Gene Symbol: pias1 Gene Name: protein inhibitor of activated STAT, 1 Synonyms: xPIAS1, gbp, zmiz3, ddxbp1, pias Add Xenopus synonyms Gene Function: zinc finger transcription factor Interactants: frat1(19) , gsk3b(12) , gys1(8) , dvl2(5) , pias4(5) , ube2i(3) , apcs(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932944|PREDICTED: Xenopus (Silurana) tropicalis e3 SUMO-protein ligase PIAS1-like (LOC100488714), mRNA ATGGCGGACAGTGCGGAACTGAAGCAAATGGTTATGAGTCTTAGAGTTTCCGAGCTGCAAGTGCTTTTGGGATACGCTGGGCGCAACAAACACGGTCGTAAACACGAACTGTTGACCAAAGCTCTTCACTTGCTTAAGACTGGGTGCAGCCCCGCTGTGCAAATGAAAATCAAGGAATTATATCGGCGGAGGTTCCCCTTGAAAATTTTGACTCCTGCTGACTTCTCTTTGCCCAGTGTGCACTCAAGCTCTATGCCAGTCAACCTGTCACCATCCTCCATTCCTCAGCTCTCTTATGATGGTCATCCAGCTTCTTCTCCATTAATGCCAGTCTCCCTCCTCCCCAAACATGAACTGGATCTCCCACACCTCGCATCAAATCTTCACCCTGTCCATCCGGATGTCAAACTGCAAAAACTTCCCTTCTATGACCTGCTGGATGAACTTATCAAACCCACAAGTTTAGCATCTGATAATAGTCAGCGCTTTCAAGAAACCTGCTTTGCGTTTGCATTAACACCGCAACAAGTACAACAGATAAGCAGCTCAATGGATATCTCTGGGACAAAATGTGACTTCACAGTACAAGTGCAGCTCAGGTTCTGTCTCTCTGAGACAAGCTGCCCCCAAGAAGATCATTTTCCACCAAATCTGTGTGTAAAGGTGAATGGAAAACCATGTAACCTTCCAGGGTATCTTCCACCAACTAAAAATGGGGTTGAACCAAAGCGACCTAGTCGACCAATCAATATTACCTCACTTGTACGGCTTTCCACAACAGTCCCAAACACAATTGTGGTGTCGTGGACTGCAGAAATTGGAAGGAATTTTTCTTTGGCTGTTTATCTGGTGAAGCAGCTTTCATCGGCCATCTTGCTTCAGAGACTGCGAGCAAAAGGAATCCGCAACCCTGACCATTCCAGGGCTCTGATTAAGGAGAAGCTCACAGCTGATCCAGACAGTGAAATCGCCACAACCAGTTTACGTGTCTCCCTTCTGTGTCCGCTTGGTAAGATGCGCCTGACCATTCCCTGCCGGTCCCTTACATGCTCACACCTTCAGTGCTTTGATGCCACACTCTACATCCAGATGAATGAGAAGAAGCCCACCTGGGTTTGTCCTGTTTGTGACAAGAAGGCCCCATATGAGCATTTAATCATAGATGGTCTTTTTATGGAGATATTGAAATGCTGCACAGACTGTGATGAAATACAGTTTAAGGAAGATGGCTCCTGGTCACCCATGCGATCAAAGAAGGAAGTACAGGAGGTCACAACCTCTTATAATGGAGTGGACAGTGGGTGCATCAGCAGCTCAGTTGAGCATCAGGTTTCCTCCAACCAACAATCCTCCAAAAACAAAAAGGTGGAAGTGATTGACCTGACAATAGACAGCTCTTCAGATGAGGAGGAAGAGGAACCCTGTCCCAAGAGGAGTTGCCCATCCATTACTCCTGCTTCCCCTCTCAGCAATAAGGGTATGTTAAATCTCCAGCATCAGGCCTCTCCAATTTCTCGAACTCCCAGCCTGCCACCTGTTGACTCAACATACATCAATGCACCTATACTTCAGGACTATCGGCATCCCTTCCACATGACACACATGCCATATGACTTACAAGGCCTGGATTTCTTTCCTTTCCTGTCTGGAGAAAACCAGCATTACAACACGTCACTGTTGGCGGCAGCCGCTGCTGCAGCATCAGAAGAGCCAGATTTGCTTCATTCTTCCCGCTTCTTCCCCTACACTTCTTCCCAACTTTTCTTGGACCAGTTAAATGCAAGTGCAAGCTCTTCTTTGCCAGCAACTAACGGGAGCAACAGTGGCAGTAACAGCAGCTTGGTATCGTCGAACAGCCTTCGTGAATCCCACAGTGCCCCCAGCCGCGGGCCAGCAGACAGCTCCTCACTTTATGGCATCATGCCAGATGTTATCTCCTTGGACTGATTGACAGATACAGGACCCCTACCACCTGATTTCTTTATTTTATTGTTTTTGTTTTTTAAGGGAAATGCTAAAAATACAAAAAAAAAAGCTAAAGACATGTACAGAGAACAGAACTATATTTTCAGTTTTAATTTTGTATATAAACCGAAGACTTTACTCATCTGATAAAACTGAAACCTGGCCCCGCTTCTTACTCACTCTCCCCCCACTTCATTTTAAGTTTTCAACCTAATCACAGAGATTGACTCTTGGTCTGGAGACTTCTCTGACCTTTTTTTTTTTTTCTTTTTTCTTTTCTTTTTTTAAATAAAGCTTCCCAGCATCACTCATCCCACTGCACTCTACAGCAGCCACCATTTTGGTATGGCCTGAGATGCCTCTACCATTTTGATGCTTCTAGAAATCCAAATTCAAAGACTGTTGAATGAACCCCGGCTCATTAAATTCTGCACTTCCTTATGGCAATCCAGGTTAGCTCGGAGGCAGCAACTCAGACATTGGCTTCCCCTTTTAAACCAAGAACGACTTTGGAGTTTCAAAATGCTTTGCTGCCAAATGGACATTTCAGAAAAAAAGCACTTCAGTCTGCAATCAGCACTAAATAAATGTCATAGTGTATCTGTAATTTGCTCTAGCTGGATTTTATTCATTGTTACAGATACATCATGATTTTAGGTCACTTGAGTAAATGACAATAAGATGATTGCCCCCTTCCTTTTCTGTCTTGCTGTCAAGATTTTAGTTCCAGCTACATCTCCTCAATCAGTCTTGCAGCATTCTGCAAAACACATTGGAGTCTGGTGCCAATCAAATCTCACTTAGGCATTGTTACTTTCTCTTTGGAAGTTGACTACAAAAAACTTCCATCATGTCTGTCTAGCTATCCTTTGGGTTCTGTCATAAGTGTGACCTGAGCTCACTCCAGTGTGTAATGCATCTGTGAATCCCTACTGCAACGAAAATAATTGGTGTATAGGTATAATTATCTGACGCTTTAAACAAGATTCATATGTGGTCTAATGGTGGTAAAGGAAGGGATGTCATTGGTTTGTCTGGCCCAGGATCTGTGTAGCATCTTTGTGTTGGTTGGGGACAAGTTAATATTTTTCCTCCAATACAGATGCTCCTGATACTTAAAAGGGAAATGTTTCTAAGAAAGGTTTAGGGCTATGGGACATAGGGTTTGGACACTAGAAAGTTTTCATGCAGCCATTGTCTGACCAGCGTCTCCGTGCTAGTTTTATTCTATGGGAGGCAGAAGGGTTAGGTAGGACTTACCATTTAGTTTAATGAAAGCAGAACATAAGGTATAAGGATCTTGCTTACTGTGTCCAAATAACCTGCTCTTCATATTTGCATTCACACACAAGTGGGAGACATGAACTAAACAGGGCACCCTATGAACAATACATTGGTGCCTATTGAAAAGTAATCTGTCTGTGCCACACAGAAACCCCATTACAACCTACAGCGAGACTTCCATTTTGTTATTTTTATCGTGCAAATATAATTTGTCTGTGGCCTCTTCTTCCCTACTGTGAAATCTGGCTCTTCCCAAAGTGGTGTTCGGTTGCTTAAGTAAATCCAAGGGGTAGTTCATTCCTTTTTAGTATATTATAGAATATCCTGTTATCAGCAACTTTTTAATTTTTTTGCCCTCATTTTCAGTTTCTCCATTTTTCAAATGGGGTGTCACTGACCCTG	Refseq >NM_001085692|Xenopus laevis protein inhibitor of activated STAT, 1 (pias1), mRNA GCGCAAAGCAGCAAGATGGCGGACAGTGCGGAACTGAAGCAAATGGTTATGAGTCTTCGAGTATCTGAGCTGCAAGTGCTTTTGGGATACGCTGGGCGCAACAAACACGGTCGTAAACACGAACTGTTGACCAAAGCTCTTCACTTGCTTAAGACTGGGTGCAGCCCCGCTGTGCAAATGAAAATCAAGGAATTGTATCGGAGGCGGTTCCCTTTGAAAATTTTGACTCCTGCTGACTTCACTTTGCCCAGTGTGCACTCAAGCTCTATGCCAGTCAACCTGTCACCATCCTCCATTCCTCAGCTCTCCTATGATGGTCATCCAGCTTCTTCTCCATTACTACCAGTCACTCTCCTCCCCAAACATGAACTGGATCTCCCACACCTCACATCAAATCTCCACCCTGTCCATCCGGATGTCAAACTTCAAAAACTTCCTTTCTATGACCTTCTGGATGAACTTATCAAACCCACAAGTTTAGCATCTGATAACAGTCAGCGCTTTCAAGAAACTTGCTTTGCATTTGCATTAACACCGCAACAAGTACAGCAGATAAGTAGCTCAATGGATATCTCTGGGACAAAATGTGACTTCACAGTACAAGTGCAGCTCAGGTTCTGTCTCTCTGAGACTAGCTGCCCCCAAGAAGATCATTTTCCACCCAACCTGTGTGTAAAGGTGAATGGAAAACCATGTAACCTTCCAGGGTATCTTCCACCAACTAAAAATGGGGTTGAACCAAAGCGACCTAGTCGACCAATCAATATTACCTCACTTGTACGACTTTCCACAACTGTTCCAAACACAATTGTGGTGTCATGGACTGCAGAAATTGCAAGGCATTTTTCTTTGGCTGTTTATCTGGTGAAGCAACTTTCATCGGCCATCTTGCTCCAGAGACTGCGAGCAAAAGGAATCCGCAACCCTGATCATTCCAGGGCACTAATTAAAGAGAAGCTCACAGCTGATCCAGACAGTGAAATTGCCACAACCAGTTTACGTGTCTCCCTCCTGTGTCCGCTTGGCAAGATGCGACTGACCATCCCCTGCAGGTCTCTTACATGCTCACACCTTCAGTGCTTTGATGCCACACTCTACATTCAGATGAATGAGAAGAAGCCCACTTGGGTGTGTCCTGTTTGTGACAAGAAAGCTCCATATGAGCATTTAATCATAGATGGTCTCTTTATGGAGATATTGAAGTGCTGCACAGACTGTGATGAAATACAGTTTAAGGAAGATGGATCCTGGTCACCAATGCGATCAAAGAAGGAAGTACAGGAGGTCACAACATCTTATAATGGAGTAGACAATGGCTGCATCAGCAGCTCAGTTGAGCACCAGGTGCCCTCGAACCATCACTCCTCCAACAAAAACAAGAAGGTGGAAGTAATAGACCTGACGATAGACAGCTCTTCAGATGAGGAGGAAGAAGAACCCTGTCCCAAGAGGAGTTGCCCATCCATTACTCCTGCATCCCCTCTCAGCAATAAAAGTATGTTGAATCTGCAGCACCAGGCTTCTCCGATCTCTCGAACTCCTAGCCTGCCACCTGTTGACTCCACATACATCAATGCACCTTTACTTCAGGACTATCGGCATCCCTTCCACATGGCACACATGCCTTATGACTTACAAGGCTTGGATTTCTTTCCTTTCCTGTCTGGAGAAAACCAGCATTACAACACATCACTGTTGGCGGCGGCTGCTGCTGCAGCATCAGAAGAGCCAGATTTGCTTCATTCTTCCCGTTTCTTCCCCTACACCTCTTCCCAGCTTTTCTTGGACCAGTTAAACGCAAGTGCAAGCTCTTCTTTGCCAGCAACTAATGGGAGTAACAGTGGCAGTAACAGCAGTTTGGTATCGTCGAACAGCCTTCGTGAGTCCCACAATGCCCCCAGCCGTGGGCCAGCAGACAGCTCCTCACTTTATGGCATCATACCAGATGTTATCTCCTTGGACTGATTGACAGATGCAGGACCCCTACCACCTGATTTCTTTATTTTATTATTTTTTTTAAGGGAAATGCTAAAAATACAAAAAAAGCTAAAGACATGTACAGAGAACAGAACTATATTTTCAGTTTTAATTTTGTATATAAACGGAAGACTATACTCATCTGATAAAACTGAAACCTGGCCCCGCCTCTTACTCACTCTCCCCCCTCTCCATTTTTAATTTTTCAACCTAATCCCAGAGATTGACTCTTGTTCTAGAGATTTCTCTGACTTTTTTTTTTGTTTTTATTTTATTTTTTTAAATACTAAAGCTCCCCAGCATTGCTCATCCCACTGCACTCTACAGCAGCCACCATATTGGTATGGCCTGAGCTGCCTCTACCACTTCTAGAAATCCAAACTCAAGGATTGTTAAGTGAAAACCGGCTCATTAAAATCTGCACTTCTTTATGGCAATCCAGGTGAGCTCTGGGGCACCACAGATACTTTGACATTGGCTTCTCCTTTAACCCAACAATGACTGAGTTTGGAGCTCAAAAATACTTCGCTGCCAAATGGACATTTAAGAATAAAGCACTTCAGTCTGCAATCAGCACTAAATAAATGTCAGATTGTATCTGTTAATTTGGCCTGGGCTGAACTAAAAGTGGATTTCATTCATTGGTACCCTGACACAGACACTTGAGTGACAATAAGATGGTTGTCCCCTTCCTGTTTGGTGCCATCTTTCTCCTCTGTCTTTTGCTGTCCAATCTAGGAGAGATTTTAGTTCCAGCTACACCTCCTAAAGTCCTTTCAGCATTTAGCAAGCTAGCAGTTTGGTGCCAATCAAACCTCCCTTTCAGGCATTGTTACTCTTTCTTTGAAAGTTGACAAAATGTCAATGTTATTTAAAACGCCATCATGTCTGTCTAGCTATTTGTGCTTGCTCTGTGCCTCAAGGGAGACATGAACTCACTCCAGTGTGTAATGCTTCTGTGCATCCCTACTGCAATGAAAATAATTATTTATTCACCTCTGAATATGCATTGGATAAACACAGAGTGCAATGACGGCATCATTGCTTTTTAAAAAAAAAATGATCTAGCAGTCCTAATGCCAGTTCTTTTCATTGAAATATTGCATAGGGCCTATTTTCACATGATGTTCATTATTCCCTCACAAGAGAGTAGAGGTATAATTAAAAGACACTTTAAGCAAGATGCATAGTGTGGCCAAAGGGTGTGTTAATCTACGGTAAAGGAGAGGATGTCATCATTATGTCAGGATCTGTAATAGTAACCCCCCCCCTCCCAGAAAAACCTCAGCTTTGCATGTGGGAGTTGGGATTAACTGGGTCAGGGTTAATATATTTCCCCCCTTACAGACATTCCTGAGAATTAAAGGGAAATGTTTCTATGAAAGGTTTAGACCAGTGATCCCCACCCTGTGGCTTGTGAGCAACACGTTCTCCCAGTGGCCTCAAAGAAGATGCTTATTTTTGAATTCCTGGCTTGGAGGCACCTTTGGTTGCATAAAACCATGTGTACTACTAAATTGAGCCTCCTGTAGGCTGTGAGCTGCCAATCACAGACCATATGTGGCACTACCAGGAAATGTTTGCATGCTTGTGTTGCTCTCAAATTTTTTTTACATTTGAAAGTGGCTCACTGGTTCAAATGGTTGGGGACCCCTGGTTTAGACCTATGGCACTTAGGGTTTCATTTGGTTTACACACTGGAAAGTTTCCATGCAGCTATTGTCTGGTCTGTGCCGTTTTATACTACGGAAGAGGGAAGGGTCCATTTTGGGCACTTTTTCTATGGAAAAATTCCAGAAATCTGATCCCCATGTGTATTAGAGACCTTAGGTTCTATTTGGGTGAACTTAGAACATCAGATACAAGGTTATTGTATACTGTGTCCACATACCTGCTCTTCATATGTGCGTGTGCACCTGACCCCATCAGTCCAAAAAGCTCTGTGAGGCTACAATTTGTTTTTACTGCTCAACAAAAGTATCTTTCTATTCAGGCCCTTCCCTATGCATATTCCAGGCTCTCATTCACACCACTGCTTGGTTGCTAGGGTAAATTGCACCCTAGAAACCAGATAGCTACTGTAACACCAAATTGGAGAGCTGCTAATCAAAAACCTAAATAATTTAATAGCCACCTGCAGACTGTCTAATTTTCACTATTTCATACTAAAGTTAATAGGAAGATGAGTACCTTGTTAAGACCTAGCACCAAATAGCAGTTCAATTCAGAGGCTCATAGTTGCAGGACAAATATGCTATGAAAATTAACTCCAAAATAGATTTTAGGGTGGGCACGGACTGAGGATGTGCTGGGACTGTTGTGCTTTTACCAGTCAGAATGAAAAATATCCAAATTATCCATATCCTTGTGCCAGATAGCTCCTGGGTCAGGGTTGTGGGTATCATGGCAGAGAGTGCAGTGGGATGGTTTACATGCTGTCTAGCTCAACTAGAAGGATTGTGCGTGACTTCATTTATTACTTTAAGCTAAGTTTGCCAGTGTTGGGGACAAGGGCGCTGCTTATTCATTAGGCCCATAAGCAGCCGAGTGGGCAGGAGTTGATGTAAATATTACAAATCAGATCTTATTGCTGGTTTCTGTGGACTGAATTTGTAACTCATTGCCTTAACAATGTTTCCATATGGCATGCCAGACCAGCTGAAAGGCTTTTAAACCTGTATAGTAGGCCAATGTCAGTTTGTATAAAGTATCAAGTGAAAATATTTATTACTTGCATTGGACAGAAATTGTTTACCTATTGAATGTTATCTGTTTCTGTAGAAGTCTTTAGATGTAATAAAAAAGCATTCTAATGAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002932990|PREDICTED: e3 SUMO-protein ligase PIAS1-like [Xenopus (Silurana) tropicalis] MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKTGCSPAVQMKIKELYRRRFPLKILTPADFSLPSVHSSSMPVNLSPSSIPQLSYDGHPASSPLMPVSLLPKHELDLPHLASNLHPVHPDVKLQKLPFYDLLDELIKPTSLASDNSQRFQETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNGKPCNLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNFSLAVYLVKQLSSAILLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRSLTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKCCTDCDEIQFKEDGSWSPMRSKKEVQEVTTSYNGVDSGCISSSVEHQVSSNQQSSKNKKVEVIDLTIDSSSDEEEEEPCPKRSCPSITPASPLSNKGMLNLQHQASPISRTPSLPPVDSTYINAPILQDYRHPFHMTHMPYDLQGLDFFPFLSGENQHYNTSLLAAAAAAASEEPDLLHSSRFFPYTSSQLFLDQLNASASSSLPATNGSNSGSNSSLVSSNSLRESHSAPSRGPADSSSLYGIMPDVISLD	Refseq >NP_001079161|protein inhibitor of activated STAT, 1 [Xenopus laevis] MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKTGCSPAVQMKIKELYRRRFPLKILTPADFTLPSVHSSSMPVNLSPSSIPQLSYDGHPASSPLLPVTLLPKHELDLPHLTSNLHPVHPDVKLQKLPFYDLLDELIKPTSLASDNSQRFQETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNGKPCNLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIARHFSLAVYLVKQLSSAILLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRSLTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKCCTDCDEIQFKEDGSWSPMRSKKEVQEVTTSYNGVDNGCISSSVEHQVPSNHHSSNKNKKVEVIDLTIDSSSDEEEEEPCPKRSCPSITPASPLSNKSMLNLQHQASPISRTPSLPPVDSTYINAPLLQDYRHPFHMAHMPYDLQGLDFFPFLSGENQHYNTSLLAAAAAAASEEPDLLHSSRFFPYTSSQLFLDQLNASASSSLPATNGSNSGSNSSLVSSNSLRESHNAPSRGPADSSSLYGIIPDVISLD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.52421
Unigene EST Profile			EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PIAS1
mouse		MGI	Pias1	All(2) Targeted, knock Out(1) Targeted, other(1)
zebrafish			pias1

Publications
First:		GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. [Cell 1998]
Most recent:		Regulation of early Xenopus development by the PIAS genes. [Dev Dyn 2011]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding zinc ion binding
Biological:
Cellular Component:
EC:
KOG:		[K] Zn-finger transcription factor

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		Str.38011.5.S1_at	Xl.19184.1.S1_at
Affymetrix 2.0			Xl2.19184.1.S2_at [+] Xl2.52421.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images