Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (122) GO Terms (7) Nucleotides (194) Proteins (25) Interactants (515) Wiki
XB-GENEPAGE- 485690

Gene Symbol: smad4.1

Gene Name: SMAD family member 4, gene 1

Synonyms: XSmad4alpha , Xsmad4 , jip , dpc4 , madh4 , XSmad4a , smad4a , smad4alpha
Add Xenopus synonyms , Nomenclature history


Gene Function: signal transduction, tgf-beta pathway

Protein Function:


Interactants: YYY

OMIM Disease Associations: JUVENILE POLYPOSIS SYNDROME; JPS [+]
 
Xenbase Gene ID XB-GENE-485691 XB-GENE-865543 XB-GENE-17334633
Gene Symbol smad4.1 smad4.1.L smad4.1.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.26661 [+] Xl.885 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 6 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine smad4.1 smad4.1.L smad4.1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tneu052c18      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SMAD4 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Smad4 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN smad4a ZFIN Ensembl
chicken
GEISHA SMAD4 Ensembl
fruit fly
worm
WORMBASE
Publications
First: A human Mad protein acting as a BMP-regulated transcriptional activator. [Nature 1996]
Most recent: A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy. [Oncotarget 2014]
View All Papers 19 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 7 terms 0 term
EC
PANTHER smad4.1
KEGG Pathways K04501
KOG [TK] TGFbeta receptor signaling protein SMAD and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino smad4.1 MO1 , smad4.1 MO2 smad4.1 MO1 , smad4.1 MO2 smad4.1 MO1 , smad4.1 MO2
Affymetrix 1.0 Str.51998.1.S1_at Xl.885.1.S1_at [+]
Affymetrix 2.0 Xl2.885.2.S1_a_at [+]

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556