smad7 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (35)

Nucleotides (194)

Interactants (167)

XB-GENEPAGE-486003

Gene Symbol: smad7 Gene Name: SMAD family member 7 Synonyms: xsmad7 Add Xenopus synonyms Gene Function: signal transduction, TGF-beta pathway Interactants: tgfb1(18) , smad2(12) , smad1(10) , smad6(10) , smad3(8) , smad6.2(8) , bmp4(6) View All

XB-GENE-486004

XB-GENE-865569

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002936507\|PREDICTED: Xenopus (Silurana) tropicalis mothers against decapentaplegic homolog 7-like (LOC100486892), mRNA ACATTTCCATAACACAGACGGGGGCGGATCAGCCCTTTGAGAAGGAGGAAAAGACAAGTCCCACTTTATTTTTTTCCCCTCTCTCCTACTGAGCGGCCGGATAAAGGATTTTTCTTGTGGATTAAACAAGCGAGAGGCGCAACCCAGGGCTTCTACTTCTTTACTGGAACCGCATCGCGTACGGATTATCTATAAGGTTCTGCCGCCCTAGTGCCCCTACTCTCTGCCCATTTGCCCCCCATACACAAGGGATATTATCGGCAGACCCGCTCGTTTGTGGATGTACGAGTTGTGGGGGGAGCCCGCTTTCCTACCGGGAGGATTGTGTATAAATGCCCTTTAGATCCCAGGCCAAGCCGGGCAGCGCTCTGTGCTCCATTCAATGCCCCGCTGCTCCCGGCTCGGCTGCCCAGCATTAGCCCGCTGTATGTGTAGCCGGGGCGGCTGCTTGCCGTTTGCAGTATTCCTGTCGCTGCGACTCGGATCCCCCCGCCGCACTTTGCAGGATCTCTTCCCCTAAAAGACTGGCGCATGTTCCAGATCGCTTTGGCTTGTCGGACCCCCAGCTCCCCCCTACCCTCCCGGGCTGCTGCTGCTGGTCTCTGCCCGGCCTCGGATCCAGGATTCTTCATGATTTGCGGGCGTCATGCACGTTGTTTAGCCGGGAAGCCTTGCTCTCGTCCCGCATGTTCAGGACCAAACGATCGGTGCTCGTCCGGCGACTCTGGAGGAGCCGAGCTCCCGGGGAGAGCGGGGAAGGGGAAGGCGGGGAGAGGGTTCATGGAGCCGGGGGTTGCTGCCTGGGCAAATCGGCGAATAAGGTGCCCGGGAAGGCGCTGGGGGGCTCGGAGGCTGCAGAACTGAAAGCCCTCGCCCACTCCGTGCTGAAGAAGCTGAAGGAGAAGCAGCTGGAGGGGCTGCTGCAGGCGGTGGAGTGTAAAGGGGGAGCCCGCAGCCCCTGCCTGTTGCTGCCGGCGGCCAAGCTGGACTCCAGGCTGGGGCAGCAGCCCTTCTCCCTGCCGCTGCTGCTCTGCAAGGTCTTCAGGTGGCCGGACCTCAGGCACTCGTCCGAGGTCAAACGACTTAGTTGCTGCGATTCCTATGGCAAGAACAACCCGGAGCTGGTCTGCTGCAACCCGCACCATCTCAGCAGGCTGTGCGAACTAGAATCTCCCCCACCTCCCTACACCAGATACCCCATGGACTTTCTCAAACCGACTGCGGATTCTCCAGACTCTGTCCCTTCCTCCACAGAAACAGGGGGAACAAATTTTTTGGCCCCTGAGGGGCTTTCAGNCTTCTATGATCTACCTCAAGGGAACGGCTTCTGCCTTGGGCAGTTGAACTCGGACAATAAAAGTCAGTTGGTGCAGAAGGTCCGCAGCAAAATCGGATACGGGATCCAGCTGACCAAGGAGGTCGACGGCGTGTGGGTCTATAACCGCAGCAGTTACCCCATCTTCATCAAGTCTGCCACACTGGACAACCCGGACTCTAGGACGTTATTGGTCCACAAAGTGTTCCCTGGATTTTCCATCAAAGCGTTTGACTACGAGAAGGCTTACAGTTTGCAGAGACCCAATGACCACGAGTTCATGCAGCAACCATGGACCGGATTTACTGTACAGATAAGCTTTGTCAAAGGCTGGGGCCAATGTTACACGAGACAGTTCATCAGCAGTTGCCCGTGCTGGCTGGAGGTGATATTCAATAACCGGTGA	Refseq >NM_001087548\|Xenopus laevis SMAD family member 7 (smad7), mRNA GTGCTGTGGATTAAAGGCGCGAGGCTGGCAATGGAATAGGGATGATCTGACACATTATATATATATATTATACACTGGCAGAGCCTCATTCCTCTCCCACTTGGATGTAACAGTTGTGGGGGGGAATCTGCTTTCCGCACGTGGAGGATTTAATTTCAATGCCACAGAGATCGCTGGTCCGGCGCAGATTGCGCTCCATTCAATGCGCCGCCGGTCAGTGTTGTTTGTCGGTGTAGGAGCGCGGGGAGGCGGAGGCGGCTGGTTGTTGTTGTTGCAGCCGCCGGTGCTGCCGCTCGGATCCCCCCCGTACACTTTGCATCAGGATCTCTTTGCCTAAAAGACTGGCGCATGTTCCAGGTCACTTTGGCTTGTCGGATCCCCAGCTCCCCCCGACCCTCCCGACCCCTCCAAGCTGCTGTTGCTGCTGGTCTCTGTCCGGCCTCGGATCCAGGATTCTTCATGATTTGCGGGCGACATGCACGTTTTTTAGCCGGGAAGCCTTGCTCTCGTCCCGCATGTTCAGGACCAAACGATCGGTGCTCGTCCGGCGACTCTGGAGGAGTCGAGCTCCCGGGGAGAACGGGGAAGGGGAAGGCGGGGAGAGGGCGCATGGAGCCGGCGGCTGCTGTCTGGGCAAATCGGCGAATAAGGTGCCCGGGAAGGCGCTGGTGGGCTCGGAGGCTGCAGAACTGAAAGCGCTCGCCCATTGTGTCCTGAAGAAGCTGAAGGAGAAGCAACTGGAGGGGCTGCTGCAGGCGGTGGAGTGTAAAGGGGGAGCCCGCAGCCCCTGTCTCCTGTTACCCGCGGCCAAGCTGGACTCCAGGCTCGGGCAACAAGCCTTCTCTCTGCCGCTGCTCCTCTGCAAGGTCTTCAGGTGGCCGGATCTCAGGCACTCGTCCGACGTCAAGCGACTTAGTTGCTGCGACTCCTATGGCAAGAACAACCCGGAGCTGCTCTGTTGCAACCCCCACCATCTCAGCAGACTGTGCGAGCTAGAATCTCCCCCACCTCCCTACACCAGATACCCCATGGACTTTCTCAAACCCACTGCGGATTCCCCAGACTCTGTCCCTTCCTCCACAGAAACAGGGGGAACAAATTTTTTGGCCCCTGAGGGGCTTTCAGATTCCCAACTTCTTCACGAGACTGGGGACCCGTCCCACTGGTGCATGGTGGCGTATTGGGAAGAGAAAACGAGGGTGGGTCGCTTATATTCTGTCCAAGAGCCCTCCCTGGATATCTTCTATGATCTACCTCAAGGGAACGGCTTCTGCCTTGGGCAGTTGAACTCGGACAATAAAAGTCAGCTGGTGCAGAAGGTCCGCAGCAAAATCGGCTACGGCATCCAGCTGACCAAGGAAGTGGACGGCGTCTGGGTCTACAACCGCAGCAGTTACCCCATCTTCATCAAGTCTGCCACACTGGACAACCCAGACTCTAGGACGTTATTGGTCCATAAAGTATTCCCTGGATTTTCCATCAAAGCGTTTGACTATGAGAAGGCTTACAGTCTGCAGAGACCTAATGACCACGAGTTCATGCAACAACCATGGACCGGATTTACTGTACAGATAAGCTTCGTCAAAGGCTGGGGCCAATGTTACACGAGACAGTTTATCAGCAGTTGCCCGTGTTGGCTGGAGGTGATATTTAATAACCGGTGACTCGGACACGAGCGGACATCTGGACTCTCAACTACTTTGCTGCTAATATTTCCTCCTGAGTGCTTGCTTCTTCCCGCGGACTTGTTTTTACGTTTTTTTGTTCGTTTTGAGAAATAGCTTATGTCAAGAATGACCTTTTTCTCATTCTGTTCTTGCCTGTGTGAATGACTTCAGGCCGAGCTTTGCCCCGGGTAGGGGACGGGTGCTTGGGCAACGCGTGGAGTGTGCTTGTAATGGGTTTTTTTGGGGGAGGGTATCGACCGCTTTCTTGTGCAATGAATAGAAGATATTTTTGTCTAGGGTGGGGGGTTAGGACTGGGCTGAATTCAGTATTTTTCTTTTGCATATGGGTGACCACTACTACGCCTCCCATCTCCTAAGTAAGGGCACGGCTGTATCAAGTATTCTAGTGGGCGACTTTAGAGCGACATCTAAGGTGTTTTTATTGGTTTATCCGTTGCAGGGATAACGGGAAAGGATGCTGATGCTGTTGCTAAGCAACGGCAAGGCCAATAATAATAATAAAGGCACCTTAGGTTGCTCTGCTACTATTTCTGCTGTCCTATAGCGAAACGAGCACTGCAGACTCTTCAGACCAATGTCTTTTATTCACGACTGGTAATTATACATTTCACATGGATCACTCTCCAGGTCCGCTCCCGACCCAAGGTGTAAACATTATTGCGGAGTCTGATTTGCAGTGATCTGTTGTCCTATATCCCCGATAAAGACCAAACCCAAAAAAAAAAACTGCCATGCTGTTACCTGCCCCCCCCCCCCCCCAAAAAAAGAAAATCAAATAATCCAATTTCTTGGACATGCGGTTTGTTGTTTTAAACAGACCATTACAGGATAACTGCCCAACTTGACCTTTCTCCATGTTATTTCAGTCCCCTTGGTGGAAAGGGTTAACACGTTATTTATTTTTTATTGTTTTGCATATGTATATTCTGTGAGAATCACAATTTCAGGCATGGTCCTTAACCCCTAGACTCTCAAAGGTGCATTCGGTAGTAAAGGAGTTAATCCCCTGACTTCATGATCTCAATTGCAATACAGGGAATTGTGGATCAGGCGGAGGGTAATCCCTTATATGTTAAATATGGAACATTGAGGCAATGCCTCTTTTTATTATAGGTTCCGGAAATTATTCTGGGAGACCTGATTGGTTGCTGGTTTTACCTCCACCATAATGCAAATATGACCATGATGTTGGTGAATTACAACTCCCGGCATTATGGGACTTGTAGTCTAACAATATCTCGGAAGCCAATGTTCAGTAAGGGACTATCCTCCAAGACCCACAACCCCTACAAGGGGAAATTAACTTTGCCTTTATTTCTTTCAATGACAGTGTATACACAACTCATGAATATGTCTGAGATGAAACATACAGTATTTGCTCTTTACTTTCTTCTCCTTTATAAGGTACACGTTATGCACAGGGAAGGGTTCAATTTAATTTTTTTTTTTCCCTCGTTCATTTCCTCTTAATATCATACATGGAGTGTGGTAACTTTAGCATTTTCCTAGCTCAGTGAGCATGTTTAACATAAGCTATTTTTCTAAATCCCGAAGTTTAAACGATCAAGAAAAAAAAGGGCACTCTTTGGAACTTAACGCAACGTAGTGCTTTGGAAAAAAAAAACCCGAAAAGGATTAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002936553\|PREDICTED: mothers against decapentaplegic homolog 7-like [Xenopus (Silurana) tropicalis] MFRTKRSVLVRRLWRSRAPGESGEGEGGERVHGAGGCCLGKSANKVPGKALGGSEAAELKALAHSVLKKLKEKQLEGLLQAVECKGGARSPCLLLPAAKLDSRLGQQPFSLPLLLCKVFRWPDLRHSSEVKRLSCCDSYGKNNPELVCCNPHHLSRLCELESPPPPYTRYPMDFLKPTADSPDSVPSSTETGGTNFLAPEGLSXFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGYGIQLTKEVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNNR	Refseq >NP_001081017\|SMAD family member 7 [Xenopus laevis] MFRTKRSVLVRRLWRSRAPGENGEGEGGERAHGAGGCCLGKSANKVPGKALVGSEAAELKALAHCVLKKLKEKQLEGLLQAVECKGGARSPCLLLPAAKLDSRLGQQAFSLPLLLCKVFRWPDLRHSSDVKRLSCCDSYGKNNPELLCCNPHHLSRLCELESPPPPYTRYPMDFLKPTADSPDSVPSSTETGGTNFLAPEGLSDSQLLHETGDPSHWCMVAYWEEKTRVGRLYSVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGYGIQLTKEVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNNR

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.66607 [+] Str.37464	Xl.1228 [+] Xl.24742
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		27 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tneu095k24

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SMAD7	OMIM:114500 OMIM:612229
mouse		MGI	Smad7	All(7) Targeted, knock Out(3) Gene Trapped(1) Targeted, other(1)
zebrafish		ZFIN	smad7	4 Lines(s)

Publications
First:		Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. [Nature 1997]
Most recent:		Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. [Proc Natl Acad Sci U S A 2012]
		View All Papers 3 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		intracellular
EC:
KOG:		[TK] TGFbeta receptor signaling protein SMAD and related proteins

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.37464.1.A1_at [+] Str.40330.1.S1_at Str.10751.1.S1_at	Xl.1228.1.S2_at [+] Xl.1228.1.S1_a_at Xl.1228.1.S2_a_at Xl.24742.1.S1_x_at
Affymetrix 2.0			Xl2.1228.1.S2_at [+] Xl2.1228.1.S1_a_at Xl2.52217.2.A1_at Xl2.52217.1.S1_at Xl2.24742.2.S1_a_at

Symbol legend[+]