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Summary Expression Gene Literature (364) GO Terms (13) Nucleotides (83) Proteins (37) Interactants (874) Wiki
XB-GENEPAGE-485984
Gene Symbol:
nkx2-1

Gene Name:
NK2 homeobox 1

Synonyms:
ttf1 , nkx2.1 , titf1 , Xnkx-2.1 , xnkx2-1 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :


InterPro :
ADH C , GroES-like sf , PKS ER , ADH N [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
choreatic disease [+]

OMIM:
THYROID CANCER, NONMEDULLARY, 1; NMTC1 [+]

External Links:
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Xenbase Gene ID XB-GENE-485985 XB-GENE-865567 XB-GENE-17336526
Gene Symbol nkx2-1 nkx2-1.L nkx2-1.S
Chromosome Chr8 chr8L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100135015
373626
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein TrEMBL  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nkx2-1 nkx2-1.L nkx2-1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NKX2-1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nkx2-1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nkx2-1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR nkx2.4b nkx2.1 ZFIN Ensembl
chicken
GEISHA NKX2-1 Ensembl
fruit fly
worm
Publications
First Gli1 is a target of Sonic hedgehog that induces ventral neural tube development., Development 1997                    
Most Recent Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism., Horm Res Paediatr 2020  
All View All Papers 15 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 12 terms 5 terms 0 term
PANTHER nkx2-1
KEGG Pathways K09342 K09342
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nkx2-1
Antibodies Nkx2-1 Ab1 , Nkx2-1 Ab2
Morpholinos nkx2-1 MO1 , nkx2-1 MO2 nkx2-1 MO1 , nkx2-1 MO2 nkx2-1 MO1 , nkx2-1 MO2
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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