otx2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (259)

Nucleotides (264)

Interactants (561)

XB-GENEPAGE-485219

Gene Symbol: otx2 Gene Name: orthodenticle homeobox 2 Synonyms: Xotx2, otx-2, Xotx-2 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: en2(68) , egr2(66) , chrd(63) , t(58) , gsc(53) , pax6(50) , bmp4(48) View All	1/5

XB-GENE-485220

XB-GENE-6254039

XB-GENE-485224

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001016177\|Xenopus (Silurana) tropicalis orthodenticle homeobox 2 (otx2), mRNA CTTGTAGACCATTGTGTGCAAAGGAAGAGCGGGATCAAGAAGCACACACTACACTGATCGCCCGACTTGCTGCAACGATTTTCTGATTTTCTTTCGCGGATTGTGCTCCCTGATAAAACACTAGCATGATGTCTTATCTCAAGCAACCGCCATATGCCGTGAATGGGCTCAGCCTGACTACCTCCGGGATGGATTTGTTACATCCGTCGGTGGGATATCCCGCGACCCCCAGGAAACAGAGGAGGGAAAGGACCACTTTCACCAGAGCCCAACTGGATGTCCTCGAAGCACTTTTTGCCAAAACTCGTTACCCCGATATCTTCATGAGAGAAGAAGTGGCTCTAAAAATCAACTTGCCGGAGTCCAGAGTCCAGGTTTGGTTCAAAAACCGCCGAGCCAAGTGCCGGCAGCAGCAACAGCAGCAGCAGAATGGGGGGCAAAACAAAGTGAGACCCTCTAAGAAGAAGCCCTCCCCGGCCAGGGAAGTGAGCTCTGAGAGCGGCACCAGCGGCCAGTTCAGCCCCCCCTGCAGCACCTCAGTTCCAGTCATATCGAGCAGCACAGCCCCTGTGTCCATCTGGAGCCCGGCCTCCATCTCTCCCCTCTCAGACCCACTCTCCACATCATCCTCATGCATGCAGAGGTCTTACCCCATGACCTACACACAGGCATCAGGCTACAGCCAGGGATATGCAGGCTCTACATCCTACTTTGGGGGCATGGACTGTGGATCTTACTTGACCCCAATGCACCATCAACTCTCTGGAGCTGGGGCTACTCTCAGCCCAATGGGCACCAACGCAGTGACAAGCCACCTTAACCAGTCCCCAGCTGCCCTCTCTTCCCAGGCCTATGGGGCCTCTAGCTTGGGTTTTAACTCCACCGCTGACTGCCTGGATTACAAAGACCAAACGGCCTCCTGGAAGCTGAACTTCAATGCTGACTGCTTGGATTATAAAGACCAAACCTCTTCATGGAAGTTCCAGGTTTTGTGAAGAACTTTCCCCTCTCCCTCTCTATCTGCGTCAGGTGGAAAACTTTGCTGAGACATTCCCAGCTCTGGCCCAGTCTGGTTGAACAAGTAGGAAGCAAAACACACAAAGACCATTTATTTCATCCACATAGAACCCTGGGCTGACTGGCTCTGGACTGGATCTGGAGACATCTCCATGCAATGGGAAAACAAAGGACACATCTCTATCCAGTGACCAGGAACCACATGAAGTCTTTATCTTGTTAGATTTTAGCAGGTGGATGAAAGATGGAGAAGAACTAAGTGCAGCTGAGCAGCACAGGAGCCAGGCTGCAGAGTAATTTGGGGCTGTGTGTGTATTGGCTGCAGACTCAAGCTCTGCTCTTTCATGGCTGCCTTCTGGCTTAGAAAGAACATTTCAGGATTTGAGTGAATTGTGCAACTGATTGTCCTAGATGCACTACTTTATTTAAAGAAAACAAATTAATAATAATGTTTATAAGAAGTCATTATGTAGTTTTTAAAAGACAATCAGTGTGTGTCTTATATAAATGGTAAATCTGTGGTTTTTAATCTGTGCTAGACATCAAAACTGTGATCTCTTGTATTGTATGCAACTGTGAACTCCACACCAGCGGGGGGTCGTACTGTGATTTAATAACAGGTTTATTATTAGCAGGAAGATTCAGGATTTAGCGCAAAACCGATGCCCCTTAATATTATTCAAAGCGAGCGAATGGGGCCTCTAAGGAACTGCGGTTAAACCTTTCTTTTCCTCCACCAACTCCTCCTGAGTTTATTTTATATTCGACCCCGCAACGAACGCAGGGACCGGAATCCGCAATATAGAAAGGAACAGGACAGAGGATTATTTAATAACTAAAGGACTTGTCTGTTGTCACTGACCCTGATATATTCATTGCAAGAAGGAATCCCTTATGCGTTTATGCTTGCCTTTGTGAATTAAGATATAAATATATATATATACACACCATAAACCTTTTCCCCTGGATCTGGCAAATATGTATAAAAAATTTATTAAATGACTCTAGCACAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090691\|Xenopus laevis orthodenticle homeobox 2 (otx2-a), mRNA GCCATCGGACATAAAGCAGCTCATCATTTAATCACATTTCTGTCCACTTGTAGAAAATTGTGCGCAAAAAAAAATAAGAAAAAACGCCCAACGGATCCAGCAAACACTGATCGCCCGACTTTGTCGCTGCAACGATTTCTTCCGCGGATTGTGCTCCCTGATCAAACACGAGCATGATGTCTTATCTCAAGCAACCGCCATACGCCGTGAATGGGCTCAGCCTGACCGCCTCCGGGATGGATTTGTTGCACCAGTCGGTGGGATATCCCGCGACCCCCAGGAAACAGAGGAGGGAAAGGACCACTTTTACCAGGGCCCAACTGGATATCCTTGAAGCACTTTTTGCCAAAACTCGTTACCCTGATATCTTCATGAGAGAAGAAGTGGCTCTAAAAATCAACCTACCTGAGTCCAGAGTCCAGGTCTGGTTCAAAAACCGCAGAGCAAAGTGCCGGCAGCAGCAACAGCAGCAGCAGAATGGAGGCCAAAACAAAGTGAGACCTTCTAAGAAGAAGACCTCTCCTGTTAGAGAAGTGAGCTCGGAGAGTGGCACCAGCGGCCAATTCAGCCCACCTAGCAGCACGTCTGTTCCAGTCATCTCAAGCAGCACAGCCCCTGTGTCCATCTGGAGCCCGGCCTCCGTCTCTCCTCTGTCCGACCCCCTATCCACATCATCTTCATGTATGCAGAGGTCCTACCCTATGACCTACACGCAGGCATCAGGGTACAGCCAAGGATATGCAGGCTCAACATCCTACTTTGGGGGTATGGACTGTGGATCTTACTTGAGCCCTATGCATCATCAGCTCTCTGGACCTGGAGCTACTTTAAGCCCAATGGGCACCAATGCAGTGACAAGTCACCTTAACCAGTCCCCAGTTGCCCTCTCCTCACAGGCCTATGGAGCTTCTAGCTTGGGTTTTAATTCCACTGACTGCCTGGATTACAAAGACCAAACTGCCTCCTGGAAGCTGAACTTCAATGCTGACTGCTTGGATTATAAAGACCAAACCTCATCTTGGAAATTCCAGGTTTTGTGAAGAACTTTCCTCTCTCTCTCTGTGTCAGGTGGAGAACTTTCCTGAGACATGACCAGCTCGGGCCAAACCTCATCTTGGAAGTTCCAGGTTTTATGAAGAACTTTCCCTCTCTCTCTGTGTCAGGTGGAGAACTTTGCTGAGACATTCCTAGCAATGGCCAAACCTCATCTTGGAAGTTCCAGGTTTTGTTAAGAACGTTCTCTCTCTCTGTGTCAGGTGGAGAACTTTGCTGAGACATATCCAGCTCTGGCCAAGTCTGGTTGGAAGAAGCAATAAGCAAAACAACACAAAGACCATTTATTTTACCCACACAGAACCCTGGTCTAAGCTCTGGACTAGATCTGAAGACCTCTCCATGCAATGGAAAAAAGGACATTTTTTATCCAGTGACCAAGAGCCACACTAAGTCCTTATCTTGTTACATTTTAGCAGGTGGATAAAAGATGGAGAAGAAATCAGTCCAACACAGGAGCACAGGACCCATAAGCTATGGACCAGGCTGTAGAGCAATTTGGGGTTGGTTTATGTGTGTATGTTGGCTGGAGACTCAAACTCTGCTCTTTCATGGCTAAGAAAGAACATTTCAGGATCTGAGTGAATTGTGCAACGGATTGTCCAAGATGCACTATTTTATTTAAAGAAAACAAATTAATAATGTTTATAAGAATCCATTATGTAGTTTTTAAAACAAGACAAAAAAAAAAAAAAA		Refseq >NM_001091486\|Xenopus laevis orthodenticle homeobox 2 (otx2-b), mRNA GGCTTCTTAAATAGCTCGTGCATTGGCTGTCCAAGCTCACATACTAACAAGCCACCAGACATAAAGGAGCTCGCTTAGGCACCTCATCGGTTAATCCCGTTTCTGTCCACTTGTAGAAAATACAGTGCAAAAAGAAAGAGCAGGCAACTGATCGTGCGACTTGCTGCTGCTGCAACGATTTCCTTCGCGGATTGTGCTCCCTGATCAAACACTAGCATGATGTCTTATCTCAAGCAACCGCCATATGCCGTGAATGGGCTCAGCCTGACTACCTCTGGGATGGATTTGTTACATCCGTCGGTGGGATATCCCGCGACCCCCAGGAAACAGAGGAGGGAAAGGACCACTTTCACCAGAGCTCAACTGGATATCCTCGAAGCACTTTTTGCCAAAACTCGCTACCCTGATATCTTCATGAGAGAGGAAGTGGCTCTAAAAATCAACCTACCCGAGTCCAGAGTCCAGGTTTGGTTCAAAAACCGCCGAGCAAAGTGCCGCCAGCAGCAACAGCAGCAGCAGAATGGAGGCCAAAACAAAGTGCGACCTTCTAAGAAGAAGACCTCCCCGGCCAGGGAAGTGAGCTCGGAGAGTGGGACCAGCGGCCAGTTCAGCCCACCTTGCAGCACCTCTGGTCCAGTCATCTCGAGCAGCACAGCCCCTGTGTCCATCTGGAGCCCGGCCTCCATCTCTCCTCTCTCAGATCCACTCTCCACATCATCTTCATGCATGCAGAGGTCCTACCCCATGACCTACACGCAAGCATCAGGCTACAGTCAAGGATATGCAAGCTCTACATCCTACTTTGGGGGTATGGACTGTGGATCTTACTTGACCCCTATGCACCATCAGCTCTCTGGACCTGGAGCTACTCTAAGCCCAATGAGCACCAACGCAGTGACAAGTCACCTTAACCAGTCCCAAGCTGCCCTCTCCTCACAGGCCTATGGGGCTTCTAGCTTGGGTTTTAACTCCACCGCTGACTGCCTGGATTACAAAGACCAAACGGCCTCCTGGAAGCTGAACTTCAATGCTGACTGCTTGGATTATAAAGACCAAACCTCCTCTTGGAAGTTCCAGGTTTTGTGAAGAACTTTCCTTCTCTAACTGTGTCAGGTGGAAAACTTTGCTGAGACATTCCCAGCTCTGACCAAGTCTGGTTGAACAAGTAAAAGTAAAAACTACACACAGACCATTTATTTTACCCACACAGAACCCTGGTCTTACTCAGCTCTGGACTGGATCTGGAGACATCTCCATGCAATGGGGGGAAAAAGGACATATCTTTATCCAGTGACCAAGAGCCACATCAAGTCCTTATCTTGTTATTAGATATTAGCAGGTGGATGAAAGATGGAGAAGAAATAAGTCCAACCCAACTCCAGCAGCACAGGACCCATAAGCTGTGGGCCAAGCCCAGGCTGCAGAGCAATTTGGGTTTGGTGTGTGTGTATTGGCTGGAGACTCAAGCTCTGCTCTTTCACCTTCTGGCTTAGAAAGAACATTTCAGGATCTGAGTGAATCGTGCAACTGATTGTCCTAAATGCACTACTTTATTTAAAGAAAACAAATTAATAATTATGTTTATAAGAAGTCATGATGTAGTTTTTAAAAGACAATCAGTGTGTGTCTTATATCAATGGTAAATCTGTGGTTTTTAATCTGTGCTAGACTTCAAAACTGTGATCTCTTGTATTGTATGCAACTGTGAACTCCACACCAGCGGGGAGGGGGGGGGGTCGTACTGTGATTTAATAACAGGTTTTATTATTAGCAGGAAGATTCAGGATTTAGCGCAAAACCGATGCCCTTTAATGTTATTCCGAGCGAGCGCATGGGCCTGTAAAGAACTGCAGTTAAACCTTTCTTTTCCTCGACCAATTCCTCTTGAGTTGATTTTATATTCGACCCGGCAACGAACGCAGGGACTGGAAGCCGCAATATAGAAAGGAACAGGACAGACGATTATTTAATAACTAAAAGACTTTTTTTTTTGTCACTGACCTTGAGATATTAATTGCGACAAGGAATCCCATATGCGTTTATGCTTGCCTTTGTGAATTAAGATATAAATATATATATACACACCCATAATCCTTTCCCCCTGGATCTGGCAAATATGTATAAAAAAAAATCTATTAAATGACTCTAGCACAAACAACTGTCTTCCATTTTCATTTTCATACACCAGCTGTTTGGGTGGAGGTGGCTATGAAAGACTTGCTGAGTTTTTCTTTGGACATAGAAATACTTTCAAGGGGTCCTCCGCCTAAAAACTGCATAATAAAAAGTTGTGAAACATAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001016177\|homeobox protein OTX2 [Xenopus (Silurana) tropicalis] MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPSKKKPSPAREVSSESGTSGQFSPPCSTSVPVISSSTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGAGATLSPMGTNAVTSHLNQSPAALSSQAYGASSLGFNSTADCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL UniProtKB	Refseq >NP_001084160\|homeobox protein OTX2-A [Xenopus laevis] MMSYLKQPPYAVNGLSLTASGMDLLHQSVGYPATPRKQRRERTTFTRAQLDILEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPSKKKTSPVREVSSESGTSGQFSPPSSTSVPVISSSTAPVSIWSPASVSPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLSPMHHQLSGPGATLSPMGTNAVTSHLNQSPVALSSQAYGASSLGFNSTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL UniProtKB		Refseq >NP_001084955\|homeobox protein OTX2-B [Xenopus laevis] MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDILEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPSKKKTSPAREVSSESGTSGQFSPPCSTSGPVISSSTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYASSTSYFGGMDCGSYLTPMHHQLSGPGATLSPMSTNAVTSHLNQSQAALSSQAYGASSLGFNSTADCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.10021 [+] Str.40314	Xl.3004		Xl.47281
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		188 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis a		laevis b
Smith Morpholino Screen		tgas114a06

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	OTX2	OMIM:610125
mouse		MGI	Otx2	All(33) Targeted, knock Out(11) Targeted, other(21)
zebrafish		ZFIN	otx2	3 Lines(s)

Publications
First:		The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. [Development 1995]
Most recent:		The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo. [Dev Biol 2013]
		View All Papers 67 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		multicellular organismal development regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Homeobox transcription factor

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 2 clone(s)	EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.10021.1.S1_at [+] Str.26130.1.A1_x_at Str.26130.1.A1_at	Xl.1268.1.S1_at		XlAffx.1.11.S1_at [+] Xl.11672.1.A1_at Xl.3004.1.A1_at
Affymetrix 2.0			Xl2.3004.1.S1_at		Xl2.47281.1.S1_at

Symbol legend[+]