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Summary Expression Gene Literature (2) GO Terms (10) Nucleotides (108) Proteins (38) Interactants (155) Wiki
XB-GENEPAGE-485590
Gene Symbol:
spred2

Gene Name:
sprouty related, EVH1 domain containing 2

Synonyms:
Xspred2 , Xtspred2 ( Add synonyms , Nomenclature history )

Gene Function:
regulation of signal transduction

Protein Function :
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-485591 XB-GENE-17334387 XB-GENE-6486012
Gene Symbol spred2 spred2.L spred2.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 496441
101027290
108717624
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine spred2 spred2.L spred2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SPRED2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Spred2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Spred2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR spred2b spred2a ZFIN Ensembl
chicken
GEISHA SPRED2 Ensembl
fruit fly
worm
Publications
First FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation., Dev Cell 2005        
Most Recent Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes., J Genet Genomics 2011                                                                                                                                                            
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 3 terms 3 terms
PANTHER spred2
KEGG Pathways K04703 K04703
KOG [T] Signal transduction protein Enabled, contains WH1 domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks spred2
Morpholinos (on-target & off-target) spred2 MO2 , spred2 MO1 spred2 MO2 , spred2 MO1 spred2 MO2 , spred2 MO1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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