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Summary Expression Gene Literature (109) GO Terms (12) Nucleotides (91) Proteins (26) Interactants (487) Wiki
XB-GENEPAGE- 484854

Gene Symbol: gli3

Gene Name: GLI family zinc finger 3

Synonyms: XGli-3 , Xgli3
Add Xenopus synonyms , Nomenclature history


Gene Function: zinc finger, C2H2 type; hedgehog signaling

Protein Function:
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGG...[+]


Interactants: Loading ...

OMIM Disease Associations: ACROCALLOSAL SYNDROME; ACLS [+]
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Xenbase Gene ID XB-GENE-484855 XB-GENE-865509 XB-GENE-17346222
Gene Symbol gli3 gli3.L gli3.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq NCBI Nucleotide
Protein Refseq Swiss-Prot TrEMBL NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.52711 Xl.1041 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 53 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine gli3 gli3.L gli3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards GLI3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Gli3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN gli3 ZFIN Ensembl
chicken
GEISHA GLI3 Ensembl
fruit fly
worm
WORMBASE
Publications
First: GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. [Mol Cell Biol 1990]
Most recent: Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear. [Dev Neurobiol 2017]
View All Papers 8 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 12 terms 6 terms
EC
PANTHER gli3
KEGG Pathways K06230 K06230
KOG [R] FOG: Zn-finger
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino gli3 MO1 , gli3 MO2 gli3 MO1 , gli3 MO2 gli3 MO1 , gli3 MO2
Affymetrix 1.0 StrJgi.1039.1.S1_s_at [+] Xl.1041.1.S1_at
Affymetrix 2.0 Xl2.1041.1.S1_at [+]

Symbol legend[+]

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