIHHVYPTVDVPDHVHYVVGAVILAVGITGMLGNFLVIYAFCRSRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEKGCELYAFCGALFGITSMITLMVIALDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGWSAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNRAVQKIGTDDNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALVAFAGYASVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYRMAIAKYIPCLGSLLRVKRRDSRSYSSYPSSRRSTVTSHCSQSSDVGGHPKLKNHLPSVSDSESGWTDTEADSSVNSRPASRQVSYEMGKDTTETNDLKSKAKLKSHDSGIFEKTSMDADDISLVELGTVDRSSPIMANKHLNGLGQRKGDSFTRRSPSSRIPSIVVTHSNHQGSPAAVRHNSTLPGIKVSNSQDREKELKRQIEKVKQYVPIVTITSDTENSTGGFSNELLPANTS	NCBI Protein >ABD37674|mammalian-like melanopsin [Xenopus laevis] VHYVVGAVILAVGITGMLGNFLVIYAFCRSRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEKGCELYAFCGALFGITSMITLMVIAVDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGWSAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNRAVQKIGTDNNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALLAFAGYASILTPYMNSVPAVIAKASAIHNPIIYAITHPKYRMAIAKYIPCLGSLLRVKRRDSRS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.57129
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	OPN4
mouse		MGI	Opn4	All(9) Targeted, knock Out(1) Targeted, other(7)
zebrafish		ZFIN	opn4.1

Publications
First:		Melanopsin: An opsin in melanophores, brain, and eye. [Proc Natl Acad Sci U S A 1998]
Most recent:		Isolation and characterization of melanopsin photoreceptors of Atlantic salmon (Salmo salar). [J Comp Neurol 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		rhodopsin-like receptor activity sphingomyelin phosphodiesterase activity
Biological:		G-protein coupled receptor protein signaling pathway visual perception
Cellular Component:		integral to membrane
EC:		sphingomyelin phosphodiesterase
KOG:		[T] G protein-coupled receptor

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.3431.1.S1_at
Affymetrix 2.0			Xl2Affx.39.1.S1_at [+] Xl2Affx.39.1.A1_at

Symbol legend[+]

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