Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (189) GO Terms (20) Nucleotides (564) Proteins (29) Interactants (1033) Wiki
XB-GENEPAGE- 484814

Gene Symbol: sox3

Gene Name: SRY-box 3

Synonyms: xSox3 , Sry , Xtsox3 , Xlsox3
Add Xenopus synonyms , Nomenclature history


Gene Function: HMG-box transcription factor

Protein Function:
Transcription factor with sequence-specific DNA binding activity. Binds to the consensus sequence 5'-[AT][AT]CAA[AT]G-3', showing a preference for 5'-AACAAT-3' and 5'-AACAAAG-3'. Inhibits beta-catenin-...[+]


Interactants: Loading ...

OMIM Disease Associations: MENTAL RETARDATION, X-LINKED, WITH PANHYPOPITUITARISM MENTAL... [+]
1/7
 
Xenbase Gene ID XB-GENE-484815 XB-GENE-17345032 XB-GENE-484819
Gene Symbol sox3 sox3.L sox3.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.27268 [+] Xl.22
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 189 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine sox3 sox3.L sox3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SOX3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Sox3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN sox3 ZFIN Ensembl
chicken
GEISHA SOX3 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Blastoderm-specific and read-through transcription of the sry alpha gene transformed into the Drosophila genome. [Dev Biol 1986]
Most recent: Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes. [Dev Biol 2017]
View All Papers 60 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 16 terms 0 term 15 terms
EC
PANTHER sox3
KEGG Pathways K09267 K09267
KOG [K] HMG-box transcription factor
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)    
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Sox3 Ab1 , Sox3 Ab2 Sox3 Ab1 , Sox3 Ab2
Morpholino sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4 sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4 sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4
ORF sox3 ORF1
Affymetrix 1.0 Str.27268.1.S1_at [+] Xl.22.1.S1_at
Affymetrix 2.0 Xl2.22.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556