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Summary Expression Gene Literature (140) GO Terms (61) Nucleotides (213) Proteins (38) Interactants (832) Wiki
XB-GENEPAGE-485690
Gene Symbol:
smad4

Gene Name:
SMAD family member 4, gene 1

Synonyms:
XSmad4alpha , Xsmad4 , jip , dpc4 , madh4 , XSmad4a , smad4a , smad4alpha , smad4.1 ( Add synonyms , Nomenclature history )

Gene Function:
signal transduction, tgf-beta pathway

Protein Function :


InterPro :
SMAD FHA dom sf , Kinesin-like KIF1-typ , Kinesin-like , P-loop NTPase [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
juvenile polyposis syndrome [+]

OMIM:
PANCREATIC CANCER [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-485691 XB-GENE-865543 XB-GENE-17334633
Gene Symbol smad4 smad4.L smad4.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038088
780764
108707339
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein RefSeq  More.. NCBI Protein TrEMBL
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine smad4 smad4.L smad4.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu052c18      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards SMAD4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Smad4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Smad4 Ensembl
zebrafish
ZFIN, AGR smad4a ZFIN Ensembl
chicken
GEISHA SMAD4 Ensembl
fruit fly
Publications
First A human Mad protein acting as a BMP-regulated transcriptional activator., Nature 1996  
Most Recent Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage., Biol Open 2021                  
All View All Papers 20 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 60 terms 9 terms 8 terms
PANTHER smad4
KEGG Pathways K04501 K04501
KOG [TK] TGFbeta receptor signaling protein SMAD and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks smad4
Mutants Xtr.smad4.1mZimml
Antibodies Smad4 Ab1 Smad4 Ab1 Smad4 Ab1
Morpholinos smad4.1 MO1 , smad4.1 MO2 smad4.1 MO1 , smad4.1 MO2 smad4.1 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info