Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (467) GO Terms (5) Nucleotides (273) Proteins (33) Interactants (2202) Wiki
XB-GENEPAGE- 485219

Gene Symbol: otx2

Gene Name: orthodenticle homeobox 2

Synonyms: Xotx2 , otx-2 , Xotx-2 , otxA , otx2-a , otx2-b
Add Xenopus synonyms , Nomenclature history

Gene Function: homeodomain transcription factor

Protein Function :
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer ...[+]


Interactants: Loading ...

Disease Ontology Associations: MICROPHTHALMIA

OMIM Disease Associations: ORTHODENTICLE, DROSOPHILA, HOMOLOG OF, 2; OTX2 [+]
1/5
 
Xenbase Gene ID XB-GENE-485220 XB-GENE-485224 XB-GENE-6254039
Gene Symbol otx2 otx2.L otx2.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.10021 [+] Xl.47281 Xl.3004
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 326 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine otx2 otx2.L otx2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tgas114a06      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards OTX2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Otx2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR otx2b otx2a ZFIN Ensembl
chicken
GEISHA OTX2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Neural induction by the secreted polypeptide noggin. [Science 1993]
Most recent: Roles of Xenopus chemokine ligand CXCLh (XCXCLh) in early embryogenesis. [Dev Growth Differ 2018]
View All Papers 131 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 11 paper(s) referencing Disease Ontologies
Functional Ontologies tropicalis laevis.L laevis.S
GO 4 terms 4 terms 5 terms
PANTHER otx2
KEGG Pathways K18490 K18490 K18490
KOG [K] Homeobox transcription factor
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s)   EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Antibody Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4
Morpholino otx2 MO1 , otx2 MO2 , otx2 MO3 otx2 MO1 , otx2 MO2 , otx2 MO3 otx2 MO1 , otx2 MO2 , otx2 MO3
ORF otx2 ORF1 otx2 ORF2
Affymetrix 1.0 Str.10021.1.S1_at [+] Xl.11672.1.A1_at [+] Xl.1268.1.S1_at
Affymetrix 2.0 Xl2.47281.1.S1_at Xl2.3004.1.S1_at

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.0
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556