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Summary Expression Gene Literature (47) GO Terms (28) Nucleotides (102) Proteins (40) Interactants (479) Wiki
XB-GENEPAGE-485116
Gene Symbol:
lrp5

Gene Name:
LDL receptor related protein 5

Synonyms:
Xlrp5 , hbm , lr3 , ops , evr1 , evr4 , lrp7 , oppg , bmnd1 , opta1 , vbch2 ( Add synonyms , Nomenclature history )

Gene Function:
Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains

Protein Function :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
exudative vitreoretinopathy [+]

OMIM:
OSTEOPOROSIS [+]

External Links:
 
Xenbase Gene ID XB-GENE-485117 XB-GENE-864864 XB-GENE-17341722
Gene Symbol lrp5 lrp5.L lrp5.S
Chromosome Chr4 chr4L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100491803
373722
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine lrp5 lrp5.L lrp5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LRP5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lrp5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lrp5 Ensembl
zebrafish
ZFIN, AGR lrp5 ZFIN Ensembl
chicken
GEISHA LRP5 Ensembl
fruit fly
worm
Publications
First Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung., Gene 1998  
Most Recent Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner., Elife 2018                        
All View All Papers 5 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 28 terms 8 terms 0 term
PANTHER lrp5
KEGG Pathways K03068 K03068
KOG [T] Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lrp5
Antibodies Lrp5 Ab1 Lrp5 Ab1 Lrp5 Ab1
Morpholinos lrp5 MO1 lrp5 MO1 lrp5 MO1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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