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Summary Expression Gene Literature (1214) GO Terms (25) Nucleotides (588) Proteins (49) Interactants (1585) Wiki
XB-GENEPAGE-484814
Gene Symbol:
sox3

Gene Name:
SRY-box 3

Synonyms:
xSox3 , Sry , Xtsox3 , Xlsox3 ( Add synonyms , Nomenclature history )

Gene Function:
HMG-box transcription factor

Protein Function :
Transcription factor with sequence-specific DNA binding activity. Binds to the consensus sequence 5'-[AT][AT]CAA[AT]G-3', showing a preference for 5'-AACAAT-3' and 5'-AACAAAG-3'. Inhibits beta-catenin-...[+]


Antibodies: :
Sox3 Ab3

InterPro :
Znf C2H2 sf , Znf C2H2 type , SOX fam , HMG box dom sf [+]

Interactants:
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Diseases: 


Disease Ontology:
septooptic dysplasia [+]

OMIM:
MENTAL RETARDATION, X-LINKED, WITH PANHYPOPITUITARISM [+]

External Links:
1/7
 
Xenbase Gene ID XB-GENE-484815 XB-GENE-17345032 XB-GENE-484819
Gene Symbol sox3 sox3.L sox3.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493228
398329
399335
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine sox3 sox3.L sox3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SOX3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Sox3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Sox3 Ensembl
zebrafish
ZFIN, AGR sox3 ZFIN Ensembl
chicken
GEISHA SOX3 Ensembl
fruit fly
worm
Publications
First Blastoderm-specific and read-through transcription of the sry alpha gene transformed into the Drosophila genome., Dev Biol 1986  
Most Recent The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020                                                                                                
All View All Papers 63 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 8 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 22 terms 9 terms 11 terms
PANTHER sox3
KEGG Pathways K09267 K09267 K09267
KOG [K] HMG-box transcription factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks sox3
Mutants Xtr.sox3emHorb
Antibodies Sox3 Ab1 , Sox3 Ab2 , Sox3 Ab3 Sox3 Ab3 Sox3 Ab1 , Sox3 Ab2 , Sox3 Ab3
Morpholinos sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4 , sox3 MO5 sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4 , sox3 MO5 sox3 MO1 , sox3 MO2 , sox3 MO3 , sox3 MO4 , sox3 MO5
ORFs sox3 ORF1 MGC85087 ORF1 sox3.S ORF1
Clones EXRC Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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