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Summary Expression Gene Literature (52) GO Terms (29) Nucleotides (158) Proteins (34) Interactants (793) Wiki
XB-GENEPAGE-486816
Gene Symbol: irx1

Gene Name: iroquois homeobox 1

Synonyms: Xiro , Xiro1 , irx1-a , irx1-b , iro ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural...[+]

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
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Xenbase Gene ID XB-GENE-486817 XB-GENE-865648 XB-GENE-6254076
Gene Symbol irx1 irx1.L irx1.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100038208
397976
735237
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine irx1 irx1.L irx1.S
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards IRX1 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Irx1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR irx1a irx1b ZFIN Ensembl
chicken
GEISHA IRX1 Ensembl
fruit fly
worm
WORMBASE
Publications
First Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate., EMBO J 1998  
Most Recent Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development., Dis Model Mech 2020                    
All View All Papers 7 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 27 terms 23 terms 20 terms
PANTHER irx1
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks irx1
Morpholinos irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2
ORFs irx1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.13.0


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