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Summary Expression Gene Literature (50) GO Terms (29) Nucleotides (158) Proteins (34) Interactants (787) Wiki
XB-GENEPAGE-486816
Gene Symbol: irx1

Gene Name: iroquois homeobox 1

Synonyms: Xiro , Xiro1 , irx1-a , irx1-b , iro ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural...[+]


Interactants: Loading ...
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Xenbase Gene ID XB-GENE-486817 XB-GENE-865648 XB-GENE-6254076
Gene Symbol irx1 irx1.L irx1.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene: 100038208
Entrez Gene: 397976
Entrez Gene: 735237
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine irx1 irx1.L irx1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards IRX1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Irx1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR irx1a irx1b ZFIN Ensembl
chicken
GEISHA IRX1 Ensembl
fruit fly
worm
WORMBASE
Publications
First Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate., EMBO J 1998  
Most Recent Six1 and Irx1 have reciprocal interactions during cranial placode and otic vesicle formation., Dev Biol 2019  
All View All Papers 7 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 27 terms 23 terms 20 terms
PANTHER irx1
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Horizon Horizon Horizon
Morpholino irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2
ORF irx1.S ORF1
Affymetrix 1.0 Str.31298.1.S1_at Xl.69.1.S1_at
Affymetrix 2.0 Xl2.69.1.S1_at Xl2.47737.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.12.2


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