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XB-GENEPAGE-
484854
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Gene Symbol: gli3
Gene Name: GLI family zinc finger 3 Synonyms: XGli-3 , Xgli3 Add Xenopus synonyms , Nomenclature history Gene Function: zinc finger, C2H2 type; hedgehog signaling Protein Function  :
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGG...[+]
Interactants: Loading ... 
Disease Ontology Associations: POLYDACTYLY OMIM Disease Associations: GLI-KRUPPEL FAMILY MEMBER 3; GLI3 |
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1/8 | Xenbase Gene ID | XB-GENE-484855 | XB-GENE-865509 | XB-GENE-17346222 | ||||
| Gene Symbol | gli3 | gli3.L | gli3.S | ||||
| Chromosome | Chr06 | chr6L | chr6S | ||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||
| Gene |
Genomic sequence
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Genomic sequence
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Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
NCBI Nucleotide
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Refseq
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NCBI Nucleotide
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| Protein
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TrEMBL |
Refseq
Swiss-Prot
TrEMBL
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NCBI Protein
TrEMBL
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| Genomic | tropicalis | laevis.L | laevis.S | ||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus | ||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||
| Ensembl | Ensembl | ||||||
| UniGene | Str.52711 | Xl.1041 [+] | |||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 53 expression image(s) for tropicalis and laevis | ||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||
| XenMine | gli3 | gli3.L | gli3.S | ||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||
| Smith Morpholino Screen | |||||||
| Orthology |
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| human |
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| mouse |
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| zebrafish |
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| chicken |
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| fruit fly |
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| worm |
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| Publications | |||||||
| First: | GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. [Mol Cell Biol 1990] | ||||||
| Most recent: |
Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear. [Dev Neurobiol 2017]
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| View All Papers 8 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontologies | |||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||
| GO | 6 terms | 12 terms | 6 terms | ||||
| PANTHER | gli3 | ||||||
| KEGG Pathways | K06230 | K06230 | |||||
| KOG |
[R] FOG: Zn-finger
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| Reagents | tropicalis | laevis.L | laevis.S | ||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||
| Clones | EXRC - 2 clone(s) | ||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||
| Source BioScience | Source BioScience | ||||||
| Morpholino | gli3 MO1 , gli3 MO2 , gli3 MO3 | gli3 MO1 , gli3 MO2 , gli3 MO3 | gli3 MO1 , gli3 MO2 , gli3 MO3 | ||||
| Affymetrix 1.0 | StrJgi.1039.1.S1_s_at [+] | Xl.1041.1.S1_at | |||||
| Affymetrix 2.0 | Xl2.1041.1.S1_at [+] | ||||||
Symbol legend[+]
