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Summary Expression Gene Literature (19) GO Terms (18) Nucleotides (267) Proteins (33) Interactants (374) Wiki
Gene Symbol:

Gene Name:
frizzled class receptor 2

mgc89887 , Fz-2 , Xfz2 , frizzled-2 , frizzled2 , fz2 ( Add synonyms , Nomenclature history )

Gene Function:
transmembrane receptor in the wnt signaling pathway

Protein Function :
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nucl...[+]

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External Links:
Xenbase Gene ID XB-GENE-487022 XB-GENE-17339021 XB-GENE-865666
Gene Symbol fzd2 fzd2.L fzd2.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 493345
mRNA RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fzd2 fzd2.L fzd2.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu059i07      
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards FZD2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Fzd2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Fzd2 Ensembl
ZFIN, AGR fzd2 ZFIN Ensembl
fruit fly
First Xenopus frizzled-2 is expressed highly in the developing eye, otic vesicle and somites., Mech Dev 1999        
Most Recent eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., J Biol Chem 2020            
All View All Papers 5 paper(s) referencing morpholinos 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 0 term 5 terms
KEGG Pathways K02235 K02235
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fzd2
Antibodies Fzd2 Ab1 Fzd2 Ab1
Morpholinos fzd2 MO1 , fzd2 MO2 , fzd2 MO3 fzd2 MO1 , fzd2 MO2 , fzd2 MO3 fzd2 MO1 , fzd2 MO2 , fzd2 MO3
ORFs fzd2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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