Gene Symbol: akt1 Gene Name: v-akt murine thymoma viral oncogene homolog 1 Synonyms: protein kinase B, xAct, pkb, v-akt, v-akt1, AKT, akt-1 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: ptk2b(29) , sgk1(25) , ins(22) , mapk1(22) , pik3ca(22) , pik3cb(13) , pik3cg(13) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002940717|PREDICTED: Xenopus (Silurana) tropicalis RAC-alpha serine/threonine-protein kinase-like (LOC100490038), mRNA AGACAGCGGCTGGAGAAAGGAAGAGAAGGCAGGAGGGAGGATCGCTTTGGGCAGGGGAGGAAGAGCCATTGCTCACTGTGTGCAGGGGAGGAAGAGACAGAGACGGGCACACACACAGCTGATGCACAGGAGAATGATCCGAGGCTGAAGACTGCAGAGCCGAGGCAGTTATCCTGCAAGCGGCAGCAGTACCCACATCCCAGGGTGGCAGCAAGGTGACAGCAGCAGCAGCAGCACTACTCTCCTGCCAACCATCAGCAGCAGCCGGTTCCTCCCATCCCTCCATGCAATCAATGGGCTGAATCTGCAGCAGCAGCAACACTACAAGCAAAAGCAGCCTTATCCTTCCCCACCTCCTCCTCCCACCCTCTCCCCCTCTGTGTCTGCTCTCCTCTCCTCCCTTCTTTCCTCTCCCTTCCCTCTCCTGCTCCCCTCGGTGATGGTGAGGCTTCAGCTGGCTGTAATCCACCGCTAGGCCCCAAGCCCCCCTCCCAACTCGGTGGCTGCCCTCCTCTTCCAGACTCAGCTCATTAATACCTCTTGCATCCATAAATCCTAAAATTTTGCTGCTACAGTTTTAAGTCCACATCTAAGTGAGTGTTGCAGGCAAGTGTACATTGCCGTCATGAATGAAGTAAGCATTGTGAAGGAAGGTTGGCTGCACAAAAGAGGTGAATACATCAAGACCTGGCGTCCCCGCTACTTCCTCCTCAAAACTGACGGTACTTTCATTGGGTACAAAGAGCGTCCACAGGATGTTGACCAGTTGGAAACTCCTTTAAATAATTTCTCTGTAGCCAAATGTCAGCTGATGAAGACAGAACGACCAAAACCAAACACATTTATCATTCGGTGCCTCCAGTGGACCACAGTAATTGAAAGAACATTTCATGTGGATTCTCCTGAGGAGCGGGAAGAATGGATTCAGGTTATACAACATGTAGCCGACAACCTTAAGAAACAGGAAGAAGAAATGATGGAGGTTCGGTCTGGCGACTCCCCAAGCGATAACTCTGGAGCCGAGGAAATGGAAGTTTCTCATTCGAAACCAAAACATAAAGTAACAATGAATGAATTTGAGTATCTCAAGCTTTTGGGGAAAGGAACATTTGGGAAAGTTATTTTAGTCAAAGAGAAAGCAACAGGAAGATATTACGCTATGAAAATTTTAAAAAAAGAAGTTATTGTTGCAAAGGATGAAGTAGCTCACACGCTAACAGAAAACCGCGTCCTGCAGAATTCTAGGCATCCCTTCCTAACAGCACTGAAATATTCCTTTCAGACACATGATCGCTTATGTTTTGTCATGGAGTATGCCAATGGAGGAGAGTTATTCTTCCACTTATCAAGAGAACGTATATTCTCTGAAGATCGTGCCCGGTTTTATGGGGCAGAGATTGTTTCTGCTTTAGATTATCTTCATTCTGAGAAAAATGTAGTTTACAGAGACTTAAAGTTGGAAAATCTAATGCTGGACAAAGATGGACACATAAAGATAACTGATTTTGGCCTGTGCAAGGAAGGAATAAAAGACGGAGCAACCATGAAGACGTTCTGTGGCACACCAGAATATCTCGCTCCTGAGGTGCTAGAAGATAATGACTATGGCCGTGCTGTAGACTGGTGGGGCTTGGGCGTAGTGATGTACGAGATGATGTGTGGGCGCCTCCCTTTCTACAATCAAGACCATGAAAAATTGTTTGAACTTATCCTTATGGAAGAGATTAGATTTCCACGCACTTTATTGCCAGAAGCAAAGTCTTTGCTGTCTGGTTTGTTGAAGAAGGACCCTAAGCAAAGGTTAGGCGGCGGGCCAGACGATGCTAAAGAAATCATGCAACACAAATTTTTTGCTGGAATTGTATGGCAAGATGTTTATGAGAAGAAGCTTATACCTCCATTTAAGCCACAAGTAACGTCAGAAACAGACACAAGGTATTTTGATGAGGAATTCACAGCGCAAATGATCACCATAACACCACCTGACCAAGATGACAATTTAGAATTTGTTGACAACGAGAGAAGACCGCACTTCCCCCAGTTTTCATACTCTGCTAGTGGAAATGCTTAGCTCCTCGGCAACTGTCTCTTTTCCATTGCAACACAGACATCATTTTGGGGCACCTAAGATCATCAGACTTTGTACAGGACTTTCAATAGCCTATGAATTACAAACTATGTTTGTATGACCATAAAGAAGGATTTAGAGAATGTCTGAAAATGAAGTCTGTATGTGAACCAGTTCTCTCATTTCACATTTACAAAGAAACCCAGGCCATCCTTGAAAGATTTCTCATGTATGTATGGCAGTACATACATATGTCAACGTTAATATTATGTGTCGGATGATTCCACACAGGCTGAGAATGTGCTCATCACCTATCAACTGAACAAATGAAGAGTGAGCATATCATAAATTAAAATAAAGTTAATATCTTCATGCCCGCCCTGGTTATCCCACAACATC	Refseq >NM_001090409|Xenopus laevis v-akt murine thymoma viral oncogene homolog 1 (akt1), mRNA ATGAATGAAGTAGCGATAGTGAAGGAAGGCTGGCTGCACAAAAGAGGTGAATACATAAAGACCTGGCGTCCCCGCTACTTCCTCCTCAAATCTGACGGTACTTTCATTGGGTACAAAGAGCGTCCACAAGATGTTGACCAGTTGGAAACTCCTTTAAATAATTTCTCTGTAGCCAAATGTCAGCTGATGAAGACAGAACGACCAAAACCAAACACATTTATCATTCGGTGCCTCCAGTGGACCACAGTAATTGAAAGAACATTTCATGTGGATTCTCCAGAGGAGCGGGAAGAATGGATTCAGGTGATACAACATGTAGCCGACAACCTCAAGAAGCAGGAAGAAGAAATGATGGAGGTTCGGTCCGGCGACTCGCCAAGTGATAATTCTGGAGCTGAGGAAATGGAAGTTTCTCATTCGAAACCAAAACATAAAGTTACAATGAATGAATTTGAGTATCTCAAGCTTTTGGGGAAAGGAACGTTTGGAAAAGTTATTTTAGTAAAAGAGAAAGCAACAGGACGATATTACGCTATGAAAATTTTAAAAAAAGAAGTTATTGTTGCAAAGGATGAAGTAGCCCACACGCTTACGGAAAACCGCGTCCTACAGAATTCTAGGCATCCCTTCCTAACAGCATTAAAATATTCTTTTCAGACTCATGATCGCTTATGTTTTGTGATGGAGTATGCCAATGGAGGAGAGTTATTCTTCCACTTATCAAGAGAACGTATATTCTCTGAAGATCGTGCCCGGTTTTATGGGGCAGAGATTGTTTCTGCTTTAGATTATCTTCATTCTGAGAAAAATGTAGTTTACAGAGACTTGAAGTTGGAAAATCTAATGCTGGACAAAGACGGACACATAAAGATAACAGATTTTGGACTGTGCAAAGAAGGAATAAAAGATGGAGCAACCATGAAGACCTTCTGTGGAACACCAGAATATCTTGCTCCTGAGGTGCTAGAAGATAATGACTATGGTCGTGCTGTAGACTGGTGGGGCTTGGGCGTAGTGATGTACGAGATGATGTGCGGGCGCCTCCCTTTCTACAATCAGGACCATGAAAAATTGTTTGAACTTATTCTTATGGAAGAAATTAGATTCCCACGCACTTTATTGCCAGAAGCCAAGTCTTTGCTGTCTGGTTTGTTGAAGAAGGACCCTAAGCAAAGGTTAGGTGGTGGGCCAGACGATGCAAAAGAAATCATGCAACACAAATTTTTTGCTGGAATAGTATGGCAAGATGTTTATGAGAAGAAGCTTGTTCCCCCATTTAAGCCACAAGTAACGTCAGAAACAGACACAAGGTATTTTGATGAAGAATTCACAGCGCAGATGATCACCATCACACCACCTGACCAAGATGACAATTTCGAATTTGTAGACAACGAGAGGCGGCCGCACTTCCCCCAGTTTTCATACTCTGCTAGTGGAAATGCTTAGCTCTTCAGCAACGGTTTCTTTTCCATTGCAACACAGACATCAATTTTTGGGGCACCTAAGATCATCAGACTTTGTACAGGACTTTCAATAGCCTACGAGTTACAAACTATGTTTGTATGACCATAAAGAAGGAGTTAAAAGAATGTCTGAAAATGAAGTCTGTATGTGAACCAGTTCTCTCATTACACATCTGAACCCTTGAAAGCTTTCTCACGTACGTATCGTAGGACATACACGCGGCAACGGTCATATCATGTGGCGGATGATTCCACGCAGTCTGAGAATGTGCTCATCAGCCGAACAAATGAAGAGTGAGCATATCATAAATTCCAAAAAAAATGAATATCTTCGGTTATCCCACG
Protein		NCBI Protein >XP_002940763|PREDICTED: RAC-alpha serine/threonine-protein kinase-like [Xenopus (Silurana) tropicalis] MNEVSIVKEGWLHKRGEYIKTWRPRYFLLKTDGTFIGYKERPQDVDQLETPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDSPEEREEWIQVIQHVADNLKKQEEEMMEVRSGDSPSDNSGAEEMEVSHSKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLLPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKFFAGIVWQDVYEKKLIPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNLEFVDNERRPHFPQFSYSASGNA	Refseq >NP_001083878|RAC-alpha serine/threonine-protein kinase [Xenopus laevis] MNEVAIVKEGWLHKRGEYIKTWRPRYFLLKSDGTFIGYKERPQDVDQLETPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDSPEEREEWIQVIQHVADNLKKQEEEMMEVRSGDSPSDNSGAEEMEVSHSKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLLPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKFFAGIVWQDVYEKKLVPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNFEFVDNERRPHFPQFSYSASGNA UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.738 [+] Xl.9191
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	AKT1	OMIM:114500 OMIM:114480 OMIM:181500 OMIM:604370
mouse		MGI	Akt1	All(10) Targeted, knock Out(3) Targeted, other(4) Gene Trapped(1)
zebrafish

Publications
First:		Pharmacological profile of NPC 17742 [2R,4R,5S-(2-amino-4,5-(1, 2-cyclohexyl)-7-phosphonoheptanoic acid)], a potent, selective and competitive N-methyl-D-aspartate receptor antagonist. [J Pharmacol Exp Ther 1993]
Most recent:		Up-Regulation of the Inwardly Rectifying K(+) Channel Kir2.1 (KCNJ2) by Protein Kinase B (PKB/Akt) and PIKfyve. [J Membr Biol 2013]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		ATP binding protein kinase activity protein serine/threonine kinase activity More[+] protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:
KOG:		[T] Serine/threonine protein kinase (alt_id KOG:0690)

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		Str.18949.3.S1_at [+] Str.21690.1.S1_at	Xl.738.1.S1_at
Affymetrix 2.0			Xl2.738.1.A1_at

Symbol legend[+]

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