Gene Symbol: lef1 Gene Name: lymphoid enhancer-binding factor 1 Synonyms: xlef-1, lef-1, xlef1 Add Xenopus synonyms Gene Function: HMG box transcription factor, wnt signaling Interactants: tcf3(22) , tcf7l1(15) , tcf4(14) , tcf7(11) , tcf7l2(11) , dvl2(9) , sia1(9) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002939285|PREDICTED: Xenopus (Silurana) tropicalis lymphoid enhancer-binding factor 1-like (LOC100493178), mRNA GGACGGCAATGTGCCTCTTGCAGTCACTGAGGTAGGACAAGACTTTTGGGAGAGTTTTACGTGGTGTGAAGAAAGGAGATTAACTTGTCCCCCCCTCCCCAGGATTTTCTCAGAGGTGATTTTCTCAAAGTGACGCTAAACAGAAGAAGGTAGGATCGCTGGCAAAAGGTACATTCCACGGGGGGTTTGTGGACAGGTCCCTTTGCAGAGGATATGCAGCGCTTTGCTTGTCCTCCCTCTGTACCCGGTACAGACCGCAGTTTTACCTGAGGGTCCAGAGGAGGAGTTCAGTCCGCTCCTTGCCAAAAGCTCACGGCGCTCTCCAAACTTTGCTCTTACTTGCATTGAGCTGACTGGCAGTGCTAGCAGGACAAAGCCAGGCTGGCTGGGGTGTGTGGGCACCGCACAGAGAGTGGCTAGTTTACCTCGCTTATTTAAATGAAGACATCCTTTCTGGGTTAGTCATCTCTGAGTCACTGACTGCATAAAGCAAAAAACGTAATTTGCAGTTAGTCAGAACCATAACAAACACTGCAGTTTCTCACTGCTCCTCGTGTGACTGCACACACTCGCCTGAATGGGAGCAGAATGAGATAAAAGCCCATCAGCTGTGGGTGGTTTTGGATACTGGTGACTACAGTAGCCCCCCTGGACCAGGGGAGACAGGATTGGAGCCCTTGGAGCAGAGCAGAGACACACTGGGACTTGCAGCCTTGGGAGACAGGGGTGAACTTTTTACAAGCAAAAGTGTCTTCTTATCAAGATTTGTGACTTTATTTTGCTGATTTGGGGGCAAAAGTGTCCAGCCAGTGCCATCAGTTTTGGCATTTTGACCTTGGATCATTGGGTGTGGAAATTTTGGGAAGGGAACCTTTGAATTGGGTTTTGGTTTTTTTTTGCTGGTGTTTGATTTCTGACCTGTAACACAGAAGTCCTGATCTGGAGCCATGCCTCAGCTCTCTGGAGCAGGGGGGGGCAATGGGGGTGGGGGAGATCCTGAGCTGTGTGCCACAGATGAGATGATCCCCTTTAAAGATGAAGGGGATCCCCAAAAGGAGAAGATCTACGCTGAGATCAGCAACCCGGAGGAGGAGGGAGACCTCGCAGATATCAAGTCATCTCTGGTCAATGAGACTGAGATTATCCCCAGTAGCAACAGTCACGAGATTTCCAGAAGAAGACAAGACTCTTATCATGAAAAATCTAGAGAACATCCAGAAGATGCAGGAAAACATCCGGATGGCGGCTTATACAGCAAAGGCCCTTCTTATACTGGATACCCAAGCTATATCATGATGCCAAATATGAATAATGAGCCTTACATGTCAAATGGATCTTTGTCTCCTCCCATTCCAAGAACATCAAACAAAGTCCCAGTGGTGCAGCCATCACATGCCATCCATCCTCTAACACCACTCATTACTTATAGTGACGAGCACTTTGCACCGGGAGCACACCCTTCACATATCCCATCAGATGTCAACTCAAAGCAAGGCATGCACAGGCATCCTCAAGCCCCAGACCTCCCTACATTTTACCCTCTGTCGCCTGGAAGTGTGGGCCAGATGACACCACCATTGGGCTGGTATCCGCACCATATGGTTTCTGGTCCTCCGGGCCCTCACGCAACTGGAATTCCTCACCCAGCTATTGTCAATCCTCAGGTTAAACAAGAACATCCACACAATGACAATGACCTAATGCACATGAAACCTCACCACGAACAGAGAAAAGAGCAGGAACCCAAAAGACCTCACATAAAGAAGCCTCTGAATGCTTTCATGTTGTATATGAAAGAAATGAGAGCGAATGTAGTAGCAGAATGTACTCTCAAAGAAAGTGCTGCCATCAACCAGATTCTGGGTAGAAGGTGGCATGCATTGTCTCGGGAAGAACAGGCCAAATATTATGAGTTAGCTCGCAAAGAAAGGCAACTACACATGCAGCTTTACCCAGGATGGTCTGCAAGGGACAACTATGGTAAAAAAAAGAAGAGGAAGCGGGAGAAGCTGCAGGAATCCACATCAGGTGCAGGCCCACCAAGAATGACAGCTGCCTACATCTGA	Refseq >NM_001088655|Xenopus laevis lymphoid enhancer-binding factor 1 (lef1), mRNA ATGCCTCAGCTCTCTGGAGCAGGGGGCGGCAATGGGGGTGGGGGGGATCCTGAGCTGTGTGCCACCGATGAGATGATCCCCTTTAAAGATGAAGGGGATCCCCAAAAGGAGAAGATCTATGCCGAGATCAGCAACCCAGAGGAGGAAGGAGACCTCGCAGATATCAAGTCGTCTCTGGTCAATGAGACTGAGATTATCCCCAGCAGCAACAGTCACGAGATTTCCAGGAGAAGACTAGACTCTTACCATGAAAAATCAAGAGAACATCCAGAGGATGCAGGAAAACATCCGGATGGAGGCTTATACAGCAAAGGCCCTTCTTATACTGGATACCCAAGCTATATCATGATGCCAAATATGAATAATGAGCCTTACATGTCAAATGGATCTTTGTCTCCACCCATTCCAAGAACATCAAACAAAGTCCCAGTGGTGCAGCCATCGCACGCCGTCCATCCTCTAACCCCACTCATCACTTACAGTGACGAGCACTTTGCACCAGGAGTACACCCATCACACATCCCATCAGATATCAACACAAAGCAAGGCATGCACAGGCATCCTCAAGCACCAGACCTACCTACATTTTACCCAATGTCCCCAGGAAGTGTGGGCCAGATGACACCACCATTGGGCTGGTATCCACACCATATGGTTTCTGGTCCTCCGGGCCCTCACGCAACTGGAATTCCTCACCCAGCTATTGTCAATCCTCAGGTTAAACAAGAACATTCACACAATGACCATGACCTAATGCACATGAAACCACACCACGAACAGAGAAAAGAGCAGGAACCCAAAAGACCTCACATAAAGAAACCTTTGAATGCTTTCATGTTGTATATGAAAGAAATGAGAGCGAATGTAGTAGCAGAATGTACTCTCAAAGAAAGTGCTGCCATCAACCAGATTCTGGGAAGGAGGTGGCATGCATTGTCCCGGGAGGACCAGGCCAAATATTATGAGTTAGCTCGCAAAGAAAGGCAACTACACATGCAGCTCTATCCAGGATGGTCTGCAAGGGACAACTACGGTAAAAAAAAGAAGAGGAAGCGGGAGAAGTTGCAGGAATCCACATCAGGTGCAGGCCCCCCAAGAATGACAGCTGCCTACATCTGA
Protein		NCBI Protein >XP_002939331|PREDICTED: lymphoid enhancer-binding factor 1-like [Xenopus (Silurana) tropicalis] MPQLSGAGGGNGGGGDPELCATDEMIPFKDEGDPQKEKIYAEISNPEEEGDLADIKSSLVNETEIIPSSNSHEISRRRQDSYHEKSREHPEDAGKHPDGGLYSKGPSYTGYPSYIMMPNMNNEPYMSNGSLSPPIPRTSNKVPVVQPSHAIHPLTPLITYSDEHFAPGAHPSHIPSDVNSKQGMHRHPQAPDLPTFYPLSPGSVGQMTPPLGWYPHHMVSGPPGPHATGIPHPAIVNPQVKQEHPHNDNDLMHMKPHHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGAGPPRMTAAYI	Refseq >NP_001082124|lymphoid enhancer-binding factor 1 [Xenopus laevis] MPQLSGAGGGNGGGGDPELCATDEMIPFKDEGDPQKEKIYAEISNPEEEGDLADIKSSLVNETEIIPSSNSHEISRRRLDSYHEKSREHPEDAGKHPDGGLYSKGPSYTGYPSYIMMPNMNNEPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFAPGVHPSHIPSDINTKQGMHRHPQAPDLPTFYPMSPGSVGQMTPPLGWYPHHMVSGPPGPHATGIPHPAIVNPQVKQEHSHNDHDLMHMKPHHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREDQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGAGPPRMTAAYI

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.10421	Xl.85523
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		8 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	LEF1
mouse		MGI	Lef1	All(6) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN	lef1	12 Lines(s)

Publications
First:		XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. [Cell 1996]
Most recent:		The XenopusTGFBI is required for embryogenesis throughregulation of canonical Wnt signalling. [Dev Biol 2013]
		View All Papers 10 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding
Biological:		regulation of transcription, DNA-dependent
Cellular Component:
EC:
KOG:		[K] Transcription factor TCF-4

Reagents		tropicalis	laevis
Clones			EXRC - 4 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.10421.2.A1_at [+] Str.10421.1.S1_at	Xl.410.1.S1_at
Affymetrix 2.0			Xl2.410.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images