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Summary Expression Gene Literature (633) GO Terms (20) Nucleotides (43) Proteins (23) Interactants (1498) Wiki
XB-GENEPAGE- 487168

Gene Symbol: nodal1

Gene Name: nodal homolog 1

Synonyms: nr1 , Xnr-1 , Xnr1 , nodal-related 1 , nr1-a , spaw , nodal
Add Xenopus synonyms , Nomenclature history


Gene Function: transforming growth factor beta and bone morphogenetic protein related protein

Protein Function:
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activa...[+]


Interactants: Loading ...

OMIM Disease Associations:
1/6
 
Xenbase Gene ID XB-GENE-487169 XB-GENE-865681 XB-GENE-17337560
Gene Symbol nodal1 nodal1.L nodal1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.26907 Xl.1037
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 41 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine nodal1 nodal1.L nodal1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tgas124h10      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM, MalaCards, KEGG Disease, DECIPHER Protein Atlas, Allen Brain Atlas
mouse
MGI, IMPC Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN spaw ZFIN Ensembl
chicken
GEISHA NODAL Ensembl
fruit fly
worm
WORMBASE
Publications
First: Effects of ionic concentration on permeability properties of nodal membrane in myelinated nerve fibres of Xenopus laevis. Potential clamp experiments. [Acta Physiol Scand 1973]
Most recent: HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner. [Biol Open 2017]
View All Papers 105 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 12 terms 0 term
EC
PANTHER nodal1
KEGG Pathways K04666 K04666
KOG [T] Transforming growth factor beta, bone morphogenetic protein and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino nodal1 MO1 , nodal1 MO2 , nodal1 MO3 , nodal1 MO4 , nodal1 MO5 , nodal1 MO6 , nodal1 MO7 , nodal1 MO8 nodal1 MO1 , nodal1 MO2 , nodal1 MO3 , nodal1 MO4 , nodal1 MO5 , nodal1 MO6 , nodal1 MO7 , nodal1 MO8 nodal1 MO1 , nodal1 MO2 , nodal1 MO3 , nodal1 MO4 , nodal1 MO5 , nodal1 MO6 , nodal1 MO7 , nodal1 MO8
Affymetrix 1.0 Str.26907.1.S1_at Xl.1037.1.S1_at
Affymetrix 2.0 Xl2.1037.1.S1_at

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