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Summary Expression Gene Literature (26) GO Terms (4) Nucleotides (359) Proteins (66) Interactants (240) Wiki
XB-GENEPAGE- 486121

Gene Symbol: btrc

Gene Name: beta-transducin repeat containing E3 ubiquitin protein ligase

Synonyms: Beta-TrCP , betaTrCP , fwd1 , fbw1a , fbxw1 , btrcp , fbxw1a , btrcp1
Add Xenopus synonyms , Nomenclature history


Gene Function: F-box protein/ubiquitin protein ligase complex component

Protein Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Proba...[+]


Interactants: Loading ...

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-486122 XB-GENE-17339405 XB-GENE-865578
Gene Symbol btrc btrc.L btrc.S
Chromosome Chr07 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq NCBI Nucleotide Refseq
Protein Refseq NCBI Protein TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.17301 [+] Xl.968 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 2 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine btrc btrc.L btrc.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards BTRC OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Btrc MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN
chicken
GEISHA BTRC Ensembl
fruit fly
worm
WORMBASE
Publications
First: beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos. [Mech Dev 1998]
Most recent: Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition. [Dev Cell 2017]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 1 terms 4 terms
EC now EC:2.7.11.7
PANTHER btrc
KEGG Pathways K03362
KOG [S] Beta-TrCP (transducin repeats containing)/Slimb proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones     EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Btrc Ab1 Btrc Ab1
Morpholino btrc MO1 btrc MO1 btrc MO1
ORF btrc ORF1
Affymetrix 1.0 Str.21617.1.S1_at [+] Xl.968.1.S1_s_at [+]
Affymetrix 2.0 Xl2.968.1.S2_at [+]

Symbol legend[+]

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