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Summary Expression Gene Literature (518) GO Terms (53) Nucleotides (88) Proteins (46) Interactants (865) Wiki
XB-GENEPAGE-486854
Gene Symbol:
tbx5

Gene Name:
T-box 5

Synonyms:
xtbx5 , tbx-5 , xtbx-5 , tbx5-a , tbx5-b ( Add synonyms , Nomenclature history )

Gene Function:
T-box transcription factor

Protein Function :
DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:10079235). May bind to the core DNA motif of promoters.


InterPro :
HCO3 transpt euk , HCO3 transpt C , PTrfase/Anion transptr , Band3 cytoplasmic dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Holt-Oram syndrome

OMIM:
HOLT-ORAM SYNDROME; HOS

External Links:
1/7
 
Xenbase Gene ID XB-GENE-486855 XB-GENE-865653 XB-GENE-6253071
Gene Symbol tbx5 tbx5.L tbx5.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 619589
373738
373556
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tbx5 tbx5.L tbx5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TBX5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tbx5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tbx5 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR tbx5a tbx5b ZFIN Ensembl
chicken
GEISHA TBX5 Ensembl
fruit fly
worm
Publications
First Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19., Genomics 1999  
Most Recent RA Signaling in Limb Development and Regeneration in Different Species., Subcell Biochem 2020  
All View All Papers 17 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 53 terms 22 terms 4 terms
PANTHER tbx5
KEGG Pathways K04695 K10179 K10179
KOG [K] TBX2 and related T-box transcription factors
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tbx5
Mutants Xtr.tbx5emHorb
Morpholinos tbx5 MO1 , tbx5 MO2 tbx5 MO1 , tbx5 MO2 tbx5 MO1 , tbx5 MO2
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list