Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (19) GO Terms (5) Nucleotides (253) Proteins (26) Interactants (320) Wiki
XB-GENEPAGE- 487021

Gene Symbol: fzd2

Gene Name: frizzled class receptor 2

Synonyms: mgc89887 , Fz-2 , Xfz2 , frizzled-2 , frizzled2 , fz2
Add Xenopus synonyms , Nomenclature history


Gene Function: transmembrane receptor in the wnt signaling pathway

Protein Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nucl...[+]


Interactants: Loading ...

OMIM Disease Associations:
1/6
 
Xenbase Gene ID XB-GENE-487022 XB-GENE-17339021 XB-GENE-865666
Gene Symbol fzd2 fzd2.L fzd2.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.2004 [+] Xl.560 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 44 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine fzd2 fzd2.L fzd2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tneu059i07      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards FZD2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Fzd2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN fzd2 ZFIN Ensembl
chicken
GEISHA FZD2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Fritz: a secreted frizzled-related protein that inhibits Wnt activity. [Mech Dev 1997]
Most recent: Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling. [Exp Eye Res 2016]
View All Papers 5 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 4 terms 0 term 5 terms
EC
PANTHER fzd2
KEGG Pathways K02235 K02235
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Fzd2 Ab1 Fzd2 Ab1
Morpholino fzd2 MO1 , fzd2 MO2 , fzd2 MO3 fzd2 MO1 , fzd2 MO2 , fzd2 MO3 fzd2 MO1 , fzd2 MO2 , fzd2 MO3
ORF fzd2 ORF1
Affymetrix 1.0 Str.2004.1.S1_at [+] Xl.560.1.S1_at [+]
Affymetrix 2.0 Xl2.560.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556