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Summary Expression Gene Literature (46) GO Terms (7) Nucleotides (85) Proteins (31) Interactants (352) Wiki
XB-GENEPAGE- 485116

Gene Symbol: lrp5

Gene Name: LDL receptor related protein 5

Synonyms: Xlrp5 , hbm , lr3 , ops , evr1 , evr4 , lrp7 , oppg , bmnd1 , opta1 , vbch2
Add Xenopus synonyms , Nomenclature history


Gene Function: Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains

Protein Function:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.


Interactants: Loading ...

OMIM Disease Associations: OSTEOPOROSIS [+]
 
Xenbase Gene ID XB-GENE-485117 XB-GENE-864864 XB-GENE-17341722
Gene Symbol lrp5 lrp5.L lrp5.S
Chromosome Chr04 chr4L
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.23625 Xl.20920
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 3 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine lrp5 lrp5.L lrp5.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards LRP5 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Lrp5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN lrp5 ZFIN Ensembl
chicken
GEISHA LRP5 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. [Gene 1998]
Most recent: Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. [Dev Cell 2017]
View All Papers 5 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 7 terms 0 term
EC
PANTHER lrp5
KEGG Pathways K03068
KOG [T] Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Lrp5 Ab1 Lrp5 Ab1 Lrp5 Ab1
Morpholino lrp5 MO1 lrp5 MO1 lrp5 MO1
Affymetrix 1.0 Str.42539.1.S1_s_at [+] Xl.20920.1.S1_at
Affymetrix 2.0 Xl2.20920.1.S1_at

Symbol legend[+]

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