gsc Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (301)

Nucleotides (142)

Interactants (512)

XB-GENEPAGE-486770

Gene Symbol: gsc Gene Name: goosecoid homeobox Synonyms: Xgsc, goosecoid Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: t(158) , chrd(107) , wnt8a(60) , otx2(53) , nodal(52) , bmp4(48) , cer1(43) View All	1/6

XB-GENE-486771

XB-GENE-6252605

XB-GENE-864870

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001016704\|Xenopus (Silurana) tropicalis goosecoid homeobox (gsc), mRNA ATGAAGTTTTCAGCCAGGAGAGAGAGAGACAAAGTCGCAGAGTCTCCTGCTTTCTACTCACTACCCAGCAGAGGATTGCCCCCCACTAAACCCAGCGCTAAGGAACCCCCAAACAGGACTTGCTTTCCCTCCTCACACATTTGGGTGATGCCTTCTGGCATGTTCAGCATTGACAACATTTTGGCTGCCAGACCTCGCTGCAAGGAGTCGGTGCTGCTCCCCCAGAATGGCCCGATGGTGTTCTCCAGTCTGGGGGAGTCTCTCTATGGCCCCGCAGATTACAGCGGATTTTATAACCGAGCTGTGGCCCCAACTTCTACTCTTCAAGCGGTGACTGGATCTAGGCTGGGATTCAATAACTACTACTATGGACAGTTGCACGTACAGACGCCTATGGGCCCCTCATGCTGCGGGGCAGTGCAAAGTCTGGGGACGCAGCAATGCTCCTGTGTGCCCCCCGCTACAGCATATGATGGTGCAGGATCAGTGCTGATGCCCCCAGTGCCTCACCAAATGCTCCCTTATATGAATGTGGGCACTTTGTCACGGACTGAGCTACAGTTGCTGAACCAGCTGCACTGCAGGAGGAAGAGGAGGCACAGGACCATCTTCACTGATGAGCAACTGGAAGCACTGGAGAATCTCTTCCAAGAAACCAAGTACCCAGACGTGGGCACCAGAGAACAGCTGGCAAGGAGGGTTCACCTCAGAGAGGAAAAAGTAGAGGTTTGGTTCAAAAATCGAAGAGCAAAGTGGAGGAGGCAGAAAAGATCTTCATCAGAAGAATCAGAAAATACCCAAAAGTGGAATAAGTCCTCAAAAAACTCAACAGAGAAAGGGGACGAACAGGTTAAAAGTGACCTGGACTCTGACAGTTGATTGGTTCCTCTGGAATAAGACTAAAGACTTGCACATCAGGATAGCTGAACGCCCCAGCAGTGCCATGATGTGGGATCTGTACATAAAGTGTAAATATTATCATTTCATTGCCTGTAAATAAAAAAGAATGTGCAGACATTTTGCACAGATACACTGTACTGAATTTACTATTTATACCTTAAGTTAAAGGAATTGCTACAATAAACAGATGGTGAAAAATCAAAAAAAAAAAAAAAAAA	NCBI Nucleotide >M63872\|X.laevis organizer specific homeobox goosecoid mRNA, 3' end AAGTTTTCAGCTGAGAGCGAGAGACGCACACACAAAGTCGCAGAGTATCCTGCTTTCTGTTCTCTACACAGCAGAGGATTGCCCCCCACCAAACCCTGTCCAAGGAGCCCCCCAAAGAGGACTTATTTTTCTCCCCCACACATTTGGGTGATGCCTTCTGGCATGTTCAGCATTGATAACATATTGGCTGCCAGACCTCGCTGCAAGGAGTCGGTATTGCTCCCCCAGAATGGGCCGGTGGTGTTCTCCAGTCTGGGGGAGTCTCTGTATGGCCCCGCAGATTACAGCGGATTTTATAACCGAGCCGTGGCCCCAACATCTACTCTTCAAGGGGTGAATGGATCTAGGCTGGGATTCAATAACTACTACTATGGACAGTTGCACGTACAGACGCACCTGGGCCCCTCGTGCTGTGGGACAGTGCAAGCTTTGGGGACGCAGCAATGCTCGTGTGTACCCCCTGCTACAGCATATGATGGTGCAGGATCAGTGCTGATGCCGCCAGTGCCTCACCAAATGCTCCCTTACATGAACGTTGGCACTTTGTCACGAACTGAGCTGCAGTTGCTTAACCAGCTCCACTGCAGGAGGAAGAGGAGGCACAGGACCATCTTCACCGATGAACAACTGGAAGCACTGGAGAATCTCTTCCAAGAAACCAAGTACCCAGATGTGGGCACCAGGGAACAGCTGGCAAGGAGAGTTCATCTCAGAGAGGAAAAAGTAGAGGTTTGGTTCAAAAATCGAAGAGCAAAGTGGAGGAGGCAGAAAAGATCTTCATCAGAGGAATCAGAAAATGCCCAAAAGTGGAATAAGTCCTCAAAAAACTCAGCAGAAAAAGCGGACGAACAGGTTAAAAGTGACCTGGACTCTGACAGTTGATTGGTTCCTCTGGAATAAGAATAAAGACTTGCACATCAGGATAGCTGAATGCCCCAGCAGTGCCACGATGTGGGATCTGTACATAGAGTGTAAATATTATCATTTCATTGCCTGTAAATAAAAAAATAATGTGCAGACATTTTGCACAGATACACTGTACTGAATTTACTATTTATACCTTAAGTTAAAGGAATTACTACAATAAACAGATGGTGAAAAAT		Refseq >NM_001087809\|Xenopus laevis goosecoid homeobox (gsc-b), mRNA TGAAGTTTTCAGAGACAAAGTCGCAGAGTCTCCTACTTTCTACTCACTACTACACAGCAGAGGATTAACCCCCCCAACTCTGTGCCAAGGATCCCCCAAACAGGACTTGTTTTTTTCTCCCCCACACATTTGGGTGATGCCTTCTGGCATGTTCAGCATTGATAACATTTTGGCTGCCAGACCTCGCTGCAAGGAGTCGCTGCTGCTCCCCCAGAATGGGCCGTTGCTCTTCTCCAGTCTGGGGGAGTCTCTCTATGGCCCCGCAGATTACAGCGGATTTTATAACCGGACTGTGGCCCCAACTTCTGCTCTCCAAGGAGTGAATGGATCTAGGCTGGGATACAATAACTACTACTATGGACAGTTGCATTTACAGACGCCCGTGGGCCCCTCGTGTTGTGGAGCAGTTCAAGCTCTGGGGACGCAGCAGTGCTCGTGTGTACCCTCAGCTACAGCATACGATGGTGCAGGGTCAGTGCTGATTCCACCAGTGCCTCACCAGATGCTCCCTTACATGAATGTTGGCACTTTGTCCAGGACTGAGCTGCAGTTACTTAACCAGCTGCACTGCAGGAGGAAGAGGAGGCACAGGACCATCTTCACCGATGAACAACTGGAAGCACTGGAAAATCTCTTCCAAGAAACCAAGTACCCAGATGTGGGCACCAGAGAACAGCTGGCAAGGAGGGTTCATCTCAGAGAGGAAAAAGTAGAGGTTTGGTTCAAAAATCGAAGAGCAAAATGGAGGAGGCAGAAAAGATCTTCATCAGAAGAATCAGAAAATGCCCAAAAGTGGAATAAATCCTCAAAAAACTCTGCAGAGAAAAGGGACGAGCAGGCTAAAAGTGACCTGGACTCTGACAGTTGATTGGTTCCTCTGGAATAAGACTAAAGACTTGCACATTGGGATAGCTGAATGCCCCAGCAGTACCATGAAGTGGGATCTGTACATAGAGTGTAAATATTATCATTTCATTGCCTGTAAATAAAAAAAGAATGTGCAGACATTTTGCACAGATACACTGTACTGAATTTACTATTTATACCTTAAGTTAAAGGAATTACTACAATAAACAGATGGTGAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001016704\|goosecoid homeobox [Xenopus (Silurana) tropicalis] MPSGMFSIDNILAARPRCKESVLLPQNGPMVFSSLGESLYGPADYSGFYNRAVAPTSTLQAVTGSRLGFNNYYYGQLHVQTPMGPSCCGAVQSLGTQQCSCVPPATAYDGAGSVLMPPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARRVHLREEKVEVWFKNRRAKWRRQKRSSSEESENTQKWNKSSKNSTEKGDEQVKSDLDSDS	NCBI Protein >AAA49744\|homeobox gene; putative [Xenopus laevis] KFSAESERRTHKVAEYPAFCSLHSRGLPPTKPCPRSPPKRTYFSPPHIWVMPSGMFSIDNILAARPRCKESVLLPQNGPVVFSSLGESLYGPADYSGFYNRAVAPTSTLQGVNGSRLGFNNYYYGQLHVQTHLGPSCCGTVQALGTQQCSCVPPATAYDGAGSVLMPPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARRVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAQKWNKSSKNSAEKADEQVKSDLDSDS UniProtKB		Refseq >NP_001081278\|homeobox protein goosecoid isoform B [Xenopus laevis] MPSGMFSIDNILAARPRCKESLLLPQNGPLLFSSLGESLYGPADYSGFYNRTVAPTSALQGVNGSRLGYNNYYYGQLHLQTPVGPSCCGAVQALGTQQCSCVPSATAYDGAGSVLIPPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARRVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAQKWNKSSKNSAEKRDEQAKSDLDSDS UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.10803	Xl.801		Xl.797
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		129 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	GSC
mouse		MGI	Gsc	All(4) Targeted, knock Out(2) Targeted, other(1)
zebrafish		ZFIN	gsc	2 Lines(s)

Publications
First:		Molecular nature of Spemann''s organizer: the role of the Xenopus homeobox gene goosecoid. [Cell 1991]
Most recent:		The XenopusTGFBI is required for embryogenesis throughregulation of canonical Wnt signalling. [Dev Biol 2013]
		View All Papers 62 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor PHOX2/ARIX, contains HOX domain

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 6 clone(s)	EXRC - 2 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.10803.1.S1_s_at [+] Str.10803.1.S1_at			Xl.797.1.S1_at [+] Xl.801.1.S1_at Xl.801.1.A1_at Xl.801.1.S1_s_at
Affymetrix 2.0					Xl2.797.1.S1_at [+] Xl2.801.1.A1_at

Symbol legend[+]