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Summary Expression Gene Literature (82) GO Terms (52) Nucleotides (58) Proteins (34) Interactants (849) Wiki
Gene Symbol: tbx5

Gene Name: T-box 5

Synonyms: xtbx5 , tbx-5 , xtbx-5 , tbx5-a , tbx5-b ( Add synonyms , Nomenclature history )

Gene Function: T-box transcription factor

Protein Function :
DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:10079235). May bind to the core DNA motif of promoters.

Interactants: Loading ...
Diseases:  Disease Ontology: Holt-Oram syndrome


External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-486855 XB-GENE-865653 XB-GENE-6253071
Gene Symbol tbx5 tbx5.L tbx5.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 619589
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq TrEMBL TrEMBL TrEMBL RefSeq Swiss-Prot TrEMBL NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine tbx5 tbx5.L tbx5.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards TBX5 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Tbx5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ZFIN, AGR tbx5a tbx5b ZFIN Ensembl
fruit fly
First Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19., Genomics 1999  
Most Recent The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis., Dev Biol 2019                                    
All View All Papers 17 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 52 terms 22 terms 4 terms
KEGG Pathways K04695 K10179 K10179
KOG [K] TBX2 and related T-box transcription factors
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks tbx5
Mutants Xtr.tbx5emHorb
Morpholinos tbx5 MO1 , tbx5 MO2 tbx5 MO1 , tbx5 MO2 tbx5 MO1 , tbx5 MO2
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.13.0

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