Gene Symbol: nodal2 [provisional] Gene Name: nodal homolog 2 [provisional] Synonyms: Xnr-2, Xnr2, nr2 Add Xenopus synonyms Gene Function: transforming growth factor beta and bone morphogenetic protein related protein Interactants: nodal1(98) , grin1(76) , grin2a(59) , grin2b(49) , grin2c(33) , nodal(31) , t(23) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932721|PREDICTED: Xenopus (Silurana) tropicalis nodal homolog 2-A-like (LOC100491883), mRNA ATGGCAGCCCTAGGAGCCCTCTTTTTATTTGCCATGGCCTCCCTTGTGCACGGGAAGCCCATTCATTCAGACAGAAAAGGAGCTAAAATCCCTCTGGCAGGATCTAACCTGGGATACAAGAAATCCAGCAATTCATATGGTTCCAGACTGTCGCAGGGTATGAGATACCCCCCTTCCATGATGCAGTTATACCAGACTCTGATTTTGGGGAATGATACGGATCTGTCAATCCTGGAATATCCCATCCTGCAGGAATCTGATGCCGTTCTAAGCCTCATTGCAAAAAGTTGCGATGTAGTGGGCAATCGATGGACATTGTCCTTTGACATGTCTTCTATATCGAGCAGCAATGAGCTGAAATTGGCCGAGTTGAGGATCCGCCTCCCTTCCTTTGAAAGGTCCCAGGATGTTACCGTAGAGATTTATCACACCAAGGATGGTCAGGAGAATCTTTTCATGGGATCCTTTAAGACTAACCCTTCTGTTGCAATGGGTTCCTCGTGGAAGGTTTTTAATCTAACTAAGATGCTCCAGTATTATCTCCACCACGGGGAGCCATTCACAAATGATGAATACATAGAAGTTAAGAACCTGCACGAGAGAGTCAGGCCACGTGTCATTAAGAGAGGAGCAAGGACTGAGGCAGAGGAAGGCCTTCAGAGGAATAAAGACAATACCCCTGTGTCCAGTTTTCCCACAGACAAAGTTGTGCTGGTAGTGTTCACCAGGGACAAGCCCACTGCTAATTATTTTGGCTCTCCCAGTCTCATCCACACCGTGGAGTCCTCCAAGTATGTTATGAGTGAAAGCACAGTCAGGGTGGCAGATACCAGGAGACACCGGCGCAACCAAAAAACAAAAAACTCCATAGTCATGAACACCATGCCCTCTAGATACGTTGGAAAAACCCTTTGCAGGAGAGTGGATATGATAGTGGATTTTGAAAAGATTGAATGGGGCGATCGGATTGTCTATCCCAAAAGATTCAACGCCTATAGGTGCGAGGGGGCCTGCCCCATTCCTCTGAATGAAACCTTCAAGCCAACGAACCATGCCTACATCAAGAGTCTGGTCAAGCTGTATGATGAAGAGAAAGTTGAATGTTCCTCGTGTATCCCTGTAAAGATGAGCCCACTGTCCATGTTACTGTACGAAGACGGAGAAGTTGTACTGAAGCATCACGAGGACATGATAGTGGATGAGTGTGGCTGCAACTGAACTTAGTGACACGGATATGTGCATGGCTGTTCCTTTATATCTGCCATACCCTGCATCGTGGCCATGCTGTGTTCCCTGTATAGAGTGTACATAGAACAAAAGTCTATTTTTATATAAAGCACATGAAAAAGTATTTATTCTATTAAGAGTTATATATTGTCTGAGCACTACAATAAAATATTAAACT	Refseq >NM_001087967|Xenopus laevis nodal homolog 2 (nodal2), mRNA CTGCTTTGGAAGAGTCAGACAATCAATACAGATACCTCTCTCCAGAGATGGCAAGCCTAGGAGTCATCTTGTTCTTCGTCATTGCTTCCCTTATCCACGGGAAACCCATTCATTCAGAGAGAAAAGCAGCTAAGATCCCTCTTGAAGGCTCTAACCTGGGATACAAGAAACCCAACAATATATATGGCTCCAGACTGTCCCAGGGTATGAGATACCCCCCTTCCATGATGCAGTTATACCAGACCCTGATTTTGGGAAATGATACAGACCTGTCAATCCTGGAATATCCTGTCCTGCAAGAATCTGATGCCGTTCTAAGCCTCATTGCAAAAAGTTGTGTTGTAGTGGGCAATCGATGGACATTATCTTTTGACATGTCTTCTATATCCAGCAGCAATGAGCTGAAATTGGCTGAGCTGAGAATCCGCCTCCCTTCATTTGAAAGATCTCAGGATGTTACTGTAGAGATCTACCACACCAAGGAAGGTCAGGAAAATCTCTTTATGGGATCCTTTAAGACAAACCCTTCTGTTGCAATGGGTTCCTCGTGGAAGATCTTTAACCTAACTAGGATGCTCCAGTATTATCTCCATCAAGGGGAGCCATTCACCAACGTTGAATACATAGAAGTTAAGAACATGCATGAGAGAGCCAAGCCACATGTCATTAAGAGAGGAGTAAGGGCTGAGGTTGAAGAAGGTCTACAAAGGAATAAAGACAATACCCCTGCATCCAGTTTTCCTACAGAGAGAGTTGTCCTGGTTGTGTTCACCAGGGACAAGCCCACTGCTAGTCATTTTGGATCTCCTAGTCTCATCCACACTGTGGAGTCTTCCAAGTATGTCATGAGTGAAAACACAGTCAGGGTGACAGATACCAGAAGACCCCGGCGCAACCAAAAAACGAAAAATACCATTGTCATGAACACCATCCCTTCCAGAAGCGTTGGGAAAACCCTTTGCAGGAGAGTGGATATGATAGTGGATTTTGAAAAGATTGAATGGGGTGATCGGATTGTCTATCCCAAAAGATTCAATGCCTATAGGTGTGAGGGAGCCTGTCCTATTCCTTTAAATGAAACCTTCAAGCCAACGAACCATGCCTACATCAAGAGTCTGGTCAAGTTGTACGATCAAGAGAAAGTGGAATGTTCCTCCTGTGTCCCTGTAAAGATGAGCCCACTGTCCATGTTACTGTATGAAGACGGAGAAGTTGTACTGAAGCATCACGAGGATATGATTGTGGATGAGTGTGGATGTAACTGAATTAATTGAGATATACGTGCATGGGCGTTTCTTTATATAAATATATGCCATAAACTGTTTTGTGGCATGTCGCATTCCTTGTATATAGTGTAGATATTATAAAAAAGTTTTTTTTATATAATGTGCAAGAAAAAAATATTTATTCTATTGAGTTATATATTGTCTGAGCACTCTACAATAAAATATTGAATTCA
Protein		NCBI Protein >XP_002932767|PREDICTED: nodal homolog 2-A-like [Xenopus (Silurana) tropicalis] MAALGALFLFAMASLVHGKPIHSDRKGAKIPLAGSNLGYKKSSNSYGSRLSQGMRYPPSMMQLYQTLILGNDTDLSILEYPILQESDAVLSLIAKSCDVVGNRWTLSFDMSSISSSNELKLAELRIRLPSFERSQDVTVEIYHTKDGQENLFMGSFKTNPSVAMGSSWKVFNLTKMLQYYLHHGEPFTNDEYIEVKNLHERVRPRVIKRGARTEAEEGLQRNKDNTPVSSFPTDKVVLVVFTRDKPTANYFGSPSLIHTVESSKYVMSESTVRVADTRRHRRNQKTKNSIVMNTMPSRYVGKTLCRRVDMIVDFEKIEWGDRIVYPKRFNAYRCEGACPIPLNETFKPTNHAYIKSLVKLYDEEKVECSSCIPVKMSPLSMLLYEDGEVVLKHHEDMIVDECGCN	Refseq >NP_001081436|nodal homolog 2-A precursor [Xenopus laevis] MASLGVILFFVIASLIHGKPIHSERKAAKIPLEGSNLGYKKPNNIYGSRLSQGMRYPPSMMQLYQTLILGNDTDLSILEYPVLQESDAVLSLIAKSCVVVGNRWTLSFDMSSISSSNELKLAELRIRLPSFERSQDVTVEIYHTKEGQENLFMGSFKTNPSVAMGSSWKIFNLTRMLQYYLHQGEPFTNVEYIEVKNMHERAKPHVIKRGVRAEVEEGLQRNKDNTPASSFPTERVVLVVFTRDKPTASHFGSPSLIHTVESSKYVMSENTVRVTDTRRPRRNQKTKNTIVMNTIPSRSVGKTLCRRVDMIVDFEKIEWGDRIVYPKRFNAYRCEGACPIPLNETFKPTNHAYIKSLVKLYDQEKVECSSCVPVKMSPLSMLLYEDGEVVLKHHEDMIVDECGCN UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.36384	Xl.1038
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		10 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human
mouse
zebrafish

Publications
First:		Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. [Science 1992]
Most recent:		Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. [Development 2012]
		View All Papers 11 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity
Biological:
Cellular Component:
EC:
KOG:		[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.36384.1.S1_at [+] StrEns.1229.1.S1_s_at	Xl.1038.1.S1_at
Affymetrix 2.0			Xl2.1038.1.S1_at

Symbol legend[+]

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