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Summary Expression Gene Literature (530) GO Terms (12) Nucleotides (296) Proteins (53) Interactants (2455) Wiki
XB-GENEPAGE-485219
Gene Symbol:
otx2

Gene Name:
orthodenticle homeobox 2

Synonyms:
Xotx2 , otx-2 , Xotx-2 , otxA , otx2-a , otx2-b ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer ...[+]


InterPro :
TTL/TTLL fam , ATP grasp subdomain 1 , TTLL12 , Homeobox dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
septooptic dysplasia [+]

OMIM:
MICROPHTHALMIA, SYNDROMIC 5; MCOPS5 [+]

External Links:
1/6
 
Xenbase Gene ID XB-GENE-485220 XB-GENE-485224 XB-GENE-6254039
Gene Symbol otx2 otx2.L otx2.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 548931
432013
399342
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine otx2 otx2.L otx2.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tgas114a06      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards OTX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Otx2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Otx2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR otx2b otx2a ZFIN Ensembl
chicken
GEISHA OTX2 Ensembl
fruit fly
worm
Publications
First Neural induction by the secreted polypeptide noggin., Science 1993  
Most Recent Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates., EMBO J 2021                          
All View All Papers 137 paper(s) referencing morpholinos 14 paper(s) referencing OMIMs 26 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 6 terms 7 terms
PANTHER otx2
KEGG Pathways K18490 K18490 K18490
KOG [K] Homeobox transcription factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks otx2
Antibodies Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4
Morpholinos (on-target & off-target) otx2 MO3 , otx2 MO1 , otx2 MO2 otx2 MO3 , otx2 MO1 , otx2 MO2 otx2 MO3 , otx2 MO1 , otx2 MO2
ORFs otx2 ORF1 otx2.L ORF1 otx2.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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