Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (558) GO Terms (8) Nucleotides (148) Proteins (43) Interactants (1821) Wiki
XB-GENEPAGE-486770

Gene Symbol: gsc

Gene Name: goosecoid homeobox

Synonyms: Xgsc , goosecoid , gsc-a , gsc-b ( Add Xenopus synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Plays a central role in executing Spemann's organizer phenomenon (the dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another...[+]

Interactants: Loading ...
Disease Ontology:

OMIM Diseases: SHORT STATURE, AUDITORY CANAL ATRESIA, MANDIBULAR HYPOPLASIA, AND SKELETAL ABNOR

1/6
 
Xenbase Gene ID XB-GENE-486771 XB-GENE-6252605 XB-GENE-864870
Gene Symbol gsc gsc.L gsc.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq NCBI Nucleotide Refseq
Protein Refseq TrEMBL TrEMBL TrEMBL NCBI Protein TrEMBL Swiss-Prot Refseq Swiss-Prot Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine gsc gsc.L gsc.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards GSC OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Gsc MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR gsc ZFIN Ensembl
chicken
GEISHA GSC Ensembl
fruit fly
FLYBASE Gsc Ensembl
worm
WORMBASE
Publications
First Molecular nature of Spemann''s organizer: the role of the Xenopus homeobox gene goosecoid., Cell 1991                
Most Recent Integration of Wnt and FGF signaling in the Xenopus gastrula at TCF and Ets binding sites shows the importance of short range repression in patterning the marginal zone., Development 2019  
All View All Papers 113 paper(s) referencing morpholinos 7 paper(s) referencing OMIMs 14 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 7 terms 3 terms 4 terms
PANTHER gsc
KEGG Pathways K09324 K09324 K09324
KOG [K] Transcription factor PHOX2/ARIX, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 6 clone(s) EXRC - 2 clone(s)  
Dharmacon Dharmacon Dharmacon
Morpholino gsc MO1 gsc MO1 gsc MO1
ORF gsc ORF1 gsc.S ORF1
Affymetrix 1.0 Str.10803.1.S1_s_at [+] Xl.797.1.S1_at [+]
Affymetrix 2.0 Xl2.797.1.S1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.2


Major funding for Xenbase is provided by grant P41 HD064556