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Summary Expression Gene Literature (8) GO Terms (33) Nucleotides (78) Proteins (31) Interactants (275) Wiki
XB-GENEPAGE-486137
Gene Symbol:
hes2

Gene Name:
hes family bHLH transcription factor 2

Synonyms:
XHes2 ( Add synonyms , Nomenclature history )

Gene Function:
helix-loop-helix transcription factor/transcriptional repressor

Protein Function :
Transcriptional repressor. Essential in the retina to govern glial versus neuronal differentiation. Promotes gliogenesis through the inhibition of neuronal differentiation by at least two distinct mech...[+]


InterPro :
Leu-rich rpt , Kinase-like dom sf , Leu-rich rpt typical-subtyp , COR [+]

Interactants:
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Diseases: 


External Links:
1/2
 
Xenbase Gene ID XB-GENE-486138 XB-GENE-865581 XB-GENE-17330530
Gene Symbol hes2 hes2.L hes2.S
Chromosome Chr7 chr7L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100038090
495039
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hes2 hes2.L hes2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards HES2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Hes2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Hes2 Ensembl
zebrafish
chicken
fruit fly
worm
Publications
First Characterization and function of the bHLH-O protein XHes2: insight into the mechanisms controlling retinal cell fate decision., Development 2006                  
Most Recent Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis., Genes (Basel) 2020                    
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 26 terms 10 terms 0 term
PANTHER hes2
KEGG Pathways K04280 [+] K09087
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hes2
Morpholinos (on-target & off-target) hes2 MO2 hes2 MO1 , hes2 MO2
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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