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Summary Expression Gene Literature (521) GO Terms (8) Nucleotides (147) Proteins (42) Interactants (1598) Wiki
XB-GENEPAGE- 486770

Gene Symbol: gsc

Gene Name: goosecoid homeobox

Synonyms: Xgsc , goosecoid , gsc-a , gsc-b
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor

Protein Function :
Plays a central role in executing Spemann's organizer phenomenon (the dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another...[+]


Interactants: Loading ...

Disease Ontology:
  

OMIM Diseases:
   SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, AND SKELETAL ABNOR
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Xenbase Gene ID XB-GENE-486771 XB-GENE-6252605 XB-GENE-864870
Gene Symbol gsc gsc.L gsc.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq NCBI Nucleotide Refseq
Protein Refseq TrEMBL TrEMBL TrEMBL NCBI Protein TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.10803 Xl.801 Xl.797
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 208 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine gsc gsc.L gsc.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards GSC OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Gsc MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR gsc ZFIN Ensembl
chicken
GEISHA GSC Ensembl
fruit fly
FLYBASE Gsc Ensembl
worm
WORMBASE
Publications
First: Molecular nature of Spemann''s organizer: the role of the Xenopus homeobox gene goosecoid. [Cell 1991]
Most recent: Tbx2 is required for the suppression of mesendoderm during early Xenopus development. [Dev Dyn 2018]
View All Papers 106 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 13 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 7 terms 3 terms 4 terms
PANTHER gsc
KEGG Pathways K09324 K09324 K09324
KOG [K] Transcription factor PHOX2/ARIX, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 6 clone(s) EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino gsc MO1 gsc MO1 gsc MO1
ORF gsc.S ORF1
Affymetrix 1.0 Str.10803.1.S1_s_at [+] Xl.797.1.S1_at [+]
Affymetrix 2.0 Xl2.797.1.S1_at [+]

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556